White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed. Freeze, W. M., Jacobs, H. I. L., de Jong, J. J., Verheggen, I. C. M., Gronenschild, E., Palm, W. M., Hoff, E. I., Wardlaw, J. M., Jansen, J. F. A., Verhey, F. R., & Backes, W. H. Neurobiol Aging, 85:113-122, 2020. Freeze, Whitney M Jacobs, Heidi I L de Jong, Joost J Verheggen, Inge C M Gronenschild, Ed H B M Palm, Walter M Hoff, Erik I Wardlaw, Joanna M Jansen, Jacobus F A Verhey, Frans R Backes, Walter H eng MR/J006971/1/MRC_/Medical Research Council/United Kingdom 2019/11/14 06:00 Neurobiol Aging. 2020 Jan;85:113-122. doi: 10.1016/j.neurobiolaging.2019.09.017. Epub 2019 Sep 27.![White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Blood-brain barrier (BBB) leakage is considered an important underlying process in both cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The objective of this study was to examine associations between BBB leakage, cSVD, neurodegeneration, and cognitive performance across the spectrum from normal cognition to dementia. Leakage was measured with dynamic contrast-enhanced magnetic resonance imaging in 80 older participants (normal cognition, n = 32; mild cognitive impairment, n = 34; clinical AD-type dementia, n = 14). Associations between leakage and white matter hyperintensity (WMH) volume, hippocampal volume, and cognition (information processing speed and memory performance) were examined with multivariable linear regression and mediation analyses. Leakage within the gray and white matter was positively associated with WMH volume (gray matter, p = 0.03; white matter, p = 0.01). A negative association was found between white matter BBB leakage and information processing speed performance, which was mediated by WMH volume. Leakage was not associated with hippocampal volume. WMH pathology is suggested to form a link between leakage and decline of information processing speed in older individuals with and without cognitive impairment.
@article{RN229,
author = {Freeze, W. M. and Jacobs, H. I. L. and de Jong, J. J. and Verheggen, I. C. M. and Gronenschild, Ehbm and Palm, W. M. and Hoff, E. I. and Wardlaw, J. M. and Jansen, J. F. A. and Verhey, F. R. and Backes, W. H.},
title = {White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed},
journal = {Neurobiol Aging},
volume = {85},
pages = {113-122},
note = {Freeze, Whitney M
Jacobs, Heidi I L
de Jong, Joost J
Verheggen, Inge C M
Gronenschild, Ed H B M
Palm, Walter M
Hoff, Erik I
Wardlaw, Joanna M
Jansen, Jacobus F A
Verhey, Frans R
Backes, Walter H
eng
MR/J006971/1/MRC_/Medical Research Council/United Kingdom
2019/11/14 06:00
Neurobiol Aging. 2020 Jan;85:113-122. doi: 10.1016/j.neurobiolaging.2019.09.017. Epub 2019 Sep 27.},
abstract = {Blood-brain barrier (BBB) leakage is considered an important underlying process in both cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The objective of this study was to examine associations between BBB leakage, cSVD, neurodegeneration, and cognitive performance across the spectrum from normal cognition to dementia. Leakage was measured with dynamic contrast-enhanced magnetic resonance imaging in 80 older participants (normal cognition, n = 32; mild cognitive impairment, n = 34; clinical AD-type dementia, n = 14). Associations between leakage and white matter hyperintensity (WMH) volume, hippocampal volume, and cognition (information processing speed and memory performance) were examined with multivariable