A multigene RT-PCR assay used to predict recurrence in early breast cancer: two presentations with contradictory results. Fiets, W. E & Nortier, J. W. Breast Cancer Research, 6(5):185--187, 2004.
A multigene RT-PCR assay used to predict recurrence in early breast cancer: two presentations with contradictory results [link]Paper  doi  abstract   bibtex   
During the 2003 San Antonio Breast Cancer Symposium two studies were presented that were designed to validate a recurrence score, derived from a 21-gene RT-PCR assay, in patients with axillary node-negative breast cancer. This recurrence score was highly predictive for the risk of recurrence in 668 patients treated in a large multicenter trial with adjuvant tamoxifen. However, no prognostic value was found in a small group of patients who were retrospectively selected in a single institution and who did not receive any adjuvant systemic therapy. Further validation is needed to establish the prognostic and predictive role of this assay in clinical management.
@article{fiets_multigene_2004,
	title = {A multigene {RT}-{PCR} assay used to predict recurrence in early breast cancer: two presentations with contradictory results},
	volume = {6},
	issn = {1465-5411},
	shorttitle = {A multigene {RT}-{PCR} assay used to predict recurrence in early breast cancer},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549172/},
	doi = {10.1186/bcr911},
	abstract = {During the 2003 San Antonio Breast Cancer Symposium two studies were presented that were designed to validate a recurrence score, derived from a 21-gene RT-PCR assay, in patients with axillary node-negative breast cancer. This recurrence score was highly predictive for the risk of recurrence in 668 patients treated in a large multicenter trial with adjuvant tamoxifen. However, no prognostic value was found in a small group of patients who were retrospectively selected in a single institution and who did not receive any adjuvant systemic therapy. Further validation is needed to establish the prognostic and predictive role of this assay in clinical management.},
	number = {5},
	urldate = {2013-04-21},
	journal = {Breast Cancer Research},
	author = {Fiets, Willem E and Nortier, Johan WR},
	year = {2004},
	pmid = {15318922},
	pmcid = {PMC549172},
	pages = {185--187},
	file = {PubMed Central Full Text PDF:files/38460/Fiets and Nortier - 2004 - A multigene RT-PCR assay used to predict recurrenc.pdf:application/pdf}
}

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