Intestinal and Peripheral Immune Response to MON810 Maize Ingestion in Weaning and Old Mice. Finamore, A., Roselli, M., Britti, S., Monastra, G., Ambra, R., Turrini, A., & Mengheri, E. Journal Of Agricultural And Food Chemistry, 56(23):11533-11539, American Chemical Society, 2008.
abstract   bibtex   
This study evaluated the gut and peripheral immune response to genetically modified (GM) maize in mice in vulnerable conditions. Weaning and old mice were fed a diet containing MON810 or its parental control maize or a pellet diet containing a GM-free maize for 30 and 90 days. The immunophenotype of intestinal intraepithelial, spleen, and blood lymphocytes of control maize fed mice was similar to that of pellet fed mice. As compared to control maize, MON810 maize induced alterations in the percentage of T and B cells and of CD4+, CD8+, γδT, and αβT subpopulations of weaning and old mice fed for 30 or 90 days, respectively, at the gut and peripheral sites. An increase of serum IL-6, IL-13, IL-12p70, and MIP-1β after MON810 feeding was also found. These results suggest the importance of the gut and peripheral immune response to GM crop ingestion as well as the age of the consumer in the GMO safety evaluation.
@article{
 title = {Intestinal and Peripheral Immune Response to MON810 Maize Ingestion in Weaning and Old Mice},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 pages = {11533-11539},
 volume = {56},
 websites = {http://dx.doi.org/10.1021/jf802059w},
 publisher = {American Chemical Society},
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 created = {2012-01-04T22:01:13.000Z},
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 last_modified = {2012-01-05T12:54:46.000Z},
 tags = {Bt corn,feed safety,food safety,human and animal health},
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 source_type = {Journal Article},
 abstract = {This study evaluated the gut and peripheral immune response to genetically modified (GM) maize in mice in vulnerable conditions. Weaning and old mice were fed a diet containing MON810 or its parental control maize or a pellet diet containing a GM-free maize for 30 and 90 days. The immunophenotype of intestinal intraepithelial, spleen, and blood lymphocytes of control maize fed mice was similar to that of pellet fed mice. As compared to control maize, MON810 maize induced alterations in the percentage of T and B cells and of CD4+, CD8+, γδT, and αβT subpopulations of weaning and old mice fed for 30 or 90 days, respectively, at the gut and peripheral sites. An increase of serum IL-6, IL-13, IL-12p70, and MIP-1β after MON810 feeding was also found. These results suggest the importance of the gut and peripheral immune response to GM crop ingestion as well as the age of the consumer in the GMO safety evaluation.},
 bibtype = {article},
 author = {Finamore, Alberto and Roselli, Marianna and Britti, Serena and Monastra, Giovanni and Ambra, Roberto and Turrini, Aida and Mengheri, Elena},
 journal = {Journal Of Agricultural And Food Chemistry},
 number = {23}
}
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