Does nebulized epinephrine improve the efficacy of hypertonic saline solution in the treatment of hospitalized moderate acute bronchiolitis? A double blind, randomized clinical trial. Flores-Gonzalez, J. C., Dominguez-Coronel, M. T., Matamala Morillo, M. A., Aragon Ramirez, M., Garcia Ortega, R. M., Davila Corrales, F. J., Garcia Palacios, M. V., Perez Guerrero, J. J., Garcia Garcia, L., & Lechuga Sancho, A. M. Minerva pediatrica, 68(2):81--8, 2016. Flores-Gonzalez, Jose Carlos. Department of Pediatrics, Puerta del Mar University Hospital, Cadiz, Spain - carlosflogon@gmail.com.abstract bibtex BACKGROUND: Nebulized 3% hypertonic saline solution (HSS 3%) has proven to reduce hospital stay in infants with acute bronchiolitis, as compared with nebulized physiological saline solutions. There are no studies assessing the effectiveness of nebulized epinephrine in patients treated with HSS 3%. The aim of this study was to compare the length of stay (LOS) in hospitalized patients treated with HSS 3% with placebo vs. HSS 3% with epinephrine. Secondarily we aimed to assess the effectiveness and safety of both treatments., METHODS: We performed a prospective, randomized, double-blind, parallel-group study, including infants hospitalized for moderate acute bronchiolitis. Both groups received standard life support and were randomly treated with nebulized HSS 3% (7 mL) with either placebo 3 mL or epinephrine 3 mL. Nebulizations were initially administered every four hours and this interval was modified according to the patient's response., RESULTS: Sixty-four infants were included, 32 patients in each group. No statistically significant differences were found between the two groups (P=0.948) in length of stay, disease severity, SatO2, respiratory rate or heart rate. On the third day of hospitalization, severity and respiratory rate in the HSS 3%+E presented a non statistically significant trend to an earlier improvement, (P=0.063 and P=0.096 repectively). No adverse events occurred. Four patients (two from each group) required transfer to the pediatric intensive care unit., CONCLUSIONS: With a third of the final estimated sample, we find a trend to an earlier clinical recovery in the epinephrine group, even though no statistical significant differences in LOS were found. The study needs to be continued until the total sample is recruited.
@article{flores-gonzalez_does_2016,
title = {Does nebulized epinephrine improve the efficacy of hypertonic saline solution in the treatment of hospitalized moderate acute bronchiolitis? {A} double blind, randomized clinical trial.},
volume = {68},
issn = {1827-1715},
abstract = {BACKGROUND: Nebulized 3\% hypertonic saline solution (HSS 3\%) has proven to reduce hospital stay in infants with acute bronchiolitis, as compared with nebulized physiological saline solutions. There are no studies assessing the effectiveness of nebulized epinephrine in patients treated with HSS 3\%. The aim of this study was to compare the length of stay (LOS) in hospitalized patients treated with HSS 3\% with placebo vs. HSS 3\% with epinephrine. Secondarily we aimed to assess the effectiveness and safety of both treatments., METHODS: We performed a prospective, randomized, double-blind, parallel-group study, including infants hospitalized for moderate acute bronchiolitis. Both groups received standard life support and were randomly treated with nebulized HSS 3\% (7 mL) with either placebo 3 mL or epinephrine 3 mL. Nebulizations were initially administered every four hours and this interval was modified according to the patient's response., RESULTS: Sixty-four infants were included, 32 patients in each group. No statistically significant differences were found between the two groups (P=0.948) in length of stay, disease severity, SatO2, respiratory rate or heart rate. On the third day of hospitalization, severity and respiratory rate in the HSS 3\%+E presented a non statistically significant trend to an earlier improvement, (P=0.063 and P=0.096 repectively). No adverse events occurred. Four patients (two from each group) required transfer to the pediatric intensive care unit., CONCLUSIONS: With a third of the final estimated sample, we find a trend to an earlier clinical recovery in the epinephrine group, even though no statistical significant differences in LOS were found. The study needs to be continued until the total sample is recruited.},
number = {2},
journal = {Minerva pediatrica},
