Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial. Fielding, R. A., Guralnik, J. M., King, A. C., Pahor, M., McDermott, M. M., Tudor-Locke, C., Manini, T. M., Glynn, N. W., Marsh, A. P., Axtell, R. S., Hsu, F., Rejeski, W. J., & for the LIFE study group PLOS ONE, 12(8):1–20, August, 2017. Citation Key Alias: lens.org/051-878-134-389-919, pop00016 tex.type: [object Object]
Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial [link]Paper  doi  abstract   bibtex   
Understanding the minimal dose of physical activity required to achieve improvement in physical functioning and reductions in disability risk is necessary to inform public health recommendations. To examine the effect of physical activity dose on changes in physical functioning and the onset of major mobility disability in The Lifestyle Interventions and Independence for Elders (LIFE) Study. We conducted a multicenter single masked randomized controlled trial that enrolled participants in 2010 and 2011 and followed them for an average of 2.6 years. 1,635 sedentary men and women aged 70-89 years who had functional limitations were randomized to a structured moderate intensity walking, resistance, and flexibility physical activity program or a health education program. Physical activity dose was assessed by 7-day accelerometry and self-report at baseline and 24 months. Outcomes included the 400 m walk gait speed, the Short Physical Performance Battery (SPPB), assessed at baseline, 6, 12, and 24 months, and onset of major mobility disability (objectively defined by loss of ability to walk 400 m in 15 min). When the physical activity arm or the entire sample were stratified by change in physical activity from baseline to 24 months, there was a dose-dependent increase in the change in gait speed and SPPB from baseline at 6, 12, and 24 months. In addition, the magnitude of change in physical activity over 24 months was related to the reduction in the onset of major mobility disability (overall P ¡ 0.001) (highest versus the lowest quartile of physical activity change HR 0.23 ((95% CI: 0.10-0.52) P = 0.001) in the physical activity arm. We observed a dose-dependent effect of objectively monitored physical activity on physical functioning and onset of major mobility disability. Relatively small increases (¿ 48 minutes per week) in regular physical activity participation had significant and clinically meaningful effects on these outcomes.
@article{fielding_dose_2017,
	title = {Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: {Results} from the {LIFE} study randomized trial},
	volume = {12},
	issn = {1932-6203},
	shorttitle = {Dose of physical activity, physical functioning and disability risk in mobility-limited older adults},
	url = {https://dx.plos.org/10.1371/journal.pone.0182155},
	doi = {fede},
	abstract = {Understanding the minimal dose of physical activity required to achieve improvement in physical functioning and reductions in disability risk is necessary to inform public health recommendations. To examine the effect of physical activity dose on changes in physical functioning and the onset of major mobility disability in The Lifestyle Interventions and Independence for Elders (LIFE) Study. We conducted a multicenter single masked randomized controlled trial that enrolled participants in 2010 and 2011 and followed them for an average of 2.6 years. 1,635 sedentary men and women aged 70-89 years who had functional limitations were randomized to a structured moderate intensity walking, resistance, and flexibility physical activity program or a health education program. Physical activity dose was assessed by 7-day accelerometry and self-report at baseline and 24 months. Outcomes included the 400 m walk gait speed, the Short Physical Performance Battery (SPPB), assessed at baseline, 6, 12, and 24 months, and onset of major mobility disability (objectively defined by loss of ability to walk 400 m in 15 min). When the physical activity arm or the entire sample were stratified by change in physical activity from baseline to 24 months, there was a dose-dependent increase in the change in gait speed and SPPB from baseline at 6, 12, and 24 months. In addition, the magnitude of change in physical activity over 24 months was related to the reduction in the onset of major mobility disability (overall P ¡ 0.001) (highest versus the lowest quartile of physical activity change HR 0.23 ((95\% CI: 0.10-0.52) P = 0.001) in the physical activity arm. We observed a dose-dependent effect of objectively monitored physical activity on physical functioning and onset of major mobility disability. Relatively small increases (¿ 48 minutes per week) in regular physical activity participation had significant and clinically meaningful effects on these outcomes.},
	language = {en},
	number = {8},
	urldate = {2019-10-03},
	journal = {PLOS ONE},
	author = {Fielding, Roger A. and Guralnik, Jack M. and King, Abby C. and Pahor, Marco and McDermott, Mary M. and Tudor-Locke, Catrine and Manini, Todd M. and Glynn, Nancy W. and Marsh, Anthony P. and Axtell, Robert S. and Hsu, Fang-Chi and Rejeski, W. Jack and {for the LIFE study group}},
	editor = {Stepto, Nigel Keith},
	month = aug,
	year = {2017},
	note = {Citation Key Alias: lens.org/051-878-134-389-919, pop00016
tex.type: [object Object]},
	keywords = {dept.hms},
	pages = {1--20}
}

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