@article{
 title = {Cortical thickness in obsessive-compulsive disorder: multisite mega-analysis of 780 brain scans from six centres},
 type = {article},
 year = {2017},
 identifiers = {[object Object]},
 keywords = {Adult,Cerebral Cortex,Female,Hippocampus,Humans,Magnetic Resonance Imaging,Male,Obsessive-Compulsive Disorder},
 pages = {67-74},
 volume = {210},
 websites = {http://files/932/Fouche et al. - 2017 - Cortical thickness in obsessive-compulsive disorde.pdf,http://www.ncbi.nlm.nih.gov/pubmed/27198485},
 id = {c510d902-ef6a-365c-a5bf-25a1bf64d079},
 created = {2020-09-17T09:27:49.841Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:49.841Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {BACKGROUND: There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive-compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness. AIMS: To investigate alterations in cortical thickness and subcortical volume in OCD. METHOD: In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. RESULTS: Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group × age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls. CONCLUSIONS: Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group × age interaction effects may be the result of altered neuroplasticity.},
 bibtype = {article},
 author = {Fouche, Jean-Paul and du Plessis, Stefan and Hattingh, Coenie and Roos, Annerine and Lochner, Christine and Soriano-Mas, Carles and Sato, Joao R and Nakamae, Takashi and Nishida, Seiji and Kwon, Jun Soo and Jung, Wi Hoon and Mataix-Cols, David and Hoexter, Marcelo Q and Alonso, Pino and Consortium, O C D Brain Imaging and de Wit, Stella J and Veltman, Dick J and Stein, Dan J and van den Heuvel, Odile A},
 journal = {The British Journal of Psychiatry: The Journal of Mental Science},
 number = {1}
}

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AIMS: To investigate alterations in cortical thickness and subcortical volume in OCD. METHOD: In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. RESULTS: Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group × age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls. CONCLUSIONS: Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group × age interaction effects may be the result of altered neuroplasticity.","bibtype":"article","author":"Fouche, Jean-Paul and du Plessis, Stefan and Hattingh, Coenie and Roos, Annerine and Lochner, Christine and Soriano-Mas, Carles and Sato, Joao R and Nakamae, Takashi and Nishida, Seiji and Kwon, Jun Soo and Jung, Wi Hoon and Mataix-Cols, David and Hoexter, Marcelo Q and Alonso, Pino and Consortium, O C D Brain Imaging and de Wit, Stella J and Veltman, Dick J and Stein, Dan J and van den Heuvel, Odile A","journal":"The British Journal of Psychiatry: The Journal of Mental Science","number":"1","bibtex":"@article{\n title = {Cortical thickness in obsessive-compulsive disorder: multisite mega-analysis of 780 brain scans from six centres},\n type = {article},\n year = {2017},\n identifiers = {[object Object]},\n keywords = {Adult,Cerebral Cortex,Female,Hippocampus,Humans,Magnetic Resonance Imaging,Male,Obsessive-Compulsive Disorder},\n pages = {67-74},\n volume = {210},\n websites = {http://files/932/Fouche et al. - 2017 - Cortical thickness in obsessive-compulsive disorde.pdf,http://www.ncbi.nlm.nih.gov/pubmed/27198485},\n id = {c510d902-ef6a-365c-a5bf-25a1bf64d079},\n created = {2020-09-17T09:27:49.841Z},\n file_attached = {false},\n profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},\n group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},\n last_modified = {2020-09-17T09:27:49.841Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n source_type = {JOUR},\n language = {eng},\n private_publication = {false},\n abstract = {BACKGROUND: There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive-compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness. AIMS: To investigate alterations in cortical thickness and subcortical volume in OCD. METHOD: In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. RESULTS: Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group × age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls. CONCLUSIONS: Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. 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