Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study. Fendler, A., Shepherd, S. T C, Au, L., Wilkinson, K. A, Wu, M., Byrne, F., Cerrone, M., Schmitt, A. M, Joharatnam-Hogan, N., Shum, B., Tippu, Z., Rzeniewicz, K., Boos, L. A., Harvey, R., Carlyle, E., Edmonds, K., Del Rosario, L., Sarker, S., Lingard, K., Mangwende, M., Holt, L., Ahmod, H., Korteweg, J., Foley, T., Bazin, J., Gordon, W., Barber, T., Emslie-Henry, A., Xie, W., Gerard, C. L, Deng, D., Wall, E. C, Agua-Doce, A., Namjou, S., Caidan, S., Gavrielides, M., MacRae, J. I, Kelly, G., Peat, K., Kelly, D., Murra, A., Kelly, K., O'Flaherty, M., Dowdie, L., Ash, N., Gronthoud, F., Shea, R. L, Gardner, G., Murray, D., Kinnaird, F., Cui, W., Pascual, J., Rodney, S., Mencel, J., Curtis, O., Stephenson, C., Robinson, A., Oza, B., Farag, S., Leslie, I., Rogiers, A., Iyengar, S., Ethell, M., Messiou, C., Cunningham, D., Chau, I., Starling, N., Turner, N., Welsh, L., van As, N., Jones, R. L, Droney, J., Banerjee, S., Tatham, K. C, O'Brien, M., Harrington, K., Bhide, S., Okines, A., Reid, A., Young, K., Furness, A. J S, Pickering, L., Swanton, C., Gandhi, S., Gamblin, S., Bauer, D. L V, Kassiotis, G., Kumar, S., Yousaf, N., Jhanji, S., Nicholson, E., Howell, M., Walker, S., Wilkinson, R. J, Larkin, J., & Turajlic, S. Nature Cancer, 2:1305–1320, Nature Publishing Group, oct, 2021. ![Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85% and 59% in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable titers of neutralizing antibodies (NAbT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) versus wild-type (WT) SARS-CoV-2. Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT than those with solid cancers against both SARS-CoV-2 WT and VOC. By comparison with individuals without cancer, patients with hematological, but not solid, malignancies had reduced neutralizing antibody (NAb) responses. Seroconversion showed poor concordance with NAbT against VOC. Previous SARS-CoV-2 infection boosted the NAb response including against VOC, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T cell responses were detected in 80% of patients and were comparable between vaccines or cancer types. Our results have implications for the management of patients with cancer during the ongoing COVID-19 pandemic. Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.
@article{Fendler2021a,
abstract = {Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85{\%} and 59{\%} in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable titers of neutralizing antibodies (NAbT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) versus wild-type (WT) SARS-CoV-2. Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT than those with solid cancers against both SARS-CoV-2 WT and VOC. By comparison with individuals without cancer, patients with hematological, but not solid, malignancies had reduced neutralizing antibody (NAb) responses. Seroconversion showed poor concordance with NAbT against VOC. Previous SARS-CoV-2 infection boosted the NAb response including against VOC, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T cell responses were detected in 80{\%} of patients and were comparable between vaccines or cancer types. Our results have implications for the management of patients with cancer during the ongoing COVID-19 pandemic. Turajlic and colleagues assess longitudinal antibody and cellular immune responses against SARS-CoV-2 variants of concern in patients with cancer, following either recovery from SARS-CoV-2 infection or vaccination, in two back-to-back reports from the CAPTURE study.},
author = {Fendler, Annika and Shepherd, Scott T C and Au, Lewis and Wilkinson, Katalin A and Wu, Mary and Byrne, Fiona and Cerrone, Maddalena and Schmitt, Andreas M and Joharatnam-Hogan, Nalinie and Shum, Benjamin and Tippu, Zayd and Rzeniewicz, Karolina and Boos, Laura Amanda and Harvey, Ruth and Carlyle, Eleanor and Edmonds, Kim and {Del Rosario}, Lyra and Sarker, Sarah and Lingard, Karla and Mangwende, Mary and Holt, Lucy and Ahmod, Hamid and Korteweg, Justine and Foley, Tara and Bazin, Jessica and Gordon, William and Barber, Taja and Emslie-Henry, Andrea and Xie, Wenyi and Gerard, Camille L and Deng, Daqi and Wall, Emma C and Agua-Doce, Ana and Namjou, Sina and Caidan, Simon and Gavrielides, Mike and MacRae, James I and Kelly, Gavin and Peat, Kema and Kelly, Denise and Murra, Aida and Kelly, Kayleigh and O'Flaherty, Molly and Dowdie, Lauren and Ash, Natalie and Gronthoud, Firza and Shea, Robyn L and Gardner, Gail and Murray, Darren and Kinnaird, Fiona and Cui, Wanyuan and Pascual, Javier and Rodney, Simon and Mencel, Justin and Curtis, Olivia and Stephenson, Clemency and Robinson, Anna and Oza, Bhavna and Farag, Sheima and Leslie, Isla and Rogiers, Aljosja and Iyengar, Sunil and Ethell, Mark and Messiou, Christina and Cunningham, David and Chau, Ian and Starling, Naureen and Turner, Nicholas and Welsh, Liam and van As, Nicholas and Jones, Robin L and Droney, Joanne and Banerjee, Susana and Tatham, Kate C and O'Brien, Mary and Harrington, Kevin and Bhide, Shreerang and Okines, Alicia and Reid, Alison and Young, Kate and Furness, Andrew J S and Pickering, Lisa and Swanton, Charles and Gandhi, Sonia and Gamblin, Steve and Bauer, David L V and Kassiotis, George and Kumar, Sacheen and Yousaf, Nadia and Jhanji, Shaman and Nicholson, Emma and Howell, Michael and Walker, Susanna and Wilkinson, Robert J and Larkin, James and Turajlic, Samra},
doi = {10.1038/s43018-021-00274-w},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Fendler et al. - 2021 - Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in pa.pdf:pdf},
issn = {2662-1347},
journal = {Nature Cancer},
keywords = {2,Cancer,CoV,Medical research,OA,OA{\_}PMC,SARS,Vaccines,fund{\_}ack,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {oct},
pages = {1305--1320},
pmid = {34950880},
publisher = {Nature Publishing Group},
title = {{Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study}},
url = {https://www.nature.com/articles/s43018-021-00274-w},
volume = {2},
year = {2021}
}
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