Cortical and Subcortical Correlates of Electroencephalographic Alpha Rhythm Modulation

Cortical and Subcortical Correlates of Electroencephalographic Alpha Rhythm Modulation. Feige, B., Scheffler, K., Esposito, F., Salle, Di, F., Hennig, J., & Seifritz, E. Journal of Neurophysiology, 93(5):2864--2872, May, 2005. PMID: 15601739

Paper doi abstract bibtex

Neural correlates of electroencephalographic (EEG) alpha rhythm are poorly understood. Here, we related EEG alpha rhythm in awake humans to blood-oxygen-level-dependent (BOLD) signal change determined by functional magnetic resonance imaging (fMRI). Topographical EEG was recorded simultaneously with fMRI during an open versus closed eyes and an auditory stimulation versus silence condition. EEG was separated into spatial components of maximal temporal independence using independent component analysis. Alpha component amplitudes and stimulus conditions served as general linear model regressors of the fMRI signal time course. In both paradigms, EEG alpha component amplitudes were associated with BOLD signal decreases in occipital areas, but not in thalamus, when a standard BOLD response curve (maximum effect at ∼6 s) was assumed. The part of the alpha regressor independent of the protocol condition, however, revealed significant positive thalamic and mesencephalic correlations with a mean time delay of ∼2.5 s between EEG and BOLD signals. The inverse relationship between EEG alpha amplitude and BOLD signals in primary and secondary visual areas suggests that widespread thalamocortical synchronization is associated with decreased brain metabolism. While the temporal relationship of this association is consistent with metabolic changes occurring simultaneously with changes in the alpha rhythm, sites in the medial thalamus and in the anterior midbrain were found to correlate with short time lag. Assuming a canonical hemodynamic response function, this finding is indicative of activity preceding the actual EEG change by some seconds.

@article{ feige_cortical_2005,
  title = {Cortical and Subcortical Correlates of Electroencephalographic Alpha Rhythm Modulation},
  volume = {93},
  issn = {0022-3077, 1522-1598},
  url = {http://jn.physiology.org/content/93/5/2864},
  doi = {10.1152/jn.00721.2004},
  abstract = {Neural correlates of electroencephalographic ({EEG)} alpha rhythm are poorly understood. Here, we related {EEG} alpha rhythm in awake humans to blood-oxygen-level-dependent ({BOLD)} signal change determined by functional magnetic resonance imaging ({fMRI).} Topographical {EEG} was recorded simultaneously with {fMRI} during an open versus closed eyes and an auditory stimulation versus silence condition. {EEG} was separated into spatial components of maximal temporal independence using independent component analysis. Alpha component amplitudes and stimulus conditions served as general linear model regressors of the {fMRI} signal time course. In both paradigms, {EEG} alpha component amplitudes were associated with {BOLD} signal decreases in occipital areas, but not in thalamus, when a standard {BOLD} response curve (maximum effect at ∼6 s) was assumed. The part of the alpha regressor independent of the protocol condition, however, revealed significant positive thalamic and mesencephalic correlations with a mean time delay of ∼2.5 s between {EEG} and {BOLD} signals. The inverse relationship between {EEG} alpha amplitude and {BOLD} signals in primary and secondary visual areas suggests that widespread thalamocortical synchronization is associated with decreased brain metabolism. While the temporal relationship of this association is consistent with metabolic changes occurring simultaneously with changes in the alpha rhythm, sites in the medial thalamus and in the anterior midbrain were found to correlate with short time lag. Assuming a canonical hemodynamic response function, this finding is indicative of activity preceding the actual {EEG} change by some seconds.},
  language = {en},
  number = {5},
  urldate = {2013-05-21},
  journal = {Journal of Neurophysiology},
  author = {Feige, Bernd and Scheffler, Klaus and Esposito, Fabrizio and Salle, Francesco Di and Hennig, Jürgen and Seifritz, Erich},
  month = {May},
  year = {2005},
  note = {{PMID:} 15601739},
  pages = {2864--2872}
}

