@article{Fendler2022,
abstract = {Summary Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. In the context of the CAPTURE study (NCT03226886), we report immune responses in 80 patients with blood cancer who received a fourth dose of BNT162b2. We measured neutralizing antibody titers (NAbTs) using a live virus microneutralization assay against wild-type (WT), Delta, and Omicron BA.1 and BA.2 and T cell responses against WT and Omicron BA.1 using an activation-induced marker (AIM) assay. The proportion of patients with detectable NAb titers and T cell responses after the fourth vaccine dose increased compared with that after the third vaccine dose. Patients who received B cell-depleting therapies within the 12 months before vaccination have the greatest risk of not having detectable NAbT. In addition, we report immune responses in 57 patients with breakthrough infections after vaccination.},
author = {Fendler, Annika and Shepherd, Scott T C and Au, Lewis and Wu, Mary and Harvey, Ruth and Wilkinson, Katalin A and Schmitt, Andreas M and Tippu, Zayd and Shum, Benjamin and Farag, Sheima and Rogiers, Aljosja and Carlyle, Eleanor and Edmonds, Kim and {Del Rosario}, Lyra and Lingard, Karla and Mangwende, Mary and Holt, Lucy and Ahmod, Hamid and Korteweg, Justine and Foley, Tara and Barber, Taja and Emslie-Henry, Andrea and Caulfield-Lynch, Niamh and Byrne, Fiona and Deng, Daqi and Kjaer, Svend and Song, Ok-Ryul and Queval, Christophe J and Kavanagh, Caitlin and Wall, Emma C and Carr, Edward J and Caidan, Simon and Gavrielides, Mike and MacRae, James I and Kelly, Gavin and Peat, Kema and Kelly, Denise and Murra, Aida and Kelly, Kayleigh and O'Flaherty, Molly and Shea, Robyn L and Gardner, Gail and Murray, Darren and Popat, Sanjay and Yousaf, Nadia and Jhanji, Shaman and Tatham, Kate and Cunningham, David and {Van As}, Nicholas and Young, Kate and Furness, Andrew J S and Pickering, Lisa and Beale, Rupert and Swanton, Charles and Gandhi, Sonia and Gamblin, Steve and Bauer, David L V and Kassiotis, George and Howell, Michael and Nicholson, Emma and Walker, Susanna and Wilkinson, Robert J and Larkin, James and Turajlic, Samra},
doi = {10.1016/j.xcrm.2022.100781},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Fendler et al. - 2022 - Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infecti.pdf:pdf},
issn = {26663791},
journal = {Cell Reports Medicine},
keywords = {COVID-19,OA,SARS-CoV-2,T cells,blood cancer,fund{\_}ack,genomics{\_}fund{\_}ack,neutralizing antibodies,original,variants of concern},
mendeley-tags = {OA,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {oct},
number = {10},
pages = {100781},
pmid = {36240755},
publisher = {Elsevier BV},
title = {{Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer}},
url = {http://www.cell.com/article/S2666379122003366/fulltext http://www.cell.com/article/S2666379122003366/abstract https://www.cell.com/cell-reports-medicine/abstract/S2666-3791(22)00336-6},
volume = {3},
year = {2022}
}

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risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. 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