Sex differences in the association between body mass index and total hip or knee joint replacement resulting from osteoarthritis. Franklin, J., Ingvarsson, T., Englund, M., & Lohmander, L. S. 68(4):536--540.
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OBJECTIVE: To examine the association between body mass index (BMI) and osteoarthritis (OA) leading to total hip (THR) or knee (TKR) joint replacement. METHODS: Case-control study design. All patients still living in Iceland who had had a THR or TKR resulting from OA before the end of 2002 were invited to participate. First-degree relatives of participating patients served as controls. A total of 1473 patients (872 women) and 1103 controls (599 women), all born between 1910 and 1939 and who had answered a questionnaire including questions about height and weight, were analysed. A randomly selected sample, representative of the Icelandic population, was used as a secondary control group. RESULTS: The OR, adjusted for age, occupation and presence of hand OA, for having a THR was 1.1 (95% CI 0.9 to 1.5) for overweight men and 1.7 (95% CI 1.0 to 2.9) for obese men. The OR for having a TKR was 1.7 (95% CI 1.1 to 2.6) for overweight men and 5.3 (95% CI 2.8 to 10.1) for obese men. The OR for having a THR was 1.0 (95% CI 0.8 to 1.3) for overweight women and 1.0 (95% CI 0.6 to 1.5) for obese women. The OR for having a TKR was 1.6 (95% CI 1.1 to 2.2) for overweight women and 4.0 (95% CI 2.6 to 6.1) for obese women. CONCLUSION: This study supports a positive association between high BMI and TKR in both sexes, but for THR the association with BMI seems to be weaker, and possibly negligible for women.
@article{franklin_sex_2009,
	title = {Sex differences in the association between body mass index and total hip or knee joint replacement resulting from osteoarthritis},
	volume = {68},
	issn = {1468-2060},
	doi = {10.1136/ard.2007.086868},
	abstract = {{OBJECTIVE}: To examine the association between body mass index ({BMI}) and osteoarthritis ({OA}) leading to total hip ({THR}) or knee ({TKR}) joint replacement.
{METHODS}: Case-control study design. All patients still living in Iceland who had had a {THR} or {TKR} resulting from {OA} before the end of 2002 were invited to participate. First-degree relatives of participating patients served as controls. A total of 1473 patients (872 women) and 1103 controls (599 women), all born between 1910 and 1939 and who had answered a questionnaire including questions about height and weight, were analysed. A randomly selected sample, representative of the Icelandic population, was used as a secondary control group.
{RESULTS}: The {OR}, adjusted for age, occupation and presence of hand {OA}, for having a {THR} was 1.1 (95\% {CI} 0.9 to 1.5) for overweight men and 1.7 (95\% {CI} 1.0 to 2.9) for obese men. The {OR} for having a {TKR} was 1.7 (95\% {CI} 1.1 to 2.6) for overweight men and 5.3 (95\% {CI} 2.8 to 10.1) for obese men. The {OR} for having a {THR} was 1.0 (95\% {CI} 0.8 to 1.3) for overweight women and 1.0 (95\% {CI} 0.6 to 1.5) for obese women. The {OR} for having a {TKR} was 1.6 (95\% {CI} 1.1 to 2.2) for overweight women and 4.0 (95\% {CI} 2.6 to 6.1) for obese women.
{CONCLUSION}: This study supports a positive association between high {BMI} and {TKR} in both sexes, but for {THR} the association with {BMI} seems to be weaker, and possibly negligible for women.},
	pages = {536--540},
	number = {4},
	journaltitle = {Annals of the Rheumatic Diseases},
	shortjournal = {Ann. Rheum. Dis.},
	author = {Franklin, J. and Ingvarsson, T. and Englund, M. and Lohmander, L. S.},
	date = {2009-04},
	pmid = {18504290},
	keywords = {Aged, 80 and over, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Body Mass Index, Case-Control Studies, Family, Female, Humans, Iceland, Male, Obesity, Occupational Diseases, Odds Ratio, Osteoarthritis, Hip, Osteoarthritis, Knee, Overweight, Regression Analysis, Risk Assessment, Sex Factors}
}

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