@article{RN6124,
   author = {Ferguson, S. D. and Xiu, J. and Weathers, S. P. and Zhou, S. and Kesari, S. and Weiss, S. E. and Verhaak, R. G. and Hohl, R. J. and Barger, G. R. and Reddy, S. K. and Heimberger, A. B.},
   title = {GBM-associated mutations and altered protein expression are more common in young patients},
   journal = {Oncotarget},
   volume = {7},
   number = {43},
   pages = {69466-69478},
   note = {1949-2553
Ferguson, Sherise D
Xiu, Joanne
Weathers, Shiao-Pei
Zhou, Shouhao
Kesari, Santosh
Weiss, Stephanie E
Verhaak, Roeland G
Hohl, Raymond J
Barger, Geoffrey R
Reddy, Sandeep K
Heimberger, Amy B
P30 CA016672/CA/NCI NIH HHS/United States
P50 CA127001/CA/NCI NIH HHS/United States
R01 CA120813/CA/NCI NIH HHS/United States
Journal Article
United States
2016/09/01
Oncotarget. 2016 Oct 25;7(43):69466-69478. doi: 10.18632/oncotarget.11617.},
   abstract = {BACKGROUND: Geriatric glioblastoma (GBM) patients have a poorer prognosis than younger patients, but IDH1/2 mutations (more common in younger patients) confer a favorable prognosis. We compared key GBM molecular alterations between an elderly (age ≥ 70) and younger (18 < = age < = 45) cohort to explore potential therapeutic opportunities. RESULTS: Alterations more prevalent in the young GBM cohort compared to the older cohort (P < 0.05) were: overexpression of ALK, RRM1, TUBB3 and mutation of ATRX, BRAF, IDH1, and TP53. However, PTEN mutation was significantly more frequent in older patients. Among patients with wild-type IDH1/2 status, TOPO1 expression was higher in younger patients, whereas MGMT methylation was more frequent in older patients. Within the molecularly-defined IDH wild-type GBM cohort, younger patients had significantly more mutations in PDGFRA, PTPN11, SMARCA4, BRAF and TP53. METHODS: GBMs from 178 elderly patients and 197 young patients were analyzed using DNA sequencing, immunohistochemistry, in situ hybridization, and MGMT-methylation assay to ascertain mutational and amplification/expressional status. CONCLUSIONS: Significant molecular differences occurred in GBMs from elderly and young patients. Except for the older cohort's more frequent PTEN mutation and MGMT methylation, younger patients had a higher frequency of potential therapeutic targets.},
   keywords = {Adult
Age Factors
Aged
Aging/*genetics
Biomarkers, Tumor/*genetics/metabolism
Brain Neoplasms/*genetics/metabolism
Cohort Studies
DNA Methylation
DNA Mutational Analysis/methods
ErbB Receptors/genetics/metabolism
Gene Expression Regulation, Neoplastic
Glioblastoma/*genetics/metabolism
Humans
*Mutation
Tumor Suppressor Protein p53/genetics/metabolism
DNA sequencing
Gbm
mutational analysis},
   ISSN = {1949-2553},
   DOI = {10.18632/oncotarget.11617},
   year = {2016},
   type = {Journal Article}
}

{"_id":"ZQktNWiCTTZCfbKX2","bibbaseid":"ferguson-xiu-weathers-zhou-kesari-weiss-verhaak-hohl-etal-gbmassociatedmutationsandalteredproteinexpressionaremorecommoninyoungpatients-2016","authorIDs":["5dce3b23dcea22df0100007c","5dec52fce16431f2010000c9","5dec5944e16431f2010000fa","5e0a5e7ace3ebce40100010e","5e2ff5be5bfc8ede0100003b","c8zrScQz6casKGL4t"],"author_short":["Ferguson, S. D.","Xiu, J.","Weathers, S. P.","Zhou, S.","Kesari, S.","Weiss, S. E.","Verhaak, R. G.","Hohl, R. J.","Barger, G. R.","Reddy, S. K.","Heimberger, A. B."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Ferguson"],"firstnames":["S.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Xiu"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Weathers"],"firstnames":["S.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Zhou"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Kesari"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Weiss"],"firstnames":["S.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Verhaak"],"firstnames":["R.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Hohl"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Barger"],"firstnames":["G.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Reddy"],"firstnames":["S.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Heimberger"],"firstnames":["A.","B."],"suffixes":[]}],"title":"GBM-associated mutations and altered protein expression are more common in young patients","journal":"Oncotarget","volume":"7","number":"43","pages":"69466-69478","note":"1949-2553 Ferguson, Sherise D Xiu, Joanne Weathers, Shiao-Pei Zhou, Shouhao Kesari, Santosh Weiss, Stephanie E Verhaak, Roeland G Hohl, Raymond J Barger, Geoffrey R Reddy, Sandeep K Heimberger, Amy B P30 CA016672/CA/NCI NIH HHS/United States P50 CA127001/CA/NCI NIH HHS/United States R01 CA120813/CA/NCI NIH HHS/United States Journal Article United States 2016/09/01 Oncotarget. 