Triplex DNA structures. Frank-Kamenetskii, M D & Mirkin, S M Annual review of biochemistry, 64:65–95, January, 1995. tex.ids= frank-kamenetskiiTriplexDNAStructure, frank-kamenetskiiTriplexDNAStructures, frank-kamenetskiiTriplexDNAStructuresa![Triplex DNA structures. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex A DNA triplex is formed when pyrimidine or purine bases occupy the major groove of the DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs. Intermolecular triplexes are formed between triplex forming oligonucleotides (TFO) and target sequences on duplex DNA. Intramolecular triplexes are the major elements of H-DNAs, unusual DNA structures, which are formed in homopurine-homopyrimidine regions of supercoiled DNAs. TFOs are promising gene-drugs, which can be used in an anti-gene strategy, that attempt to modulate gene activity in vivo. Numerous chemical modifications of TFO are known. In peptide nucleic acid (PNA), the sugar-phosphate backbone is replaced with a protein-like backbone. PNAs form P-loops while interacting with duplex DNA forming triplex with one of DNA strands leaving the other strand displaced. Very unusual recombination or parallel triplexes, or R-DNA, have been assumed to form under RecA protein in the course of homologous recombination.
@article{frank-kamenetskii_triplex_1995,
title = {Triplex {DNA} structures.},
volume = {64},
issn = {0066-4154},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7574496},
doi = {10.1146/annurev.bi.64.070195.000433},
abstract = {A DNA triplex is formed when pyrimidine or purine bases occupy the major groove of the DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs. Intermolecular triplexes are formed between triplex forming oligonucleotides (TFO) and target sequences on duplex DNA. Intramolecular triplexes are the major elements of H-DNAs, unusual DNA structures, which are formed in homopurine-homopyrimidine regions of supercoiled DNAs. TFOs are promising gene-drugs, which can be used in an anti-gene strategy, that attempt to modulate gene activity in vivo. Numerous chemical modifications of TFO are known. In peptide nucleic acid (PNA), the sugar-phosphate backbone is replaced with a protein-like backbone. PNAs form P-loops while interacting with duplex DNA forming triplex with one of DNA strands leaving the other strand displaced. Very unusual recombination or parallel triplexes, or R-DNA, have been assumed to form under RecA protein in the course of homologous recombination.},
journal = {Annual review of biochemistry},
author = {Frank-Kamenetskii, M D and Mirkin, S M},
month = jan,
year = {1995},
pmid = {7574496},
note = {tex.ids= frank-kamenetskiiTriplexDNAStructure, frank-kamenetskiiTriplexDNAStructures, frank-kamenetskiiTriplexDNAStructuresa},
keywords = {Animals, DNA, DNA: chemistry, DNA: genetics, Drug Stability, Genetic, Humans, Molecular Structure, Nucleic Acid Conformation, Nucleic Acids, Nucleic Acids: chemistry, Peptides, Peptides: chemistry, Recombination},
pages = {65--95},
}
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