Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6. Feo, M. L., Gross, M. S, McGarrigle, B. P, Eljarrat, E., Barceló, D., Aga, D. S, & Olson, J. R Environmental health perspectives, 121(4):440--6, 446e1--7, April, 2013.
Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6. [link]Paper  doi  abstract   bibtex   
Previous studies have indicated that cytochrome P450s (CYPs) are involved in the metabolism of polybrominated diphenyl ether (PBDE) flame retardants in humans, resulting in the formation of hydroxylated PBDEs (OH-PBDEs) that are potentially more toxic than the parent PBDEs. However, the specific enzymes responsible for the formation of OH-PBDEs are unknown.
@article{feo_biotransformation_2013,
	title = {Biotransformation of {BDE}-47 to potentially toxic metabolites is predominantly mediated by human {CYP}2B6.},
	volume = {121},
	issn = {1552-9924},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3620761&tool=pmcentrez&rendertype=abstract},
	doi = {10.1289/ehp.1205446},
	abstract = {Previous studies have indicated that cytochrome P450s (CYPs) are involved in the metabolism of polybrominated diphenyl ether (PBDE) flame retardants in humans, resulting in the formation of hydroxylated PBDEs (OH-PBDEs) that are potentially more toxic than the parent PBDEs. However, the specific enzymes responsible for the formation of OH-PBDEs are unknown.},
	number = {4},
	journal = {Environmental health perspectives},
	author = {Feo, Maria Luisa and Gross, Michael S and McGarrigle, Barbara P and Eljarrat, Ethel and Barceló, Damià and Aga, Diana S and Olson, James R},
	month = apr,
	year = {2013},
	pmid = {23249762},
	keywords = {Flame retardants},
	pages = {440--6, 446e1--7}
}
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