Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment. Franzmeier, N., Gottler, J., Grimmer, T., Drzezga, A., Araque-Caballero, M. A., Simon-Vermot, L., Taylor, A. N. W., Burger, K., Catak, C., Janowitz, D., Muller, C., Duering, M., Sorg, C., & Ewers, M. Front Aging Neurosci, 9:264, 2017.
doi  abstract   bibtex   
Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.
@article{franzmeier_resting-state_2017,
	title = {Resting-{State} {Connectivity} of the {Left} {Frontal} {Cortex} to the {Default} {Mode} and {Dorsal} {Attention} {Network} {Supports} {Reserve} in {Mild} {Cognitive} {Impairment}},
	volume = {9},
	issn = {1663-4365 (Print) 1663-4365 (Linking)},
	doi = {10.3389/fnagi.2017.00264},
	abstract = {Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFC-connectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the fronto-parietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anti-correlation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFC-connectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI.},
	journal = {Front Aging Neurosci},
	author = {Franzmeier, N. and Gottler, J. and Grimmer, T. and Drzezga, A. and Araque-Caballero, M. A. and Simon-Vermot, L. and Taylor, A. N. W. and Burger, K. and Catak, C. and Janowitz, D. and Muller, C. and Duering, M. and Sorg, C. and Ewers, M.},
	year = {2017},
	pmcid = {PMC5545597},
	pmid = {28824423},
	keywords = {functional connectivity, cognitive reserve, frontoparietal control network, memory, mild cognitive impairment},
	pages = {264},
}

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