Neurons from radial glia: the consequences of asymmetric inheritance. Fishell, G. & Kriegstein, A. R Curr Opin Neurobiol, 13(1):34–41, England, February, 2003.
abstract   bibtex   
Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster that have known mammalian homologs, Numb is the best candidate to have a similar function in radial glia. During asymmetric divisions of radial glial cells, the basal cell may inherit the radial glial fibre, while the apical cell sequesters the majority of the Numb protein. We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein.
@ARTICLE{Fishell2003-nr,
  title    = "Neurons from radial glia: the consequences of asymmetric
              inheritance",
  author   = "Fishell, Gord and Kriegstein, Arnold R",
  abstract = "Recent work suggests that radial glial cells represent many, if
              not most, of the neuronal progenitors in the developing cortex.
              Asymmetric cell division of radial glia results in the
              self-renewal of the radial glial cell and the birth of a neuron.
              Among the proteins that direct cell fate in Drosophila
              melanogaster that have known mammalian homologs, Numb is the best
              candidate to have a similar function in radial glia. During
              asymmetric divisions of radial glial cells, the basal cell may
              inherit the radial glial fibre, while the apical cell sequesters
              the majority of the Numb protein. We suggest two models that make
              opposite predictions as to whether the radial glia or nascent
              neuron inherit the radial glial fiber or the majority of the Numb
              protein.",
  journal  = "Curr Opin Neurobiol",
  volume   =  13,
  number   =  1,
  pages    = "34--41",
  month    =  feb,
  year     =  2003,
  address  = "England",
  language = "en"
}

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