Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment. Franzmeier, N., Gottler, J., Grimmer, T., Drzezga, A., Araque-Caballero, M. A., Simon-Vermot, L., Taylor, A. N. W., Burger, K., Catak, C., Janowitz, D., Muller, C., Duering, M., Sorg, C., & Ewers, M. Front Aging Neurosci, 9:264, 2017. doi abstract bibtex Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.
@article{franzmeier_resting-state_2017,
title = {Resting-{State} {Connectivity} of the {Left} {Frontal} {Cortex} to the {Default} {Mode} and {Dorsal} {Attention} {Network} {Supports} {Reserve} in {Mild} {Cognitive} {Impairment}},
volume = {9},
issn = {1663-4365 (Print) 1663-4365 (Linking)},
doi = {10.3389/fnagi.2017.00264},
abstract = {Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.},
journal = {Front Aging Neurosci},
author = {Franzmeier, N. and Gottler, J. and Grimmer, T. and Drzezga, A. and Araque-Caballero, M. A. and Simon-Vermot, L. and Taylor, A. N. W. and Burger, K. and Catak, C. and Janowitz, D. and Muller, C. and Duering, M. and Sorg, C. and Ewers, M.},
year = {2017},
pmcid = {PMC5545597},
pmid = {28824423},
keywords = {functional connectivity, cognitive reserve, frontoparietal control network, memory, mild cognitive impairment},
pages = {264},
}
Downloads: 0
{"_id":"TxdJdvGRbWnauHzPp","bibbaseid":"franzmeier-gottler-grimmer-drzezga-araquecaballero-simonvermot-taylor-burger-etal-restingstateconnectivityoftheleftfrontalcortextothedefaultmodeanddorsalattentionnetworksupportsreserveinmildcognitiveimpairment-2017","authorIDs":[],"author_short":["Franzmeier, N.","Gottler, J.","Grimmer, T.","Drzezga, A.","Araque-Caballero, M. A.","Simon-Vermot, L.","Taylor, A. N. W.","Burger, K.","Catak, C.","Janowitz, D.","Muller, C.","Duering, M.","Sorg, C.","Ewers, M."],"bibdata":{"bibtype":"article","type":"article","title":"Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment","volume":"9","issn":"1663-4365 (Print) 1663-4365 (Linking)","doi":"10.3389/fnagi.2017.00264","abstract":"Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.","journal":"Front Aging Neurosci","author":[{"propositions":[],"lastnames":["Franzmeier"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Gottler"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Grimmer"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Drzezga"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Araque-Caballero"],"firstnames":["M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Simon-Vermot"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Taylor"],"firstnames":["A.","N.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Burger"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Catak"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Janowitz"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Muller"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Duering"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Sorg"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Ewers"],"firstnames":["M."],"suffixes":[]}],"year":"2017","pmcid":"PMC5545597","pmid":"28824423","keywords":"functional connectivity, cognitive reserve, frontoparietal control network, memory, mild cognitive impairment","pages":"264","bibtex":"@article{franzmeier_resting-state_2017,\n\ttitle = {Resting-{State} {Connectivity} of the {Left} {Frontal} {Cortex} to the {Default} {Mode} and {Dorsal} {Attention} {Network} {Supports} {Reserve} in {Mild} {Cognitive} {Impairment}},\n\tvolume = {9},\n\tissn = {1663-4365 (Print) 1663-4365 (Linking)},\n\tdoi = {10.3389/fnagi.2017.00264},\n\tabstract = {Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.},\n\tjournal = {Front Aging Neurosci},\n\tauthor = {Franzmeier, N. and Gottler, J. and Grimmer, T. and Drzezga, A. and Araque-Caballero, M. A. and Simon-Vermot, L. and Taylor, A. N. W. and Burger, K. and Catak, C. and Janowitz, D. and Muller, C. and Duering, M. and Sorg, C. and Ewers, M.},\n\tyear = {2017},\n\tpmcid = {PMC5545597},\n\tpmid = {28824423},\n\tkeywords = {functional connectivity, cognitive reserve, frontoparietal control network, memory, mild cognitive impairment},\n\tpages = {264},\n}\n\n","author_short":["Franzmeier, N.","Gottler, J.","Grimmer, T.","Drzezga, A.","Araque-Caballero, M. A.","Simon-Vermot, L.","Taylor, A. N. W.","Burger, K.","Catak, C.","Janowitz, D.","Muller, C.","Duering, M.","Sorg, C.","Ewers, M."],"key":"franzmeier_resting-state_2017","id":"franzmeier_resting-state_2017","bibbaseid":"franzmeier-gottler-grimmer-drzezga-araquecaballero-simonvermot-taylor-burger-etal-restingstateconnectivityoftheleftfrontalcortextothedefaultmodeanddorsalattentionnetworksupportsreserveinmildcognitiveimpairment-2017","role":"author","urls":{},"keyword":["functional connectivity","cognitive reserve","frontoparietal control network","memory","mild cognitive impairment"],"metadata":{"authorlinks":{}},"downloads":0},"bibtype":"article","biburl":"https://marcoduering.github.io/mduering.bib","creationDate":"2020-12-23T09:31:30.694Z","downloads":0,"keywords":["functional connectivity","cognitive reserve","frontoparietal control network","memory","mild cognitive impairment"],"search_terms":["resting","state","connectivity","left","frontal","cortex","default","mode","dorsal","attention","network","supports","reserve","mild","cognitive","impairment","franzmeier","gottler","grimmer","drzezga","araque-caballero","simon-vermot","taylor","burger","catak","janowitz","muller","duering","sorg","ewers"],"title":"Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment","year":2017,"dataSources":["uWMC5v24T7d5wGjeH"]}