Arabidopsis Anaphase-Promoting Complexes: Multiple Activators and Wide Range of Substrates Might Keep APC Perpetually Busy. Fülöp, K., Tarayre, S., Kelemen, Z., Horváth, G., Kevei, Z., Nikovics, K., Bakó, L., Brown, S., Kondorosi, A., & Kondorosi, E. Cell Cycle, 4(8):4084–4092, August, 2005. ![Arabidopsis Anaphase-Promoting Complexes: Multiple Activators and Wide Range of Substrates Might Keep APC Perpetually Busy [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The anaphase-promoting complex (APC), a multisubunit E3 ubiquitin ligase, is anessential regulator of the cell cycle from metaphase until S phase in yeast and metazoans.APC mediates degradation of numerous cell cycle-related proteins, including mitoticcyclins and its activation and substrate-specificity are determined by two adaptor proteins,Cdc20 and Cdh1. Plants have multiple APC activators and the Cdh1-type proteins, inaddition, are represented by two subclasses, known as Ccs52A and Ccs52B. TheArabidopsis genome contains five cdc20 genes as well as ccs52A1, ccs52A2 and ccs52B. InSchizosaccharomyces pombe, expression of the three Atccs52 genes elicited distinctphenotypes supporting non-redundant function of the AtCcs52 proteins. Consistent withthese activities, the AtCcs52 proteins were able to bind both to the yeast and theArabidopsis APCs. In synchronized Arabidopsis cell cultures the cdc20 transcripts werepresent from early G2 until the M-phase exit, ccs52B from G2/M to M while ccs52A1 andccs52A2 were from late M until early G2, suggesting consecutive action of these APCactivators in the plant cell cycle. The AtCcs52 proteins interacted with different subsets ofmitotic cyclins, in accordance with their expression profiles, either in free- or CDK-boundforms. Expression of most APC subunits was constitutive, whereas cdc27a and cdc27b,corresponding to two forms of apc3, and ubc19 and ubc20 encoding E2-C type ubiquitinconjugatingenzymes displayed differences in their cell cycle regulation. These dataindicate the existence of numerous APCCdc20/Ccs52/Cdc27 forms in Arabidopsis, which inconjunction with different E2 enzymes might have distinct or complementary functions atdistinct stages of the cell cycle.
@article{fulop_arabidopsis_2005,
title = {Arabidopsis {Anaphase}-{Promoting} {Complexes}: {Multiple} {Activators} and {Wide} {Range} of {Substrates} {Might} {Keep} {APC} {Perpetually} {Busy}},
volume = {4},
issn = {1538-4101},
shorttitle = {Arabidopsis {Anaphase}-{Promoting} {Complexes}},
url = {https://doi.org/10.4161/cc.4.8.1856},
doi = {10.4161/cc.4.8.1856},
abstract = {The anaphase-promoting complex (APC), a multisubunit E3 ubiquitin ligase, is anessential regulator of the cell cycle from metaphase until S phase in yeast and metazoans.APC mediates degradation of numerous cell cycle-related proteins, including mitoticcyclins and its activation and substrate-specificity are determined by two adaptor proteins,Cdc20 and Cdh1. Plants have multiple APC activators and the Cdh1-type proteins, inaddition, are represented by two subclasses, known as Ccs52A and Ccs52B. TheArabidopsis genome contains five cdc20 genes as well as ccs52A1, ccs52A2 and ccs52B. InSchizosaccharomyces pombe, expression of the three Atccs52 genes elicited distinctphenotypes supporting non-redundant function of the AtCcs52 proteins. Consistent withthese activities, the AtCcs52 proteins were able to bind both to the yeast and theArabidopsis APCs. In synchronized Arabidopsis cell cultures the cdc20 transcripts werepresent from early G2 until the M-phase exit, ccs52B from G2/M to M while ccs52A1 andccs52A2 were from late M until early G2, suggesting consecutive action of these APCactivators in the plant cell cycle. The AtCcs52 proteins interacted with different subsets ofmitotic cyclins, in accordance with their expression profiles, either in free- or CDK-boundforms. Expression of most APC subunits was constitutive, whereas cdc27a and cdc27b,corresponding to two forms of apc3, and ubc19 and ubc20 encoding E2-C type ubiquitinconjugatingenzymes displayed differences in their cell cycle regulation. These dataindicate the existence of numerous APCCdc20/Ccs52/Cdc27 forms in Arabidopsis, which inconjunction with different E2 enzymes might have distinct or complementary functions atdistinct stages of the cell cycle.},
number = {8},
urldate = {2021-10-14},
journal = {Cell Cycle},
author = {Fülöp, Katalin and Tarayre, Sylvie and Kelemen, Zsolt and Horváth, Gábor and Kevei, Zoltán and Nikovics, Krisztina and Bakó, László and Brown, Spencer and Kondorosi, Adam and Kondorosi, Eva},
month = aug,
year = {2005},
pages = {4084--4092},
}
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Expression of most APC subunits was constitutive, whereas cdc27a and cdc27b,corresponding to two forms of apc3, and ubc19 and ubc20 encoding E2-C type ubiquitinconjugatingenzymes displayed differences in their cell cycle regulation. 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