Change in Serum Lactate Dehydrogenase Is Associated with Outcome of Patients with Advanced-stage NSCLC Treated with Erlotinib. Fiala, O., Pesek, M., Finek, J., Topolcan, O., Racek, J., Svaton, M., Kucera, R., Minarik, M., Benesova, L., Bortlicek, Z., Chloupkova, R., Poprach, A., & Buchler, T. Anticancer research, 36(5):2459--2465, May, 2016.
abstract   bibtex   
BACKGROUND Serum lactate dehydrogenase (LDH) has been reported as a prognostic biomarker in malignant diseases. However, little is known on the dynamics of serum LDH levels during systemic treatment. We focused on the association of changes in serum LDH with outcome of patients with advanced-stage non-small cell lung cancer (NSCLC) treated with erlotinib. PATIENTS AND METHODS Clinical data of 309 patients were analyzed. Serum samples were collected within one week before initiation and after one month of treatment. RESULTS The change in serum LDH during the first month of erlotinib treatment was independently associated with disease control rate (p=0.006), progression-free survival (PFS) (p=0.010) and overall survival (OS) (p\textless0.001). CONCLUSION LDH is a commonly used serum biomarker, that is cheap and easy to detect. The results of our study suggest that the change in LDH serum level during the first month is a surrogate marker on the efficacy of erlotinib in patients with advanced NSCLC.
@article{fiala_change_2016,
	title = {Change in {Serum} {Lactate} {Dehydrogenase} {Is} {Associated} with {Outcome} of {Patients} with {Advanced}-stage {NSCLC} {Treated} with {Erlotinib}},
	volume = {36},
	issn = {1791-7530},
	abstract = {BACKGROUND

Serum lactate dehydrogenase (LDH) has been reported as a prognostic biomarker in malignant diseases. However, little is known on the dynamics of serum LDH levels during systemic treatment. We focused on the association of changes in serum LDH with outcome of patients with advanced-stage non-small cell lung cancer (NSCLC) treated with erlotinib.


PATIENTS AND METHODS

Clinical data of 309 patients were analyzed. Serum samples were collected within one week before initiation and after one month of treatment.


RESULTS

The change in serum LDH during the first month of erlotinib treatment was independently associated with disease control rate (p=0.006), progression-free survival (PFS) (p=0.010) and overall survival (OS) (p{\textless}0.001).


CONCLUSION

LDH is a commonly used serum biomarker, that is cheap and easy to detect. The results of our study suggest that the change in LDH serum level during the first month is a surrogate marker on the efficacy of erlotinib in patients with advanced NSCLC.},
	number = {5},
	journal = {Anticancer research},
	author = {Fiala, Ondrej and Pesek, Milos and Finek, Jindrich and Topolcan, Ondrej and Racek, Jaroslav and Svaton, Martin and Kucera, Radek and Minarik, Marek and Benesova, Lucie and Bortlicek, Zbynek and Chloupkova, Renata and Poprach, Alexandr and Buchler, Tomas},
	month = may,
	year = {2016},
	pmid = {27127158},
	keywords = {Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Erlotinib Hydrochloride, Female, Humans, L-Lactate Dehydrogenase, Lung Neoplasms, Male, Middle Aged, Retrospective Studies, Treatment Outcome},
	pages = {2459--2465}
}
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