The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Franzmeier, N., Ren, J., Damm, A., Monte-Rubio, G., Boada, M., Ruiz, A., Ramirez, A., Jessen, F., Duzel, E., Rodriguez Gomez, O., Benzinger, T., Goate, A., Karch, C. M., Fagan, A. M., McDade, E., Buerger, K., Levin, J., Duering, M., Dichgans, M., Suarez-Calvet, M., Haass, C., Gordon, B. A., Lim, Y. Y., Masters, C. L., Janowitz, D., Catak, C., Wolfsgruber, S., Wagner, M., Milz, E., Moreno-Grau, S., Teipel, S., Grothe, M. J., Kilimann, I., Rossor, M., Fox, N., Laske, C., Chhatwal, J., Falkai, P., Perneczky, R., Lee, J. H., Spottke, A., Boecker, H., Brosseron, F., Fliessbach, K., Heneka, M. T., Nestor, P., Peters, O., Fuentes, M., Menne, F., Priller, J., Spruth, E. J., Franke, C., Schneider, A., Westerteicher, C., Speck, O., Wiltfang, J., Bartels, C., Araque Caballero, M. A., Metzger, C., Bittner, D., Salloway, S., Danek, A., Hassenstab, J., Yakushev, I., Schofield, P. R., Morris, J. C., Bateman, R. J., & Ewers, M. Mol Psychiatry, 26(2):614–628, March, 2019. doi abstract bibtex In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Abeta) on neurodegeneration and cognitive decline, rendering BDNFVal66Met an important modulating factor of cognitive impairment in AD. However, the effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on resting-state fMRI assessed functional networks. In seed-based connectivity analysis of six major large-scale networks, we found a stronger decrease of hippocampus (seed) to medial-frontal connectivity in the BDNFVal66Met carriers compared to BDNFVal homozogytes. BDNFVal66Met was not associated with connectivity in any other networks. Next, we tested whether the finding of more pronounced decrease in hippocampal-medial-frontal connectivity in BDNFVal66Met could be also found in elderly subjects with sporadically occurring Abeta, including a group with subjective cognitive decline (N = 149, FACEHBI study) and a group ranging from preclinical to AD dementia (N = 114, DELCODE study). In both of these independently recruited groups, BDNFVal66Met was associated with a stronger effect of more abnormal Abeta-levels (assessed by biofluid-assay or amyloid-PET) on hippocampal-medial-frontal connectivity decreases, controlled for hippocampus volume and other confounds. Lower hippocampal-medial-frontal connectivity was associated with lower global cognitive performance in the DIAN and DELCODE studies. Together these results suggest that BDNFVal66Met is selectively associated with a higher vulnerability of hippocampus-frontal connectivity to primary AD pathology, resulting in greater AD-related cognitive impairment.
@article{franzmeier_bdnfval66met_2019,
title = {The {BDNFVal66Met} {SNP} modulates the association between beta-amyloid and hippocampal disconnection in {Alzheimer}'s disease},
volume = {26},
issn = {1476-5578 (Electronic) 1359-4184 (Linking)},
doi = {10.1038/s41380-019-0404-6},
abstract = {In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Abeta) on neurodegeneration and cognitive decline, rendering BDNFVal66Met an important modulating factor of cognitive impairment in AD. However, the effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on resting-state fMRI assessed functional networks. In seed-based connectivity analysis of six major large-scale networks, we found a stronger decrease of hippocampus (seed) to medial-frontal connectivity in the BDNFVal66Met carriers compared to BDNFVal homozogytes. BDNFVal66Met was not associated with connectivity in any other networks. Next, we tested whether the finding of more pronounced decrease in hippocampal-medial-frontal connectivity in BDNFVal66Met could be also found in elderly subjects with sporadically occurring Abeta, including a group with subjective cognitive decline (N = 149, FACEHBI study) and a group ranging from preclinical to AD dementia (N = 114, DELCODE study). In both of these independently recruited groups, BDNFVal66Met was associated with a stronger effect of more abnormal Abeta-levels (assessed by biofluid-assay or amyloid-PET) on hippocampal-medial-frontal connectivity decreases, controlled for hippocampus volume and other confounds. Lower hippocampal-medial-frontal connectivity was associated with lower global cognitive performance in the DIAN and DELCODE studies. Together these results suggest that BDNFVal66Met is selectively associated with a higher vulnerability of hippocampus-frontal connectivity to primary AD pathology, resulting in greater AD-related cognitive impairment.},