2016 Oct 25;7(43):69466-69478. doi: 10.18632/oncotarget.11617.","abstract":"BACKGROUND: Geriatric glioblastoma (GBM) patients have a poorer prognosis than younger patients, but IDH1/2 mutations (more common in younger patients) confer a favorable prognosis. We compared key GBM molecular alterations between an elderly (age ≥ 70) and younger (18 < = age < = 45) cohort to explore potential therapeutic opportunities. RESULTS: Alterations more prevalent in the young GBM cohort compared to the older cohort (P < 0.05) were: overexpression of ALK, RRM1, TUBB3 and mutation of ATRX, BRAF, IDH1, and TP53. However, PTEN mutation was significantly more frequent in older patients. Among patients with wild-type IDH1/2 status, TOPO1 expression was higher in younger patients, whereas MGMT methylation was more frequent in older patients. Within the molecularly-defined IDH wild-type GBM cohort, younger patients had significantly more mutations in PDGFRA, PTPN11, SMARCA4, BRAF and TP53. METHODS: GBMs from 178 elderly patients and 197 young patients were analyzed using DNA sequencing, immunohistochemistry, in situ hybridization, and MGMT-methylation assay to ascertain mutational and amplification/expressional status. CONCLUSIONS: Significant molecular differences occurred in GBMs from elderly and young patients. Except for the older cohort's more frequent PTEN mutation and MGMT methylation, younger patients had a higher frequency of potential therapeutic targets.","keywords":"Adult Age Factors Aged Aging/*genetics Biomarkers, Tumor/*genetics/metabolism Brain Neoplasms/*genetics/metabolism Cohort Studies DNA Methylation DNA Mutational Analysis/methods ErbB Receptors/genetics/metabolism Gene Expression Regulation, Neoplastic Glioblastoma/*genetics/metabolism Humans *Mutation Tumor Suppressor Protein p53/genetics/metabolism DNA sequencing Gbm mutational analysis","issn":"1949-2553","doi":"10.18632/oncotarget.11617","year":"2016","bibtex":"@article{RN6124,\n author = {Ferguson, S. D. and Xiu, J. and Weathers, S. P. and Zhou, S. and Kesari, S. and Weiss, S. E. and Verhaak, R. G. and Hohl, R. J. and Barger, G. R. and Reddy, S. K. and Heimberger, A. B.},\n title = {GBM-associated mutations and altered protein expression are more common in young patients},\n journal = {Oncotarget},\n volume = {7},\n number = {43},\n pages = {69466-69478},\n note = {1949-2553\nFerguson, Sherise D\nXiu, Joanne\nWeathers, Shiao-Pei\nZhou, Shouhao\nKesari, Santosh\nWeiss, Stephanie E\nVerhaak, Roeland G\nHohl, Raymond J\nBarger, Geoffrey R\nReddy, Sandeep K\nHeimberger, Amy B\nP30 CA016672/CA/NCI NIH HHS/United States\nP50 CA127001/CA/NCI NIH HHS/United States\nR01 CA120813/CA/NCI NIH HHS/United States\nJournal Article\nUnited States\n2016/09/01\nOncotarget. 2016 Oct 25;7(43):69466-69478. doi: 10.18632/oncotarget.11617.},\n abstract = {BACKGROUND: Geriatric glioblastoma (GBM) patients have a poorer prognosis than younger patients, but IDH1/2 mutations (more common in younger patients) confer a favorable prognosis. We compared key GBM molecular alterations between an elderly (age ≥ 70) and younger (18 < = age < = 45) cohort to explore potential therapeutic opportunities. RESULTS: Alterations more prevalent in the young GBM cohort compared to the older cohort (P < 0.05) were: overexpression of ALK, RRM1, TUBB3 and mutation of ATRX, BRAF, IDH1, and TP53. However, PTEN mutation was significantly more frequent in older patients. Among patients with wild-type IDH1/2 status, TOPO1 expression was higher in younger patients, whereas MGMT methylation was more frequent in older patients. Within the molecularly-defined IDH wild-type GBM cohort, younger patients had significantly more mutations in PDGFRA, PTPN11, SMARCA4, BRAF and TP53. METHODS: GBMs from 178 elderly patients and 197 young patients were analyzed using DNA sequencing, immunohistochemistry, in situ hybridization, and MGMT-methylation assay to ascertain mutational and amplification/expressional status. CONCLUSIONS: Significant molecular differences occurred in GBMs from elderly and young patients. Except for the older cohort's more frequent PTEN mutation and MGMT methylation, younger patients had a higher frequency of potential therapeutic targets.},\n keywords = {Adult\nAge Factors\nAged\nAging/*genetics\nBiomarkers, Tumor/*genetics/metabolism\nBrain Neoplasms/*genetics/metabolism\nCohort Studies\nDNA Methylation\nDNA Mutational Analysis/methods\nErbB Receptors/genetics/metabolism\nGene Expression Regulation, Neoplastic\nGlioblastoma/*genetics/metabolism\nHumans\n*Mutation\nTumor Suppressor Protein p53/genetics/metabolism\nDNA sequencing\nGbm\nmutational analysis},\n ISSN = {1949-2553},\n DOI = {10.18632/oncotarget.11617},\n year = {2016},\n type = {Journal Article}\n}\n\n","author_short":["Ferguson, S. D.","Xiu, J.","Weathers, S. P.","Zhou, S.","Kesari, S.","Weiss, S. E.","Verhaak, R. G.","Hohl, R. J.","Barger, G. R.","Reddy, S. K.","Heimberger, A. 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