Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease. Franzmeier, N., Duering, M., Weiner, M., Dichgans, M., Ewers, M., & Alzheimer's Disease Neuroimaging, I. Neurology, 88(11):1054–1061, March, 2017. doi abstract bibtex OBJECTIVE: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory. METHODS: Forty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Abeta+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Abeta+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity x FDG-PET hypometabolism on episodic memory were tested. RESULTS: FDG-PET metabolism in the precuneus was reduced in MCI-Abeta+ compared to HC (p = 0.028), with stronger reductions observed in MCI-Abeta+ with more years of education (p = 0.006). In MCI-Abeta+, higher gLFC connectivity was associated with more years of education (p = 0.021). At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p = 0.027). CONCLUSIONS: Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.
@article{franzmeier_left_2017-1,
title = {Left frontal cortex connectivity underlies cognitive reserve in prodromal {Alzheimer} disease},
volume = {88},
issn = {1526-632X (Electronic) 0028-3878 (Linking)},
doi = {10.1212/WNL.0000000000003711},
abstract = {OBJECTIVE: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory. METHODS: Forty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Abeta+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Abeta+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity x FDG-PET hypometabolism on episodic memory were tested. RESULTS: FDG-PET metabolism in the precuneus was reduced in MCI-Abeta+ compared to HC (p = 0.028), with stronger reductions observed in MCI-Abeta+ with more years of education (p = 0.006). In MCI-Abeta+, higher gLFC connectivity was associated with more years of education (p = 0.021). At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p = 0.027). CONCLUSIONS: Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.},
number = {11},
journal = {Neurology},
author = {Franzmeier, N. and Duering, M. and Weiner, M. and Dichgans, M. and Ewers, M. and Alzheimer's Disease Neuroimaging, Initiative},
month = mar,
year = {2017},
pmcid = {PMC5384837},
pmid = {28188306},
keywords = {Female, Humans, Male, Magnetic Resonance Imaging, Nerve Net/*pathology, Oxygen/blood, Neuropsychological Tests, Cognition Disorders/*etiology, Functional Laterality, Functional Laterality/*physiology, Alzheimer Disease/*complications/diagnostic imaging/*pathology, Chi-Square Distribution, Cognitive Reserve/*physiology, Epilepsy/diagnostic imaging/etiology, Fluorodeoxyglucose F18/metabolism, Frontal Lobe/diagnostic imaging/pathology, Positron-Emission Tomography, Prodromal Symptoms, Fluorodeoxyglucose F18, Cognition Disorders, Alzheimer Disease, Epilepsy, Frontal Lobe, Nerve Net, Cognitive Reserve, Oxygen},
pages = {1054--1061},
}
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METHODS: Forty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Abeta+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Abeta+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity x FDG-PET hypometabolism on episodic memory were tested. RESULTS: FDG-PET metabolism in the precuneus was reduced in MCI-Abeta+ compared to HC (p = 0.028), with stronger reductions observed in MCI-Abeta+ with more years of education (p = 0.006). In MCI-Abeta+, higher gLFC connectivity was associated with more years of education (p = 0.021). At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p = 0.027). CONCLUSIONS: Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.","number":"11","journal":"Neurology","author":[{"propositions":[],"lastnames":["Franzmeier"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Duering"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Weiner"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Dichgans"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Ewers"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Alzheimer's","Disease","Neuroimaging"],"firstnames":["Initiative"],"suffixes":[]}],"month":"March","year":"2017","pmcid":"PMC5384837","pmid":"28188306","keywords":"Female, Humans, Male, Magnetic Resonance Imaging, Nerve Net/*pathology, Oxygen/blood, Neuropsychological Tests, Cognition Disorders/*etiology, Functional Laterality, Functional Laterality/*physiology, Alzheimer Disease/*complications/diagnostic imaging/*pathology, Chi-Square Distribution, Cognitive Reserve/*physiology, Epilepsy/diagnostic