@article{
 title = {Gene regulation mediated by calcium signals in T lymphocytes},
 type = {article},
 year = {2001},
 identifiers = {[object Object]},
 keywords = {ca2+ entry,cells,inositol trisphosphate,intracellular calcium,nf-at,plasma-membrane,resonance energy-transfer,severe combined immunodeficiency,store depletion,transcription factors},
 pages = {316-324},
 volume = {2},
 id = {10d2870c-f6ae-30af-8123-33dd77c9af8b},
 created = {2018-03-05T02:58:05.346Z},
 file_attached = {true},
 profile_id = {fc9ef84f-888b-33fd-b1d3-fbf022f2f0c8},
 group_id = {21bf6821-cbba-3be9-9d50-072f76d57584},
 last_modified = {2018-03-05T02:58:05.442Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Feske2001},
 private_publication = {false},
 abstract = {Modulation of many signaling pathways in antigen-stimulated T and B cells results in global changes in gene expression. Here we investigate the contribution of calcium signaling to gene expression in T cells using cell lines from two severe-combined immunodeficiency patients with several cytokine deficiencies and diminished activation of the transcription factor NFAT nuclear factor of activated T cells. These T cells show a strong defect in transmembrane calcium influx that is also apparent in their B cells and fibroblasts. DNA microarray analysis of calcium entry-deficient and control T cells shows that Ca2+ signals both activate and repress gene expression and are largely transduced through the phosphatase calcineurin. We demonstrate an elaborate network of signaling pathways downstream of the T cell receptor, explaining the complexity of changes in gene expression during T cell activation.},
 bibtype = {article},
 author = {Feske, S and Giltnane, J and Dolmetsch, R and Staudt, L M and Rao, A},
 journal = {Nat Immunol},
 number = {4}
}

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