@ARTICLE{Flint1998-np,
  title    = "Nonsynaptic glycine receptor activation during early neocortical
              development",
  author   = "Flint, A C and Liu, X and Kriegstein, A R",
  abstract = "Glycine receptors (GlyRs) contribute to fast inhibitory synaptic
              transmission in the brain stem and spinal cord. GlyR subunits are
              expressed in the developing neocortex, but a neurotransmitter
              system involving cortical GlyRs has yet to be demonstrated. Here,
              we show that GlyRs in immature neocortex are excitatory and
              activated by a nonsynaptically released endogenous ligand. Of the
              potential ligands for cortical GlyRs, taurine is by far the most
              abundant in the developing neocortex. We found that taurine is
              stored in immature cortical neurons and that manipulations known
              to elevate extracellular taurine cause GlyR activation. These
              data indicate that nonsynaptically released taurine activates
              GlyRs during neocortical development. As fetal taurine
              deprivation can cause cortical dysgenesis, it is possible that
              taurine influences neocortical development by activating GlyRs.",
  journal  = "Neuron",
  volume   =  20,
  number   =  1,
  pages    = "43--53",
  month    =  jan,
  year     =  1998,
  address  = "United States",
  language = "en"
}

{"_id":"yKAfz6zwC2YEe9Cgc","bibbaseid":"flint-liu-kriegstein-nonsynapticglycinereceptoractivationduringearlyneocorticaldevelopment-1998","author_short":["Flint, A C","Liu, X","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"Nonsynaptic glycine receptor activation during early neocortical development","author":[{"propositions":[],"lastnames":["Flint"],"firstnames":["A","C"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["X"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"Glycine receptors (GlyRs) contribute to fast inhibitory synaptic transmission in the brain stem and spinal cord. GlyR subunits are expressed in the developing neocortex, but a neurotransmitter system involving cortical GlyRs has yet to be demonstrated. Here, we show that GlyRs in immature neocortex are excitatory and activated by a nonsynaptically released endogenous ligand. Of the potential ligands for cortical GlyRs, taurine is by far the most abundant in the developing neocortex. We found that taurine is stored in immature cortical neurons and that manipulations known to elevate extracellular taurine cause GlyR activation. These data indicate that nonsynaptically released taurine activates GlyRs during neocortical development. As fetal taurine deprivation can cause cortical dysgenesis, it is possible that taurine influences neocortical development by activating GlyRs.","journal":"Neuron","volume":"20","number":"1","pages":"43–53","month":"January","year":"1998","address":"United States","language":"en","bibtex":"@ARTICLE{Flint1998-np,\n title = \"Nonsynaptic glycine receptor activation during early neocortical\n development\",\n author = \"Flint, A C and Liu, X and Kriegstein, A R\",\n abstract = \"Glycine receptors (GlyRs) contribute to fast inhibitory synaptic\n transmission in the brain stem and spinal cord. GlyR subunits are\n expressed in the developing neocortex, but a neurotransmitter\n system involving cortical GlyRs has yet to be demonstrated. Here,\n we show that GlyRs in immature neocortex are excitatory and\n activated by a nonsynaptically released endogenous ligand. Of the\n potential ligands for cortical GlyRs, taurine is by far the most\n abundant in the developing neocortex. We found that taurine is\n stored in immature cortical neurons and that manipulations known\n to elevate extracellular taurine cause GlyR activation. These\n data indicate that nonsynaptically released taurine activates\n GlyRs during neocortical development. As fetal taurine\n deprivation can cause cortical dysgenesis, it is possible that\n taurine influences neocortical development by activating GlyRs.\",\n journal = \"Neuron\",\n volume = 20,\n number = 1,\n pages = \"43--53\",\n month = jan,\n year = 1998,\n address = \"United States\",\n language = \"en\"\n}\n\n","author_short":["Flint, A C","Liu, X","Kriegstein, A R"],"key":"Flint1998-np","id":"Flint1998-np","bibbaseid":"flint-liu-kriegstein-nonsynapticglycinereceptoractivationduringearlyneocorticaldevelopment-1998","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["nonsynaptic","glycine","receptor","activation","during","early","neocortical","development","flint","liu","kriegstein"],"title":"Nonsynaptic glycine receptor activation during early neocortical development","year":1998}