@article{RN6103,
   author = {Figueroa, J. and Phillips, L. M. and Shahar, T. and Hossain, A. and Gumin, J. and Kim, H. and Bean, A. J. and Calin, G. A. and Fueyo, J. and Walters, E. T. and Kalluri, R. and Verhaak, R. G. and Lang, F. F.},
   title = {Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587},
   journal = {Cancer Res},
   volume = {77},
   number = {21},
   pages = {5808-5819},
   note = {1538-7445
Figueroa, Javier
Phillips, Lynette M
Shahar, Tal
Hossain, Anwar
Gumin, Joy
Kim, Hoon
Bean, Andrew J
Calin, George A
Fueyo, Juan
Walters, Edgar T
Kalluri, Raghu
Verhaak, Roel G
Lang, Frederick F
P30 CA016672/CA/NCI NIH HHS/United States
UH2 TR000943/TR/NCATS NIH HHS/United States
R01 CA115729/CA/NCI NIH HHS/United States
R01 NS091759/NS/NINDS NIH HHS/United States
R01 CA182905/CA/NCI NIH HHS/United States
P50 CA127001/CA/NCI NIH HHS/United States
Journal Article
United States
2017/09/01
Cancer Res. 2017 Nov 1;77(21):5808-5819. doi: 10.1158/0008-5472.CAN-16-2524. Epub 2017 Aug 30.},
   abstract = {Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells (GSC). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts. Analysis of the exosomal content identified miR-1587 as a mediator of the exosomal effects on GSCs, in part via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1. Our results illuminate the tumor-supporting role for GA-hMSCs by identifying GA-hMSC-derived exosomes in the intercellular transfer of specific miRNA that enhance the aggressiveness of glioblastoma. Cancer Res; 77(21); 5808-19. ©2017 AACR.},
   keywords = {Animals
Blotting, Western
*Cell Transformation, Neoplastic
Cells, Cultured
Exosomes/*genetics/metabolism/ultrastructure
Gene Expression Profiling/methods
Gene Expression Regulation, Neoplastic
Glioma/*genetics/metabolism/pathology
Humans
Mesenchymal Stem Cells/*metabolism
Mice, Nude
MicroRNAs/*genetics
Microscopy, Electron
Neoplastic Stem Cells/*metabolism/transplantation
Nuclear Receptor Co-Repressor 1/genetics/metabolism
Stem Cell Transplantation/methods
Transplantation, Heterologous},
   ISSN = {0008-5472 (Print)
0008-5472},
   DOI = {10.1158/0008-5472.Can-16-2524},
   year = {2017},
   type = {Journal Article}
}

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F."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Figueroa"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Phillips"],"firstnames":["L.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Shahar"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Hossain"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Gumin"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Kim"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Bean"],"firstnames":["A.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Calin"],"firstnames":["G.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Fueyo"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Walters"],"firstnames":["E.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Kalluri"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Verhaak"],"firstnames":["R.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Lang"],"firstnames":["F.","F."],"suffixes":[]}],"title":"Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587","journal":"Cancer Res","volume":"77","number":"21","pages":"5808-5819","note":"1538-7445 Figueroa, Javier Phillips, Lynette M Shahar, Tal Hossain, Anwar Gumin, Joy Kim, Hoon Bean, Andrew J Calin, George A Fueyo, Juan Walters, Edgar T Kalluri, Raghu Verhaak, Roel G Lang, Frederick F P30 CA016672/CA/NCI NIH HHS/United States UH2 TR000943/TR/NCATS NIH HHS/United States R01 CA115729/CA/NCI NIH HHS/United States R01 NS091759/NS/NINDS NIH HHS/United States R01 CA182905/CA/NCI NIH HHS/United States P50 CA127001/CA/NCI NIH HHS/United States Journal Article United States 2017/09/01 Cancer Res. 2017 Nov 1;77(21):5808-5819. doi: 10.1158/0008-5472.CAN-16-2524. Epub 2017 Aug 30.","abstract":"Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells (GSC). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts. Analysis of the exosomal content identified miR-1587 as a mediator of the exosomal effects on GSCs, in part via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1. Our results illuminate the tumor-supporting role for GA-hMSCs by identifying GA-hMSC-derived exosomes in the intercellular transfer of specific miRNA that enhance the aggressiveness of glioblastoma. Cancer Res; 77(21); 5808-19. ©2017 AACR.","keywords":"Animals Blotting, Western *Cell Transformation, Neoplastic Cells, Cultured Exosomes/*genetics/metabolism/ultrastructure Gene Expression Profiling/methods Gene Expression Regulation, Neoplastic Glioma/*genetics/metabolism/pathology Humans Mesenchymal Stem Cells/*metabolism Mice, Nude MicroRNAs/*genetics Microscopy, Electron Neoplastic Stem Cells/*metabolism/transplantation Nuclear Receptor Co-Repressor 1/genetics/metabolism Stem Cell Transplantation/methods Transplantation, Heterologous","issn":"0008-5472 (Print) 0008-5472","doi":"10.1158/0008-5472.Can-16-2524","year":"2017","bibtex":"@article{RN6103,\n author = {Figueroa, J. and Phillips, L. M. and Shahar, T. and Hossain, A. and Gumin, J. and Kim, H. and Bean, A. J. and Calin, G. A. and Fueyo, J. and Walters, E. T. and Kalluri, R. and Verhaak, R. G. and Lang, F. F.},\n title = {Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587},\n journal = {Cancer Res},\n volume = {77},\n number = {21},\n pages = {5808-5819},\n note = {1538-7445\nFigueroa, Javier\nPhillips, Lynette M\nShahar, Tal\nHossain, Anwar\nGumin, Joy\nKim, Hoon\nBean, Andrew J\nCalin, George A\nFueyo, Juan\nWalters, Edgar T\nKalluri, Raghu\nVerhaak, Roel G\nLang, Frederick F\nP30 CA016672/CA/NCI NIH HHS/United States\nUH2 TR000943/TR/NCATS NIH HHS/United States\nR01 CA115729/CA/NCI NIH HHS/United States\nR01 NS091759/NS/NINDS NIH HHS/United States\nR01 CA182905/CA/NCI NIH HHS/United States\nP50 CA127001/CA/NCI NIH HHS/United States\nJournal Article\nUnited States\n2017/09/01\nCancer Res. 2017 Nov 1;77(21):5808-5819. doi: 10.1158/0008-5472.CAN-16-2524. Epub 2017 Aug 30.},\n abstract = {Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells (GSC). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts. Analysis of the exosomal content identified miR-1587 as a mediator of the exosomal effects on GSCs, in part via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1. Our results illuminate the tumor-supporting role for GA-hMSCs by identifying GA-hMSC-derived exosomes in the intercellular transfer of specific miRNA that enhance the aggressiveness of glioblastoma. 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