Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study. Fendler, A., Au, L., Shepherd, S. T C, Byrne, F., Cerrone, M., Boos, L. A., Rzeniewicz, K., Gordon, W., Shum, B., Gerard, C. L, Ward, B., Xie, W., Schmitt, A. M, Joharatnam-Hogan, N., Cornish, G. H, Pule, M., Mekkaoui, L., Ng, K. W, Carlyle, E., Edmonds, K., Rosario, L. D., Sarker, S., Lingard, K., Mangwende, M., Holt, L., Ahmod, H., Stone, R., Gomes, C., Flynn, H. R., Agua-Doce, A., Hobson, P., Caidan, S., Howell, M., Wu, M., Goldstone, R., Crawford, M., Cubitt, L., Patel, H., Gavrielides, M., Nye, E., Snijders, A. P, MacRae, J. I, Nicod, J., Gronthoud, F., Shea, R. L, Messiou, C., Cunningham, D., Chau, I., Starling, N., Turner, N., Welsh, L., van As, N., Jones, R. L, Droney, J., Banerjee, S., Tatham, K. C, Jhanji, S., O'Brien, M., Curtis, O., Harrington, K., Bhide, S., Bazin, J., Robinson, A., Stephenson, C., Slattery, T., Khan, Y., Tippu, Z., Leslie, I., Gennatas, S., Okines, A., Reid, A., Young, K., Furness, A. J S, Pickering, L., Gandhi, S., Gamblin, S., Swanton, C., Nicholson, E., Kumar, S., Yousaf, N., Wilkinson, K. A, Swerdlow, A., Harvey, R., Kassiotis, G., Larkin, J., Wilkinson, R. J, & Turajlic, S. Nature Cancer, 2:1321–1337, Nature Publishing Group, oct, 2021.
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study [link]Paper  doi  abstract   bibtex   
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2 positive, 94 were symptomatic and 2 died of COVID-19. In this cohort, 83% patients had S1-reactive antibodies and 82% had neutralizing antibodies against wild type SARS-CoV-2, whereas neutralizing antibody titers against the Alpha, Beta and Delta variants were substantially reduced. S1-reactive antibody levels decreased in 13% of patients, whereas neutralizing antibody titers remained stable for up to 329 days. Patients also had detectable SARS-CoV-2-specific T cells and CD4+ responses correlating with S1-reactive antibody levels, although patients with hematological malignancies had impaired immune responses that were disease and treatment specific, but presented compensatory cellular responses, further supported by clinical recovery in all but one patient. Overall, these findings advance the understanding of the nature and duration of the immune response to SARS-CoV-2 in patients with cancer. Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.
@article{Fendler2021,
abstract = {Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2 positive, 94 were symptomatic and 2 died of COVID-19. In this cohort, 83{\%} patients had S1-reactive antibodies and 82{\%} had neutralizing antibodies against wild type SARS-CoV-2, whereas neutralizing antibody titers against the Alpha, Beta and Delta variants were substantially reduced. S1-reactive antibody levels decreased in 13{\%} of patients, whereas neutralizing antibody titers remained stable for up to 329 days. Patients also had detectable SARS-CoV-2-specific T cells and CD4+ responses correlating with S1-reactive antibody levels, although patients with hematological malignancies had impaired immune responses that were disease and treatment specific, but presented compensatory cellular responses, further supported by clinical recovery in all but one patient. Overall, these findings advance the understanding of the nature and duration of the immune response to SARS-CoV-2 in patients with cancer. Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.},
author = {Fendler, Annika and Au, Lewis and Shepherd, Scott T C and Byrne, Fiona and Cerrone, Maddalena and Boos, Laura Amanda and Rzeniewicz, Karolina and Gordon, William and Shum, Benjamin and Gerard, Camille L and Ward, Barry and Xie, Wenyi and Schmitt, Andreas M and Joharatnam-Hogan, Nalinie and Cornish, Georgina H and Pule, Martin and Mekkaoui, Leila and Ng, Kevin W and Carlyle, Eleanor and Edmonds, Kim and Rosario, Lyra Del and Sarker, Sarah and Lingard, Karla and Mangwende, Mary and Holt, Lucy and Ahmod, Hamid and Stone, Richard and Gomes, Camila and Flynn, Helen R. and Agua-Doce, Ana and Hobson, Philip and Caidan, Simon and Howell, Michael and Wu, Mary and Goldstone, Robert and Crawford, Margaret and Cubitt, Laura and Patel, Harshil and Gavrielides, Mike and Nye, Emma and Snijders, Ambrosius P and MacRae, James I and Nicod, Jerome and Gronthoud, Firza and Shea, Robyn L and Messiou, Christina and Cunningham, David and Chau, Ian and Starling, Naureen and Turner, Nicholas and Welsh, Liam and van As, Nicholas and Jones, Robin L and Droney, Joanne and Banerjee, Susana and Tatham, Kate C and Jhanji, Shaman and O'Brien, Mary and Curtis, Olivia and Harrington, Kevin and Bhide, Shreerang and Bazin, Jessica and Robinson, Anna and Stephenson, Clemency and Slattery, Tim and Khan, Yasir and Tippu, Zayd and Leslie, Isla and Gennatas, Spyridon and Okines, Alicia and Reid, Alison and Young, Kate and Furness, Andrew J S and Pickering, Lisa and Gandhi, Sonia and Gamblin, Steve and Swanton, Charles and Nicholson, Emma and Kumar, Sacheen and Yousaf, Nadia and Wilkinson, Katalin A and Swerdlow, Anthony and Harvey, Ruth and Kassiotis, George and Larkin, James and Wilkinson, Robert J and Turajlic, Samra},
doi = {10.1038/s43018-021-00275-9},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Fendler et al. - 2021 - Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in pat.pdf:pdf},
issn = {2662-1347},
journal = {Nature Cancer},
keywords = {2,Cancer,CoV,OA,SARS,Viral infection,fund{\_}ack,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {oct},
pages = {1321--1337},
publisher = {Nature Publishing Group},
title = {{Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study}},
url = {https://www.nature.com/articles/s43018-021-00275-9},
volume = {2},
year = {2021}
}

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