The new approach to evaluation of endothelium dysfunction: Detection of number of circulating endothelium cells using flow cytometry technique. Feoklistova, V., Vavilkova, T., Sirotkina, O., Boldueva, S., Gaikovaia, L., Leonova, I., Laskovets, A., & Ermakov, A. Klinichescheskaya Laboratornaya Diagnostika, 2015-January(4):23-26, Izdatel'stvo Meditsina, 2015. cited By 1
The new approach to evaluation of endothelium dysfunction: Detection of number of circulating endothelium cells using flow cytometry technique [link]Paper  abstract   bibtex   
The endothelium dysfunction takes leading place in pathogenesis of development of cardiovascular diseases. The circulating endothelium cells of peripheral blood can act as a direct cell marker of damage and remodeling of endothelium. The study was carried out to develop a new approach to diagnose of endothelium dysfunction by force of determination of number of circulating endothelium cells using flow cytometry technique and to apply determination of circulating endothelium cells for evaluation of risk of development of ischemic heart disease in women of young and middle age. The study embraced 62 female patients with angiography confirmed ischemic heart disease, exertional angina pectoris at the level of functional class I-11 (mean age 51±6 years) and 49 women without anamnesis of ischemic heart disease (mean age 52±9 years). The occurrence of more than three circulating endothelium cells by 3x105 leukocytes in peripheral blood increases relative risk of development of ischemic heart disease up to 4 times in women of young and middle age and risk of development of acute myocardial infarction up to 8 times in women with ischemic heart disease. The study demonstrated possibility to apply flow cytometry technique to quantitatively specify circulating endothelium cells in peripheral blood and forecast risk of development of ischemic heart disease in women of young and middle age depending on level of circulating endothelium cells.
@ARTICLE{Feoklistova201523,
author={Feoklistova, V.S. and Vavilkova, T.V. and Sirotkina, O.V.I. and Boldueva, S.A. and Gaikovaia, L.B. and Leonova, I.A. and Laskovets, A.B. and Ermakov, A.I.},
title={The new approach to evaluation of endothelium dysfunction: Detection of number of circulating endothelium cells using flow cytometry technique},
journal={Klinichescheskaya Laboratornaya Diagnostika},
year={2015},
volume={2015-January},
number={4},
pages={23-26},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938916243&partnerID=40&md5=3c68eb426c732e81966b1d731ec96742},
affiliation={I.I. Mechnikov North-Western State Medical, University of Minzdrav of Russia, St. Petersburg, 191015, Russian Federation; V.A. Almazov Federal Medical Research Center of Minzdrav of Russia, St. Petersburg, 197341, Russian Federation; B.P. Konstantinov St. Petersburg Institute of Nuclear Physics, Gatchina, Leningradskaia Oblast, 188350, Russian Federation},
abstract={The endothelium dysfunction takes leading place in pathogenesis of development of cardiovascular diseases. The circulating endothelium cells of peripheral blood can act as a direct cell marker of damage and remodeling of endothelium. The study was carried out to develop a new approach to diagnose of endothelium dysfunction by force of determination of number of circulating endothelium cells using flow cytometry technique and to apply determination of circulating endothelium cells for evaluation of risk of development of ischemic heart disease in women of young and middle age. The study embraced 62 female patients with angiography confirmed ischemic heart disease, exertional angina pectoris at the level of functional class I-11 (mean age 51±6 years) and 49 women without anamnesis of ischemic heart disease (mean age 52±9 years). The occurrence of more than three circulating endothelium cells by 3x105 leukocytes in peripheral blood increases relative risk of development of ischemic heart disease up to 4 times in women of young and middle age and risk of development of acute myocardial infarction up to 8 times in women with ischemic heart disease. The study demonstrated possibility to apply flow cytometry technique to quantitatively specify circulating endothelium cells in peripheral blood and forecast risk of development of ischemic heart disease in women of young and middle age depending on level of circulating endothelium cells.},
author_keywords={Circulating endothelium cells: flow cytometry;  Endothelium dysfunction;  Ischemic heart disease},
publisher={Izdatel'stvo Meditsina},
issn={08692084},
pubmed_id={26189287},
language={Russian},
abbrev_source_title={Klin. Lab. Diagn.},
document_type={Article},
source={Scopus},
}

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