Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment. Franzmeier, N., Hartmann, J. C., Taylor, A. N. W., Araque Caballero, M. A., Simon-Vermot, L., Buerger, K., Kambeitz-Ilankovic, L. M., Ertl-Wagner, B., Mueller, C., Catak, C., Janowitz, D., Stahl, R., Dichgans, M., Duering, M., & Ewers, M. J Alzheimers Dis, 59(4):1381–1392, 2017.
doi  abstract   bibtex   
Reserve in aging and Alzheimer's disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors. Recent evidence suggests that higher resting-state functional connectivity within the frontoparietal control network, specifically the left frontal cortex (LFC) hub, contributes to higher reserve. Following up these previous resting-state fMRI findings, we probed memory-task related functional connectivity of the LFC hub as a neural substrate of reserve. In elderly controls (CN, n = 37) and patients with mild cognitive impairment (MCI, n = 17), we assessed global connectivity of the LFC hub during successful face-name association learning, using generalized psychophysiological interaction analyses. Reserve was quantified as residualized memory performance, accounted for gender and proxies of neurodegeneration (age, hippocampus atrophy, and APOE genotype). We found that greater education was associated with higher LFC-connectivity in both CN and MCI during successful memory. Furthermore, higher LFC-connectivity predicted higher residualized memory (i.e., reserve). These results suggest that higher LFC-connectivity contributes to reserve in both healthy and pathological aging.
@article{franzmeier_left_2017,
	title = {Left {Frontal} {Hub} {Connectivity} during {Memory} {Performance} {Supports} {Reserve} in {Aging} and {Mild} {Cognitive} {Impairment}},
	volume = {59},
	issn = {1875-8908 (Electronic) 1387-2877 (Linking)},
	doi = {10.3233/JAD-170360},
	abstract = {Reserve in aging and Alzheimer's disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors. Recent evidence suggests that higher resting-state functional connectivity within the frontoparietal control network, specifically the left frontal cortex (LFC) hub, contributes to higher reserve. Following up these previous resting-state fMRI findings, we probed memory-task related functional connectivity of the LFC hub as a neural substrate of reserve. In elderly controls (CN, n = 37) and patients with mild cognitive impairment (MCI, n = 17), we assessed global connectivity of the LFC hub during successful face-name association learning, using generalized psychophysiological interaction analyses. Reserve was quantified as residualized memory performance, accounted for gender and proxies of neurodegeneration (age, hippocampus atrophy, and APOE genotype). We found that greater education was associated with higher LFC-connectivity in both CN and MCI during successful memory. Furthermore, higher LFC-connectivity predicted higher residualized memory (i.e., reserve). These results suggest that higher LFC-connectivity contributes to reserve in both healthy and pathological aging.},
	number = {4},
	journal = {J Alzheimers Dis},
	author = {Franzmeier, N. and Hartmann, J. C. and Taylor, A. N. W. and Araque Caballero, M. A. and Simon-Vermot, L. and Buerger, K. and Kambeitz-Ilankovic, L. M. and Ertl-Wagner, B. and Mueller, C. and Catak, C. and Janowitz, D. and Stahl, R. and Dichgans, M. and Duering, M. and Ewers, M.},
	year = {2017},
	pmcid = {PMC5611800},
	pmid = {28731448},
	keywords = {Aged, Female, Humans, Image Processing, Computer-Assisted, Male, Aged, 80 and over, Magnetic Resonance Imaging, Neural Pathways/diagnostic imaging, Memory, Aging, functional connectivity, Aging/*pathology, Brain Mapping, Functional Laterality, Functional Laterality/*physiology, cognitive reserve, memory, mild cognitive impairment, Apolipoproteins E/genetics, Cognitive Dysfunction/diagnostic imaging/genetics/*pathology, education, Face, Frontal Lobe/diagnostic imaging/*pathology, Memory/*physiology, Names, Nerve Net/diagnostic imaging/*pathology, Pattern Recognition, Visual/physiology, Sex Factors, task-fMRI, Frontal Lobe, Cognitive Dysfunction, Neural Pathways, Nerve Net, Apolipoproteins E, Pattern Recognition, Visual},
	pages = {1381--1392},
}

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