Regulation of mTOR by phosphatidic acid?. Foster, D. A 67(1):1–4, 1, 2007. ![Regulation of mTOR by phosphatidic acid? [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Interest in the regulation of the mammalian target of rapamycin (mTOR) has increased substantially in recent years largely because of an apparent link between mTOR and survival signals in human cancer cells. Much has been learned about the regulation of mTOR in response to survival signals generated by phosphatidylinositol 3-kinase (PI3K). However, another mechanism for regulating mTOR has been proposed involving the generation of phosphatidic acid (PA). PA is the metabolic product of phospholipase D (PLD), whose activity is elevated in a large number of human cancers, and, like PI3K, has been implicated in the survival of human cancer cells. Although the regulation of mTOR by the PI3K signaling pathway is well established, a role for PLD and PA in regulating mTOR has been controversial. In this review, the evidence implicating PLD and PA in the regulation of mTOR is summarized, and the implications of this novel and potentially important mechanism for regulating mTOR are discussed.
@article{Foster-2007-ID8,
title = {Regulation of m{TOR} by phosphatidic acid?},
abstract = {Interest in the regulation of the mammalian target of rapamycin (m{TOR})
has increased substantially in recent years largely because of an apparent
link between m{TOR} and survival signals in human cancer cells. Much has
been learned about the regulation of m{TOR} in response to survival signals
generated by phosphatidylinositol 3-kinase ({PI}3K). However, another
mechanism for regulating m{TOR} has been proposed involving the generation
of phosphatidic acid ({PA}). {PA} is the metabolic product of phospholipase
D ({PLD}), whose activity is elevated in a large number of human cancers,
and, like {PI}3K, has been implicated in the survival of human cancer
cells. Although the regulation of m{TOR} by the {PI}3K signaling pathway is
well established, a role for {PLD} and {PA} in regulating m{TOR} has been
controversial. In this review, the evidence implicating {PLD} and {PA} in
the regulation of m{TOR} is summarized, and the implications of this novel
and potentially important mechanism for regulating m{TOR} are discussed.},
author = {Foster, David A},
volume = {67},
number = {1},
pages = {1--4},
year = {2007},
month = {1},
url = {http://www.pubmed.org/17210675},
pmid = {17210675},
doi = {10.1158/0008-5472.CAN-06-3016},
keywords = {Animals, Humans, Phosphatidic Acids, Phospholipase D, Protein Kinases,
{TOR} Serine-Threonine Kinases},
file = {FULLTEXT:pdfs/000/000/000000008.pdf:PDF}
}
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