@article{
 title = {Meiotic drive reduces egg-to-adult viability in stalk-eyed flies},
 type = {article},
 year = {2019},
 identifiers = {[object Object]},
 keywords = {Meiotic drive,Selfish genetic element,Sex ratio,Sexual selection,Stalk-eyed fly,Teleopsis},
 volume = {286},
 id = {b2a9e285-55cf-38b0-9123-85e28870c3b8},
 created = {2019-09-11T23:59:00.000Z},
 file_attached = {false},
 profile_id = {546abfaf-1ae6-3bfb-801c-e676c4427313},
 last_modified = {2021-01-09T17:58:02.659Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {© 2019 The Author(s) Published by the Royal Society. All rights reserved. A number of species are affected by Sex-Ratio (SR) meiotic drive, a selfish genetic element located on the X-chromosome that causes dysfunction of Y-bearing sperm. SR is transmitted to up to 100% of offspring, causing extreme sex ratio bias. SR in several species is found in a stable polymorphism at a moderate frequency, suggesting there must be strong frequency-dependent selection resisting its spread. We investigate the effect of SR on female and male egg-to-adult viability in the Malaysian stalk-eyed fly, Teleopsis dalmanni. SR meiotic drive in this species is old, and appears to be broadly stable at a moderate (approx. 20%) frequency. We use large-scale controlled crosses to estimate the strength of selection acting against SR in female and male carriers. We find that SR reduces the egg-to-adult viability of both sexes. In females, homozygous females experience greater reduction in viability (sf = 0.242) and the deleterious effects of SR are additive (h = 0.511). The male deficit in viability (sm = 0.214) is not different from that in homozygous females. The evidence does not support the expectation that deleterious side effects of SR are recessive or sex-limited. We discuss how these reductions in egg-to-adult survival, as well as other forms of selection acting on SR, may maintain the SR polymorphism in this species.},
 bibtype = {article},
 author = {Finnegan, S.R. and White, N.J. and Koh, D. and Camus, M.F. and Fowler, K. and Pomiankowski, A.},
 journal = {Proceedings of the Royal Society B: Biological Sciences},
 number = {1910}
}

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A number of species are affected by Sex-Ratio (SR) meiotic drive, a selfish genetic element located on the X-chromosome that causes dysfunction of Y-bearing sperm. SR is transmitted to up to 100% of offspring, causing extreme sex ratio bias. SR in several species is found in a stable polymorphism at a moderate frequency, suggesting there must be strong frequency-dependent selection resisting its spread. We investigate the effect of SR on female and male egg-to-adult viability in the Malaysian stalk-eyed fly, Teleopsis dalmanni. SR meiotic drive in this species is old, and appears to be broadly stable at a moderate (approx. 20%) frequency. We use large-scale controlled crosses to estimate the strength of selection acting against SR in female and male carriers. We find that SR reduces the egg-to-adult viability of both sexes. In females, homozygous females experience greater reduction in viability (sf = 0.242) and the deleterious effects of SR are additive (h = 0.511). The male deficit in viability (sm = 0.214) is not different from that in homozygous females. The evidence does not support the expectation that deleterious side effects of SR are recessive or sex-limited. We discuss how these reductions in egg-to-adult survival, as well as other forms of selection acting on SR, may maintain the SR polymorphism in this species.","bibtype":"article","author":"Finnegan, S.R. and White, N.J. and Koh, D. and Camus, M.F. and Fowler, K. and Pomiankowski, A.","journal":"Proceedings of the Royal Society B: Biological Sciences","number":"1910","bibtex":"@article{\n title = {Meiotic drive reduces egg-to-adult viability in stalk-eyed flies},\n type = {article},\n year = {2019},\n identifiers = {[object Object]},\n keywords = {Meiotic drive,Selfish genetic element,Sex ratio,Sexual selection,Stalk-eyed fly,Teleopsis},\n volume = {286},\n id = {b2a9e285-55cf-38b0-9123-85e28870c3b8},\n created = {2019-09-11T23:59:00.000Z},\n file_attached = {false},\n profile_id = {546abfaf-1ae6-3bfb-801c-e676c4427313},\n last_modified = {2021-01-09T17:58:02.659Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {false},\n hidden = {false},\n private_publication = {false},\n abstract = {© 2019 The Author(s) Published by the Royal Society. All rights reserved. A number of species are affected by Sex-Ratio (SR) meiotic drive, a selfish genetic element located on the X-chromosome that causes dysfunction of Y-bearing sperm. SR is transmitted to up to 100% of offspring, causing extreme sex ratio bias. SR in several species is found in a stable polymorphism at a moderate frequency, suggesting there must be strong frequency-dependent selection resisting its spread. We investigate the effect of SR on female and male egg-to-adult viability in the Malaysian stalk-eyed fly, Teleopsis dalmanni. SR meiotic drive in this species is old, and appears to be broadly stable at a moderate (approx. 20%) frequency. We use large-scale controlled crosses to estimate the strength of selection acting against SR in female and male carriers. We find that SR reduces the egg-to-adult viability of both sexes. In females, homozygous females experience greater reduction in viability (sf = 0.242) and the deleterious effects of SR are additive (h = 0.511). The male deficit in viability (sm = 0.214) is not different from that in homozygous females. The evidence does not support the expectation that deleterious side effects of SR are recessive or sex-limited. We discuss how these reductions in egg-to-adult survival, as well as other forms of selection acting on SR, may maintain the SR polymorphism in this species.},\n bibtype = {article},\n author = {Finnegan, S.R. and White, N.J. and Koh, D. and Camus, M.F. and Fowler, K. and Pomiankowski, A.},\n journal = {Proceedings of the Royal Society B: Biological Sciences},\n number = {1910}\n}","author_short":["Finnegan, S.","White, N.","Koh, D.","Camus, M.","Fowler, K.","Pomiankowski, A."],"bibbaseid":"finnegan-white-koh-camus-fowler-pomiankowski-meioticdrivereduceseggtoadultviabilityinstalkeyedflies-2019","role":"author","urls":{},"keyword":["Meiotic drive","Selfish genetic element","Sex ratio","Sexual selection","Stalk-eyed fly","Teleopsis"],"downloads":0},"bibtype":"article","creationDate":"2021-01-20T12:13:18.641Z","downloads":0,"keywords":["meiotic drive","selfish genetic element","sex ratio","sexual selection","stalk-eyed fly","teleopsis"],"search_terms":["meiotic","drive","reduces","egg","adult","viability","stalk","eyed","flies","finnegan","white","koh","camus","fowler","pomiankowski"],"title":"Meiotic drive reduces egg-to-adult viability in stalk-eyed flies","year":2019}