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Here, we related {EEG} alpha rhythm in awake humans to blood-oxygen-level-dependent ({BOLD)} signal change determined by functional magnetic resonance imaging ({fMRI).} Topographical {EEG} was recorded simultaneously with {fMRI} during an open versus closed eyes and an auditory stimulation versus silence condition. {EEG} was separated into spatial components of maximal temporal independence using independent component analysis. Alpha component amplitudes and stimulus conditions served as general linear model regressors of the {fMRI} signal time course. In both paradigms, {EEG} alpha component amplitudes were associated with {BOLD} signal decreases in occipital areas, but not in thalamus, when a standard {BOLD} response curve (maximum effect at ∼6 s) was assumed. The part of the alpha regressor independent of the protocol condition, however, revealed significant positive thalamic and mesencephalic correlations with a mean time delay of ∼2.5 s between {EEG} and {BOLD} signals. The inverse relationship between {EEG} alpha amplitude and {BOLD} signals in primary and secondary visual areas suggests that widespread thalamocortical synchronization is associated with decreased brain metabolism. While the temporal relationship of this association is consistent with metabolic changes occurring simultaneously with changes in the alpha rhythm, sites in the medial thalamus and in the anterior midbrain were found to correlate with short time lag. Assuming a canonical hemodynamic response function, this finding is indicative of activity preceding the actual {EEG} change by some seconds.},\n language = {en},\n number = {5},\n urldate = {2013-05-21},\n journal = {Journal of Neurophysiology},\n author = {Feige, Bernd and Scheffler, Klaus and Esposito, Fabrizio and Salle, Francesco Di and Hennig, Jürgen and Seifritz, Erich},\n month = {May},\n year = {2005},\n note = {{PMID:} 15601739},\n pages = {2864--2872}\n}</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" id=\"abstract_feige_cortical_2005\"\n style=\"display:none\">\n Neural correlates of electroencephalographic (EEG) alpha rhythm are poorly understood. Here, we related EEG alpha rhythm in awake humans to blood-oxygen-level-dependent (BOLD) signal change determined by functional magnetic resonance imaging (fMRI). Topographical EEG was recorded simultaneously with fMRI during an open versus closed eyes and an auditory stimulation versus silence condition. EEG was separated into spatial components of maximal temporal independence using independent component analysis. Alpha component amplitudes and stimulus conditions served as general linear model regressors of the fMRI signal time course. In both paradigms, EEG alpha component amplitudes were associated with BOLD signal decreases in occipital areas, but not in thalamus, when a standard BOLD response curve (maximum effect at ∼6 s) was assumed. The part of the alpha regressor independent of the protocol condition, however, revealed significant positive thalamic and mesencephalic correlations with a mean time delay of ∼2.5 s between EEG and BOLD signals. The inverse relationship between EEG alpha amplitude and BOLD signals in primary and secondary visual areas suggests that widespread thalamocortical synchronization is associated with decreased brain metabolism. While the temporal relationship of this association is consistent with metabolic changes occurring simultaneously with changes in the alpha rhythm, sites in the medial thalamus and in the anterior midbrain were found to correlate with short time lag. Assuming a canonical hemodynamic response function, this finding is indicative of activity preceding the actual EEG change by some seconds.\n</div>\n\n\n</div>\n","downloads":0,"bibbaseid":"feige-scheffler-esposito-salle-di-hennig-seifritz-corticalandsubcorticalcorrelatesofelectroencephalographicalpharhythmmodulation-2005","urls":{"Paper":"http://jn.physiology.org/content/93/5/2864"},"role":"author","year":"2005","volume":"93","urldate":"2013-05-21","url":"http://jn.physiology.org/content/93/5/2864","type":"article","title":"Cortical and Subcortical Correlates of Electroencephalographic Alpha Rhythm Modulation","pages":"2864--2872","number":"5","note":"PMID: 15601739","month":"May","language":"en","key":"feige_cortical_2005","journal":"Journal of Neurophysiology","issn":"0022-3077, 1522-1598","id":"feige_cortical_2005","doi":"10.1152/jn.00721.2004","bibtype":"article","bibtex":"@article{ feige_cortical_2005,\n title = {Cortical and Subcortical Correlates of Electroencephalographic Alpha Rhythm Modulation},\n volume = {93},\n issn = {0022-3077, 1522-1598},\n url = {http://jn.physiology.org/content/93/5/2864},\n doi = {10.1152/jn.00721.2004},\n abstract = {Neural correlates of electroencephalographic ({EEG)} alpha rhythm are poorly understood. Here, we related {EEG} alpha rhythm in awake humans to blood-oxygen-level-dependent ({BOLD)} signal change determined by functional magnetic resonance imaging ({fMRI).