author = {Flores-Gonzalez, Jose Carlos and Dominguez-Coronel, Maria Teresa and Matamala Morillo, Miguel Angel and Aragon Ramirez, Miriam and Garcia Ortega, Rosa Maria and Davila Corrales, Francisco Javier and Garcia Palacios, Maria Victoria and Perez Guerrero, Juan Jesus and Garcia Garcia, Laura and Lechuga Sancho, Alfonso Maria},
year = {2016},
note = {Flores-Gonzalez, Jose Carlos. Department of Pediatrics, Puerta del Mar University Hospital, Cadiz, Spain - carlosflogon@gmail.com.},
keywords = {*Bronchiolitis/dt [Drug Therapy], *Bronchodilator Agents/ad [Administration \& Dosage], *Epinephrine/ad [Administration \& Dosage], *Saline Solution, Hypertonic/ad [Administration \& Dosage], Acute Disease, Bronchiolitis/pp [Physiopathology], Double-Blind Method, Humans, Infant, Newborn, Nebulizers and Vaporizers, Prospective Studies, female, hospitalization, infant, length of stay, male, severity of illness index, treatment outcome},
pages = {81--8}
}
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{"_id":"kexnLqk2CDLcDjC4K","bibbaseid":"floresgonzalez-dominguezcoronel-matamalamorillo-aragonramirez-garciaortega-davilacorrales-garciapalacios-perezguerrero-etal-doesnebulizedepinephrineimprovetheefficacyofhypertonicsalinesolutioninthetreatmentofhospitalizedmoderateacutebronchiolitisadoubleblindrandomizedclinicaltrial-2016","downloads":0,"creationDate":"2017-05-12T19:33:31.228Z","title":"Does nebulized epinephrine improve the efficacy of hypertonic saline solution in the treatment of hospitalized moderate acute bronchiolitis? A double blind, randomized clinical trial.","author_short":["Flores-Gonzalez, J. C.","Dominguez-Coronel, M. T.","Matamala Morillo, M. A.","Aragon Ramirez, M.","Garcia Ortega, R. M.","Davila Corrales, F. J.","Garcia Palacios, M. V.","Perez Guerrero, J. J.","Garcia Garcia, L.","Lechuga Sancho, A. M."],"year":2016,"bibtype":"article","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"article","type":"article","title":"Does nebulized epinephrine improve the efficacy of hypertonic saline solution in the treatment of hospitalized moderate acute bronchiolitis? A double blind, randomized clinical trial.","volume":"68","issn":"1827-1715","abstract":"BACKGROUND: Nebulized 3% hypertonic saline solution (HSS 3%) has proven to reduce hospital stay in infants with acute bronchiolitis, as compared with nebulized physiological saline solutions. There are no studies assessing the effectiveness of nebulized epinephrine in patients treated with HSS 3%. The aim of this study was to compare the length of stay (LOS) in hospitalized patients treated with HSS 3% with placebo vs. HSS 3% with epinephrine. Secondarily we aimed to assess the effectiveness and safety of both treatments., METHODS: We performed a prospective, randomized, double-blind, parallel-group study, including infants hospitalized for moderate acute bronchiolitis. Both groups received standard life support and were randomly treated with nebulized HSS 3% (7 mL) with either placebo 3 mL or epinephrine 3 mL. Nebulizations were initially administered every four hours and this interval was modified according to the patient's response., RESULTS: Sixty-four infants were included, 32 patients in each group. No statistically significant differences were found between the two groups (P=0.948) in length of stay, disease severity, SatO2, respiratory rate or heart rate. On the third day of hospitalization, severity and respiratory rate in the HSS 3%+E presented a non statistically significant trend to an earlier improvement, (P=0.063 and P=0.096 repectively). No adverse events occurred. Four patients (two from each group) required transfer to the pediatric intensive care unit., CONCLUSIONS: With a third of the final estimated sample, we find a trend to an earlier clinical recovery in the epinephrine group, even though no statistical significant differences in LOS were found. The study needs to be continued until the total sample is recruited.","number":"2","journal":"Minerva pediatrica","author":[{"propositions":[],"lastnames":["Flores-Gonzalez"],"firstnames":["Jose","Carlos"],"suffixes":[]},{"propositions":[],"lastnames":["Dominguez-Coronel"],"firstnames":["Maria","Teresa"],"suffixes":[]},{"propositions":[],"lastnames":["Matamala","Morillo"],"firstnames":["Miguel","Angel"],"suffixes":[]},{"propositions":[],"lastnames":["Aragon","Ramirez"],"firstnames":["Miriam"],"suffixes":[]},{"propositions":[],"lastnames":["Garcia","Ortega"],"firstnames":["Rosa","Maria"],"suffixes":[]},{"propositions":[],"lastnames":["Davila","Corrales"],"firstnames":["Francisco","Javier"],"suffixes":[]},{"propositions":[],"lastnames":["Garcia","Palacios"],"firstnames":["Maria","Victoria"],"suffixes":[]},{"propositions":[],"lastnames":["Perez","Guerrero"],"firstnames":["Juan","Jesus"],"suffixes":[]},{"propositions":[],"lastnames":["Garcia","Garcia"],"firstnames":["Laura"],"suffixes":[]},{"propositions":[],"lastnames":["Lechuga","Sancho"],"firstnames":["Alfonso","Maria"],"suffixes":[]}],"year":"2016","note":"Flores-Gonzalez, Jose