The Economics of Reproducibility in Preclinical Research. Freedman, L. P, Cockburn, I. M, & Simcoe, T. S PLOS Biology, 13(6):e1002165, June, 2015.
The Economics of Reproducibility in Preclinical Research [link]Paper  doi  abstract   bibtex   
This Perspective provides estimates of the rate of irreproducibility of preclinical research and its direct cost implications. It goes on to outline a framework for solutions and a plan for long-term improvements in reproducibility rates.
@article{freedman_economics_2015,
	title = {The {Economics} of {Reproducibility} in {Preclinical} {Research}},
	volume = {13},
	url = {http://dx.plos.org/10.1371/journal.pbio.1002165},
	doi = {10.1371/journal.pbio.1002165},
	abstract = {This Perspective provides estimates of the rate of irreproducibility of preclinical research and its direct cost implications. It goes on to outline a framework for solutions and a plan for long-term improvements in reproducibility rates.},
	language = {English},
	number = {6},
	journal = {PLOS Biology},
	author = {Freedman, Leonard P and Cockburn, Iain M and Simcoe, Timothy S},
	month = jun,
	year = {2015},
	pages = {e1002165},
}

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