} Topographical {EEG} was recorded simultaneously with {fMRI} during an open versus closed eyes and an auditory stimulation versus silence condition. {EEG} was separated into spatial components of maximal temporal independence using independent component analysis. Alpha component amplitudes and stimulus conditions served as general linear model regressors of the {fMRI} signal time course. In both paradigms, {EEG} alpha component amplitudes were associated with {BOLD} signal decreases in occipital areas, but not in thalamus, when a standard {BOLD} response curve (maximum effect at ∼6 s) was assumed. The part of the alpha regressor independent of the protocol condition, however, revealed significant positive thalamic and mesencephalic correlations with a mean time delay of ∼2.5 s between {EEG} and {BOLD} signals. The inverse relationship between {EEG} alpha amplitude and {BOLD} signals in primary and secondary visual areas suggests that widespread thalamocortical synchronization is associated with decreased brain metabolism. While the temporal relationship of this association is consistent with metabolic changes occurring simultaneously with changes in the alpha rhythm, sites in the medial thalamus and in the anterior midbrain were found to correlate with short time lag. Assuming a canonical hemodynamic response function, this finding is indicative of activity preceding the actual {EEG} change by some seconds.},\n language = {en},\n number = {5},\n urldate = {2013-05-21},\n journal = {Journal of Neurophysiology},\n author = {Feige, Bernd and Scheffler, Klaus and Esposito, Fabrizio and Salle, Francesco Di and Hennig, Jürgen and Seifritz, Erich},\n month = {May},\n year = {2005},\n note = {{PMID:} 15601739},\n pages = {2864--2872}\n}","author_short":["Feige, B.","Scheffler, K.","Esposito, F.","Salle","Di, F.","Hennig, J.","Seifritz, E."],"author":["Feige, Bernd","Scheffler, Klaus","Esposito, Fabrizio","Salle","Di, Francesco","Hennig, Jürgen","Seifritz, Erich"],"abstract":"Neural correlates of electroencephalographic (EEG) alpha rhythm are poorly understood. Here, we related EEG alpha rhythm in awake humans to blood-oxygen-level-dependent (BOLD) signal change determined by functional magnetic resonance imaging (fMRI). Topographical EEG was recorded simultaneously with fMRI during an open versus closed eyes and an auditory stimulation versus silence condition. EEG was separated into spatial components of maximal temporal independence using independent component analysis. Alpha component amplitudes and stimulus conditions served as general linear model regressors of the fMRI signal time course. In both paradigms, EEG alpha component amplitudes were associated with BOLD signal decreases in occipital areas, but not in thalamus, when a standard BOLD response curve (maximum effect at ∼6 s) was assumed. The part of the alpha regressor independent of the protocol condition, however, revealed significant positive thalamic and mesencephalic correlations with a mean time delay of ∼2.5 s between EEG and BOLD signals. The inverse relationship between EEG alpha amplitude and BOLD signals in primary and secondary visual areas suggests that widespread thalamocortical synchronization is associated with decreased brain metabolism. While the temporal relationship of this association is consistent with metabolic changes occurring simultaneously with changes in the alpha rhythm, sites in the medial thalamus and in the anterior midbrain were found to correlate with short time lag. Assuming a canonical hemodynamic response function, this finding is indicative of activity preceding the actual EEG change by some seconds."},"bibtype":"article","biburl":"http://bibbase.org/zotero/nbusch","downloads":0,"search_terms":["cortical","subcortical","correlates","electroencephalographic","alpha","rhythm","modulation","feige","scheffler","esposito","salle","di","hennig","seifritz"],"title":"Cortical and Subcortical Correlates of Electroencephalographic Alpha Rhythm Modulation","year":2005,"dataSources":["9Wz8i3YBFkeJte2aR"]}