number = {2},
journal = {Mol Psychiatry},
author = {Franzmeier, N. and Ren, J. and Damm, A. and Monte-Rubio, G. and Boada, M. and Ruiz, A. and Ramirez, A. and Jessen, F. and Duzel, E. and Rodriguez Gomez, O. and Benzinger, T. and Goate, A. and Karch, C. M. and Fagan, A. M. and McDade, E. and Buerger, K. and Levin, J. and Duering, M. and Dichgans, M. and Suarez-Calvet, M. and Haass, C. and Gordon, B. A. and Lim, Y. Y. and Masters, C. L. and Janowitz, D. and Catak, C. and Wolfsgruber, S. and Wagner, M. and Milz, E. and Moreno-Grau, S. and Teipel, S. and Grothe, M. J. and Kilimann, I. and Rossor, M. and Fox, N. and Laske, C. and Chhatwal, J. and Falkai, P. and Perneczky, R. and Lee, J. H. and Spottke, A. and Boecker, H. and Brosseron, F. and Fliessbach, K. and Heneka, M. T. and Nestor, P. and Peters, O. and Fuentes, M. and Menne, F. and Priller, J. and Spruth, E. J. and Franke, C. and Schneider, A. and Westerteicher, C. and Speck, O. and Wiltfang, J. and Bartels, C. and Araque Caballero, M. A. and Metzger, C. and Bittner, D. and Salloway, S. and Danek, A. and Hassenstab, J. and Yakushev, I. and Schofield, P. R. and Morris, J. C. and Bateman, R. J. and Ewers, M.},
month = mar,
year = {2019},
pmcid = {PMC6754794},
pmid = {30899092},
keywords = {Aged, Humans, Magnetic Resonance Imaging, Hippocampus, Positron-Emission Tomography, Amyloid beta-Peptides, Brain, Alzheimer Disease, Cognitive Dysfunction, Polymorphism, Single Nucleotide, Brain-Derived Neurotrophic Factor},
pages = {614--628},
}
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However, the effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on resting-state fMRI assessed functional networks. In seed-based connectivity analysis of six major large-scale networks, we found a stronger decrease of hippocampus (seed) to medial-frontal connectivity in the BDNFVal66Met carriers compared to BDNFVal homozogytes. BDNFVal66Met was not associated with connectivity in any other networks. Next, we tested whether the finding of more pronounced decrease in hippocampal-medial-frontal connectivity in BDNFVal66Met could be also found in elderly subjects with sporadically occurring Abeta, including a group with subjective cognitive decline (N = 149, FACEHBI study) and a group ranging from preclinical to AD dementia (N = 114, DELCODE study). In both of these independently recruited groups, BDNFVal66Met was associated with a stronger effect of more abnormal Abeta-levels (assessed by biofluid-assay or amyloid-PET) on hippocampal-medial-frontal connectivity decreases, controlled for hippocampus volume and other confounds. Lower hippocampal-medial-frontal connectivity was associated with lower global cognitive performance in the DIAN and DELCODE studies. 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However, the effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on resting-state fMRI assessed functional networks. In seed-based connectivity analysis of six major large-scale networks, we found a stronger decrease of hippocampus (seed) to medial-frontal connectivity in the BDNFVal66Met carriers compared to BDNFVal homozogytes. BDNFVal66Met was not associated with connectivity in any other networks. Next, we tested whether the finding of more pronounced decrease in hippocampal-medial-frontal connectivity in BDNFVal66Met could be also found in elderly subjects with sporadically occurring Abeta, including a group with subjective cognitive decline (N = 149, FACEHBI study) and a group ranging from preclinical to AD dementia (N = 114, DELCODE study). In both of these independently recruited groups, BDNFVal66Met was associated with a stronger effect of more abnormal Abeta-levels (assessed by biofluid-assay or amyloid-PET) on hippocampal-medial-frontal connectivity decreases, controlled for hippocampus volume and other confounds. Lower hippocampal-medial-frontal connectivity was associated with lower global cognitive performance in the DIAN and DELCODE studies. Together these results suggest that BDNFVal66Met is selectively associated with a higher vulnerability of hippocampus-frontal connectivity to primary AD pathology, resulting in greater AD-related cognitive impairment.},\n\tnumber = {2},\n\tjournal = {Mol Psychiatry},\n\tauthor = {Franzmeier, N. and Ren, J. and Damm, A. and Monte-Rubio, G. and Boada, M. and Ruiz, A. and Ramirez, A. and Jessen, F. and Duzel, E. and Rodriguez Gomez, O. and Benzinger, T. and Goate, A. and Karch, C. M. and Fagan, A. 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