imaging/etiology, Fluorodeoxyglucose F18/metabolism, Frontal Lobe/diagnostic imaging/pathology, Positron-Emission Tomography, Prodromal Symptoms, Fluorodeoxyglucose F18, Cognition Disorders, Alzheimer Disease, Epilepsy, Frontal Lobe, Nerve Net, Cognitive Reserve, Oxygen","pages":"1054–1061","bibtex":"@article{franzmeier_left_2017-1,\n\ttitle = {Left frontal cortex connectivity underlies cognitive reserve in prodromal {Alzheimer} disease},\n\tvolume = {88},\n\tissn = {1526-632X (Electronic) 0028-3878 (Linking)},\n\tdoi = {10.1212/WNL.0000000000003711},\n\tabstract = {OBJECTIVE: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory. METHODS: Forty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Abeta+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Abeta+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity x FDG-PET hypometabolism on episodic memory were tested. RESULTS: FDG-PET metabolism in the precuneus was reduced in MCI-Abeta+ compared to HC (p = 0.028), with stronger reductions observed in MCI-Abeta+ with more years of education (p = 0.006). In MCI-Abeta+, higher gLFC connectivity was associated with more years of education (p = 0.021). At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p = 0.027). CONCLUSIONS: Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.},\n\tnumber = {11},\n\tjournal = {Neurology},\n\tauthor = {Franzmeier, N. and Duering, M. and Weiner, M. and Dichgans, M. and Ewers, M. and Alzheimer's Disease Neuroimaging, Initiative},\n\tmonth = mar,\n\tyear = {2017},\n\tpmcid = {PMC5384837},\n\tpmid = {28188306},\n\tkeywords = {Female, Humans, Male, Magnetic Resonance Imaging, Nerve Net/*pathology, Oxygen/blood, Neuropsychological Tests, Cognition Disorders/*etiology, Functional Laterality, Functional Laterality/*physiology, Alzheimer Disease/*complications/diagnostic imaging/*pathology, Chi-Square Distribution, Cognitive Reserve/*physiology, Epilepsy/diagnostic imaging/etiology, Fluorodeoxyglucose F18/metabolism, Frontal Lobe/diagnostic imaging/pathology, Positron-Emission Tomography, Prodromal Symptoms, Fluorodeoxyglucose F18, Cognition Disorders, Alzheimer Disease, Epilepsy, Frontal Lobe, Nerve Net, Cognitive Reserve, Oxygen},\n\tpages = {1054--1061},\n}\n\n","author_short":["Franzmeier, N.","Duering, M.","Weiner, M.","Dichgans, M.","Ewers, M.","Alzheimer's Disease Neuroimaging, I."],"key":"franzmeier_left_2017-1","id":"franzmeier_left_2017-1","bibbaseid":"franzmeier-duering-weiner-dichgans-ewers-alzheimersdiseaseneuroimaging-leftfrontalcortexconnectivityunderliescognitivereserveinprodromalalzheimerdisease-2017","role":"author","urls":{},"keyword":["Female","Humans","Male","Magnetic Resonance Imaging","Nerve Net/*pathology","Oxygen/blood","Neuropsychological Tests","Cognition Disorders/*etiology","Functional Laterality","Functional Laterality/*physiology","Alzheimer Disease/*complications/diagnostic imaging/*pathology","Chi-Square Distribution","Cognitive Reserve/*physiology","Epilepsy/diagnostic imaging/etiology","Fluorodeoxyglucose F18/metabolism","Frontal Lobe/diagnostic imaging/pathology","Positron-Emission Tomography","Prodromal Symptoms","Fluorodeoxyglucose F18","Cognition Disorders","Alzheimer Disease","Epilepsy","Frontal Lobe","Nerve Net","Cognitive Reserve","Oxygen"],"metadata":{"authorlinks":{}},"downloads":0},"bibtype":"article","biburl":"https://marcoduering.github.io/mduering.bib","creationDate":"2020-12-23T09:31:30.696Z","downloads":0,"keywords":["female","humans","male","magnetic resonance imaging","nerve net/*pathology","oxygen/blood","neuropsychological tests","cognition disorders/*etiology","functional laterality","functional laterality/*physiology","alzheimer disease/*complications/diagnostic imaging/*pathology","chi-square distribution","cognitive reserve/*physiology","epilepsy/diagnostic imaging/etiology","fluorodeoxyglucose f18/metabolism","frontal lobe/diagnostic imaging/pathology","positron-emission tomography","prodromal symptoms","fluorodeoxyglucose f18","cognition disorders","alzheimer disease","epilepsy","frontal lobe","nerve net","cognitive reserve","oxygen"],"search_terms":["left","frontal","cortex","connectivity","underlies","cognitive","reserve","prodromal","alzheimer","disease","franzmeier","duering","weiner","dichgans","ewers","alzheimer's disease neuroimaging"],"title":"Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease","year":2017,"dataSources":["uWMC5v24T7d5wGjeH"]}