Carlos. Department of Pediatrics, Puerta del Mar University Hospital, Cadiz, Spain - carlosflogon@gmail.com.","keywords":"*Bronchiolitis/dt [Drug Therapy], *Bronchodilator Agents/ad [Administration & Dosage], *Epinephrine/ad [Administration & Dosage], *Saline Solution, Hypertonic/ad [Administration & Dosage], Acute Disease, Bronchiolitis/pp [Physiopathology], Double-Blind Method, Humans, Infant, Newborn, Nebulizers and Vaporizers, Prospective Studies, female, hospitalization, infant, length of stay, male, severity of illness index, treatment outcome","pages":"81--8","bibtex":"@article{flores-gonzalez_does_2016,\n\ttitle = {Does nebulized epinephrine improve the efficacy of hypertonic saline solution in the treatment of hospitalized moderate acute bronchiolitis? {A} double blind, randomized clinical trial.},\n\tvolume = {68},\n\tissn = {1827-1715},\n\tabstract = {BACKGROUND: Nebulized 3\\% hypertonic saline solution (HSS 3\\%) has proven to reduce hospital stay in infants with acute bronchiolitis, as compared with nebulized physiological saline solutions. There are no studies assessing the effectiveness of nebulized epinephrine in patients treated with HSS 3\\%. The aim of this study was to compare the length of stay (LOS) in hospitalized patients treated with HSS 3\\% with placebo vs. HSS 3\\% with epinephrine. Secondarily we aimed to assess the effectiveness and safety of both treatments., METHODS: We performed a prospective, randomized, double-blind, parallel-group study, including infants hospitalized for moderate acute bronchiolitis. Both groups received standard life support and were randomly treated with nebulized HSS 3\\% (7 mL) with either placebo 3 mL or epinephrine 3 mL. Nebulizations were initially administered every four hours and this interval was modified according to the patient's response., RESULTS: Sixty-four infants were included, 32 patients in each group. No statistically significant differences were found between the two groups (P=0.948) in length of stay, disease severity, SatO2, respiratory rate or heart rate. On the third day of hospitalization, severity and respiratory rate in the HSS 3\\%+E presented a non statistically significant trend to an earlier improvement, (P=0.063 and P=0.096 repectively). No adverse events occurred. Four patients (two from each group) required transfer to the pediatric intensive care unit., CONCLUSIONS: With a third of the final estimated sample, we find a trend to an earlier clinical recovery in the epinephrine group, even though no statistical significant differences in LOS were found. The study needs to be continued until the total sample is recruited.},\n\tnumber = {2},\n\tjournal = {Minerva pediatrica},\n\tauthor = {Flores-Gonzalez, Jose Carlos and Dominguez-Coronel, Maria Teresa and Matamala Morillo, Miguel Angel and Aragon Ramirez, Miriam and Garcia Ortega, Rosa Maria and Davila Corrales, Francisco Javier and Garcia Palacios, Maria Victoria and Perez Guerrero, Juan Jesus and Garcia Garcia, Laura and Lechuga Sancho, Alfonso Maria},\n\tyear = {2016},\n\tnote = {Flores-Gonzalez, Jose Carlos. Department of Pediatrics, Puerta del Mar University Hospital, Cadiz, Spain - carlosflogon@gmail.com.},\n\tkeywords = {*Bronchiolitis/dt [Drug Therapy], *Bronchodilator Agents/ad [Administration \\& Dosage], *Epinephrine/ad [Administration \\& Dosage], *Saline Solution, Hypertonic/ad [Administration \\& Dosage], Acute Disease, Bronchiolitis/pp [Physiopathology], Double-Blind Method, Humans, Infant, Newborn, Nebulizers and Vaporizers, Prospective Studies, female, hospitalization, infant, length of stay, male, severity of illness index, treatment outcome},\n\tpages = {81--8}\n}\n\n","author_short":["Flores-Gonzalez, J. C.","Dominguez-Coronel, M. T.","Matamala Morillo, M. A.","Aragon Ramirez, M.","Garcia Ortega, R. M.","Davila Corrales, F. J.","Garcia Palacios, M. V.","Perez Guerrero, J. J.","Garcia Garcia, L.","Lechuga Sancho, A. 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