@ARTICLE{Felix2015-yx,
  title    = "Pervasive robustness in biological systems",
  author   = "F\'{e}lix, Marie-Anne and Barkoulas, Michalis",
  abstract = "Robustness is characterized by the invariant expression of a
              phenotype in the face of a genetic and/or environmental
              perturbation. Although phenotypic variance is a central measure
              in the mapping of the genotype and environment to the phenotype
              in quantitative evolutionary genetics, robustness is also a key
              feature in systems biology, resulting from nonlinearities in
              quantitative relationships between upstream and downstream
              components. In this Review, we provide a synthesis of these two
              lines of investigation, converging on understanding how variation
              propagates across biological systems. We critically assess the
              recent proliferation of studies identifying robustness-conferring
              genes in the context of the nonlinearity in biological systems.",
  journal  = "Nat. Rev. Genet.",
  volume   =  16,
  number   =  8,
  pages    = "483--496",
  month    =  aug,
  year     =  2015,
  keywords = "cancer;evolution;review;zotero;Zotero Import (Aug 30);Zotero
              Import (Aug 30)/My Library;Classics;Reviews/Evolution",
  language = "en",
  issn     = "1471-0056",
  doi      = "10.1038/nrg3949"
}

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