linear regression and mediation analyses. Leakage within the gray and white matter was positively associated with WMH volume (gray matter, p = 0.03; white matter, p = 0.01). A negative association was found between white matter BBB leakage and information processing speed performance, which was mediated by WMH volume. Leakage was not associated with hippocampal volume. WMH pathology is suggested to form a link between leakage and decline of information processing speed in older individuals with and without cognitive impairment.},
keywords = {Blood-brain barrier
Cognition
Hippocampus
Small vessel disease
White matter hyperintensities},
ISSN = {1558-1497 (Electronic)
0197-4580 (Linking)},
DOI = {10.1016/j.neurobiolaging.2019.09.017},
url = {http://www.ncbi.nlm.nih.gov/pubmed/31718926
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year = {2020},
type = {Journal Article}
}
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M. and Jacobs, H. I. L. and de Jong, J. J. and Verheggen, I. C. M. and Gronenschild, Ehbm and Palm, W. M. and Hoff, E. I. and Wardlaw, J. M. and Jansen, J. F. A. and Verhey, F. R. and Backes, W. H.},\n title = {White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed},\n journal = {Neurobiol Aging},\n volume = {85},\n pages = {113-122},\n note = {Freeze, Whitney M\nJacobs, Heidi I L\nde Jong, Joost J\nVerheggen, Inge C M\nGronenschild, Ed H B M\nPalm, Walter M\nHoff, Erik I\nWardlaw, Joanna M\nJansen, Jacobus F A\nVerhey, Frans R\nBackes, Walter H\neng\nMR/J006971/1/MRC_/Medical Research Council/United Kingdom\n2019/11/14 06:00\nNeurobiol Aging. 2020 Jan;85:113-122. doi: 10.1016/j.neurobiolaging.2019.09.017. Epub 2019 Sep 27.},\n abstract = {Blood-brain barrier (BBB) leakage is considered an important underlying process in both cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The objective of this study was to examine associations between BBB leakage, cSVD, neurodegeneration, and cognitive performance across the spectrum from normal cognition to dementia. Leakage was measured with dynamic contrast-enhanced magnetic resonance imaging in 80 older participants (normal cognition, n = 32; mild cognitive impairment, n = 34; clinical AD-type dementia, n = 14). Associations between leakage and white matter hyperintensity (WMH) volume, hippocampal volume, and cognition (information processing speed and memory performance) were examined with multivariable linear regression and mediation analyses. Leakage within the gray and white matter was positively associated with WMH volume (gray matter, p = 0.03; white matter, p = 0.01). A negative association was found between white matter BBB leakage and information processing speed performance, which was mediated by WMH volume. Leakage was not associated with hippocampal volume. WMH pathology is suggested to form a link between leakage and decline of information processing speed in older individuals with and without cognitive impairment.