@ARTICLE{Flint1999-ol,
  title    = "Endogenous activation of metabotropic glutamate receptors in
              neocortical development causes neuronal calcium oscillations",
  author   = "Flint, A C and Dammerman, R S and Kriegstein, A R",
  abstract = "Oscillations in intracellular free calcium concentration
              ([Ca(2+)](i)) occur spontaneously in immature neurons of the
              developing cerebral cortex. Here, we show that developing murine
              cortical neurons exhibit calcium oscillations in response to
              direct activation of the mGluR5 subtype of the group I
              metabotropic glutamate receptor (mGluR). In contrast, other
              manipulations that elicit [Ca(2+)](i) increases produce simple,
              nonoscillatory changes. Furthermore, we find that spontaneous
              oscillatory [Ca(2+)](i) activity is blocked by antagonists of
              group I mGluRs, suggesting a specific role for mGluR activation
              in the promotion of oscillatory [Ca(2+)](i) dynamics in immature
              cortical neurons. The oscillatory pattern of [Ca(2+)](i)
              increases produced by mGluR activation might play a role in the
              regulation of gene expression and the control of developmental
              events.",
  journal  = "Proc Natl Acad Sci U S A",
  volume   =  96,
  number   =  21,
  pages    = "12144--12149",
  month    =  oct,
  year     =  1999,
  language = "en"
}

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