Influence of computer-aided detection on performance of screening mammography. Fenton, J. J., Taplin, S. H., Carney, P. A., Abraham, L., Sickles, E. A., D'Orsi, C., Berns, E. A., Cutter, G., Hendrick, R. E., Barlow, W. E., & Elmore, J. G. The New England Journal of Medicine, 356(14):1399–1409, April, 2007.
doi  abstract   bibtex   
BACKGROUND: Computer-aided detection identifies suspicious findings on mammograms to assist radiologists. Since the Food and Drug Administration approved the technology in 1998, it has been disseminated into practice, but its effect on the accuracy of interpretation is unclear. METHODS: We determined the association between the use of computer-aided detection at mammography facilities and the performance of screening mammography from 1998 through 2002 at 43 facilities in three states. We had complete data for 222,135 women (a total of 429,345 mammograms), including 2351 women who received a diagnosis of breast cancer within 1 year after screening. We calculated the specificity, sensitivity, and positive predictive value of screening mammography with and without computer-aided detection, as well as the rates of biopsy and breast-cancer detection and the overall accuracy, measured as the area under the receiver-operating-characteristic (ROC) curve. RESULTS: Seven facilities (16%) implemented computer-aided detection during the study period. Diagnostic specificity decreased from 90.2% before implementation to 87.2% after implementation (P\textless0.001), the positive predictive value decreased from 4.1% to 3.2% (P=0.01), and the rate of biopsy increased by 19.7% (P\textless0.001). The increase in sensitivity from 80.4% before implementation of computer-aided detection to 84.0% after implementation was not significant (P=0.32). The change in the cancer-detection rate (including invasive breast cancers and ductal carcinomas in situ) was not significant (4.15 cases per 1000 screening mammograms before implementation and 4.20 cases after implementation, P=0.90). Analyses of data from all 43 facilities showed that the use of computer-aided detection was associated with significantly lower overall accuracy than was nonuse (area under the ROC curve, 0.871 vs. 0.919; P=0.005). CONCLUSIONS: The use of computer-aided detection is associated with reduced accuracy of interpretation of screening mammograms. The increased rate of biopsy with the use of computer-aided detection is not clearly associated with improved detection of invasive breast cancer.
@article{fenton_influence_2007,
	title = {Influence of computer-aided detection on performance of screening mammography},
	volume = {356},
	issn = {1533-4406},
	doi = {10.1056/NEJMoa066099},
	abstract = {BACKGROUND: Computer-aided detection identifies suspicious findings on mammograms to assist radiologists. Since the Food and Drug Administration approved the technology in 1998, it has been disseminated into practice, but its effect on the accuracy of interpretation is unclear.
METHODS: We determined the association between the use of computer-aided detection at mammography facilities and the performance of screening mammography from 1998 through 2002 at 43 facilities in three states. We had complete data for 222,135 women (a total of 429,345 mammograms), including 2351 women who received a diagnosis of breast cancer within 1 year after screening. We calculated the specificity, sensitivity, and positive predictive value of screening mammography with and without computer-aided detection, as well as the rates of biopsy and breast-cancer detection and the overall accuracy, measured as the area under the receiver-operating-characteristic (ROC) curve.
RESULTS: Seven facilities (16\%) implemented computer-aided detection during the study period. Diagnostic specificity decreased from 90.2\% before implementation to 87.2\% after implementation (P{\textless}0.001), the positive predictive value decreased from 4.1\% to 3.2\% (P=0.01), and the rate of biopsy increased by 19.7\% (P{\textless}0.001). The increase in sensitivity from 80.4\% before implementation of computer-aided detection to 84.0\% after implementation was not significant (P=0.32). The change in the cancer-detection rate (including invasive breast cancers and ductal carcinomas in situ) was not significant (4.15 cases per 1000 screening mammograms before implementation and 4.20 cases after implementation, P=0.90). Analyses of data from all 43 facilities showed that the use of computer-aided detection was associated with significantly lower overall accuracy than was nonuse (area under the ROC curve, 0.871 vs. 0.919; P=0.005).
CONCLUSIONS: The use of computer-aided detection is associated with reduced accuracy of interpretation of screening mammograms. The increased rate of biopsy with the use of computer-aided detection is not clearly associated with improved detection of invasive breast cancer.},
	language = {eng},
	number = {14},
	journal = {The New England Journal of Medicine},
	author = {Fenton, Joshua J. and Taplin, Stephen H. and Carney, Patricia A. and Abraham, Linn and Sickles, Edward A. and D'Orsi, Carl and Berns, Eric A. and Cutter, Gary and Hendrick, R. Edward and Barlow, William E. and Elmore, Joann G.},
	month = apr,
	year = {2007},
	pmid = {17409321},
	pmcid = {PMC3182841},
	keywords = {Adult, Biopsy, Breast, Breast Neoplasms, Carcinoma in Situ, Carcinoma, Ductal, Breast, Chi-Square Distribution, False Positive Reactions, Female, Health Care Surveys, Humans, Logistic Models, Mammography, Middle Aged, Radiographic Image Interpretation, Computer-Assisted, Registries, Sensitivity and Specificity, United States},
	pages = {1399--1409},
}
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