},\n keywords = {Blood-brain barrier\nCognition\nHippocampus\nSmall vessel disease\nWhite matter hyperintensities},\n ISSN = {1558-1497 (Electronic)\n0197-4580 (Linking)},\n DOI = {10.1016/j.neurobiolaging.2019.09.017},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/31718926\nhttps://pdf.sciencedirectassets.com/271067/1-s2.0-S0197458019X0010X/1-s2.0-S0197458019303380/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEF4aCXVzLWVhc3QtMSJHMEUCIQCQGLYSXBQtb7r4qT6xaeajHMEJn6X2iG8WZ7Vpu8u5MQIgPVGKdIA2FkySMN3tV5iDJKECZpsVyFFnn7STPy7Mk%2FEqtAMIdhADGgwwNTkwMDM1NDY4NjUiDK5vEFyvRtd%2BCavrzSqRA0OF63kv2fsAOKn5lzBazvQ1yL9IkjHlyfXQWjFcvdmRtRiBu4318K2zDokogx4CQbn47M3Gx5tppJhVnhcjAFGxCWXw3PR%2Fw2x2j1VtWVZWPU3fe0lLG7b%2B%2BHGfvaY1L3nAY5mkXF3iNP57UFlAGzhnaj8Nmj2tn5gxzUpRPW2TkNDqI52nJXOh0rP4KwLmtAva2ZfmbO4Z59vpXs%2FB%2FwbfzQaDVQOPcc1OVP29h4PTRKO%2ByHCa9d7W0L0muCaUSkRfN98ZqiYArm6Y605ncr9mDtmDkMlD0TeBMKJ1pg8fIuaApWJCWjwyjO6ZiA3ARle%2BH6EecnASzG1%2FzcedAFwraeiOvkQgcE3thOabOY4DkCa5kijGz31Q%2FW9wSFVZn3IapMwms%2F%2B6124gSXXCtXyNy8SlQrw4B45hM%2BJ88e%2BbepYiuhVc6mwX%2FTNxzqz3A%2Fr01%2Bgn24kL1ou0ee9zRv8xV00ilXIG4vg9%2F9375c%2FT93Bl2VHGftxcddm5zW7MeozVm7o6UDjb3ZS89k%2FMn4QOMKbw1vQFOusB%2FPvv5yV10dZJp4ib90%2BwrNvb6qC3RRTjIYzYDbgqNsem%2BNb3KYh1%2FYp3v8jGG%2BJCmScNCjIyBE2CG%2F2hMNSOxn1OoUlux6ii78X%2BAY7RkHW9mSj1rJnln2oEQkNScHxnNJ%2FNo3ax5qusrILKOw9tHvW9q5ADFKQOUVyoHOUAokB3KVJklHDHlhEFT0PK5Mhxz3Onkx5wpsK%2Fhbg4duEbmCOQN4xvyMGFvkNk9e%2FJuOpG571y6v3An%2FeO1jOyK%2FJXUE6dXWKv1W6P1KqxAAscnr%2Be3EI69v0GtTdE77h57Bs2NPw6z66AX%2FchtQ%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20200414T144421Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY2Z7GK7HT%2F20200414%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=6650a5a1e25cb66781e4dc396a5b1946a692de246947f606c85c2b133aa9c555&hash=32853b2fb515b3523c9f281606d91b391f05bc615dbbb9bbd4da70855fac47d3&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0197458019303380&tid=spdf-fce9abfa-2520-4d1f-822d-1f5f1e421a36&sid=011858f4477d9942d7581a16e4804d44a9c6gxrqb&type=client\nhttps://pdf.sciencedirectassets.com/271067/1-s2.0-S0197458019X0010X/1-s2.0-S0197458019303380/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEEgaCXVzLWVhc3QtMSJIMEYCIQDrzk9x2%2FIfdiGPzs7XAqQtB2LllorOR8lDyN%2BdjkDq6gIhAKIOkn0kD35obhZhAAxTXlKitYOUKcCL3SFuHIuh5M9oKr0DCKH%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEQAxoMMDU5MDAzNTQ2ODY1IgxwrAqPRWdfD%2Bm4AHsqkQMitxg75n6AuF8YpgXrWv8YNZvRaUdk9Bpm1fw1CN996%2Ff8f7hTqZb2PKG5i1d1p8OblWz%2FmsbX5D9rMkbUMPw2y1MxV6c9VUQmP01S%2F0NmuEOGXTvvzTe2FDB1ZDYWdz1yEsUt5klf9VqEAtuxsCsJQoaR7cjYRrnb2mHv4C8ztBEpvtC%2BO3xhRrHSIvP3KDtn8%2BM3zi%2FAIv%2BWkCb%2BH%2BxS3fR7h0Sn11eEZqwETXFwR%2FZKQKyZ2kB7D88KrN4dFeWCM0EiyRbGxL9%2Fo1uCZN0WcpmFnR6TlWsfoW0CqOnwi1W7gvWcCO3tQ5mPEdcIOubJdNAjcnvI5GDN5Xm9J1rQU3VVWf5i%2B3u2%2B13sYzDyTU8Z2vpiZIWpj%2FxwT%2Fu%2BV5OtHIfP7cw8SVI7sP2bikFl0hbtKVIMUyUWtprMP5NEo51IHlCQWvuR5mimq2NEsrhbeh7O6R0jidYmtzq%2FK2YKOQAxEk8QoEljQQZRAdXgM89%2Bm8Ruyvuad3aVsN%2BHyY4fcWk9ho4zqa3wX3oe%2FvMcJTDFlLP2BTrqAUXm88z7ngTnIM2XPxIHFd%2BDZh7PG5fKuBp4OWj8kDs6hFuZz%2FxuiiaIGmj54ssYOkiVSv6ur9JVjKM9wEBU05Brl9m0RqTrZKrqsZZs30v2j2xWScOlObq4rl2rpjqih9hWwOWuQmKC7Kwx5NbeJhWDOzpMF4sYgdxrWtsZcUIWvDBG5e8ylLu4tjFv16080qhkpS2a9W%2F4VjYkgnHY642iJD3tHe2SI7M7WshxpgoBU3BCJGVsDYiEh4QcImjTAiu%2F%2FGGQAfkbKN2bWVZMAxr5Qld3tuoQLbukjm4cNX80TauK7Ox1nxkunQ%3D%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20200526T085055Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYVO5QZMYV%2F20200526%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=adc7248706cd007499ce582858cd72eaed4dde7737447cb5178cf9b70c1a6652&hash=e9097e6d94c144a32681a4ae27d76de62969266c1a09e4716cdc108e5526601d&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0197458019303380&tid=spdf-d14d30fe-eedb-4ba4-b18e-a153ab75020e&sid=ca5593271e00b340115a01a43f6cad28f5a2gxrqb&type=client},\n year = {2020},\n type = {Journal Article}\n}\n\n","author_short":["Freeze, W. 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