@article{RN192,
   author = {Freeze, W. M. and Jacobs, H. I. and Gronenschild, E. H. and Jansen, J. F. and Burgmans, S. and Aalten, P. and Clerx, L. and Vos, S. J. and van Buchem, M. A. and Barkhof, F. and van der Flier, W. M. and Verbeek, M. M. and Rikkert, M. O. and Backes, W. H. and Verhey, F. R. and Le, A. R. N. project},
   title = {White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta},
   journal = {J Alzheimers Dis},
   volume = {55},
   number = {1},
   pages = {333-342},
   note = {Freeze, Whitney M
Jacobs, Heidi I L
Gronenschild, Ed H
Jansen, Jacobus F A
Burgmans, Saartje
Aalten, Pauline
Clerx, Lies
Vos, Stephanie J
van Buchem, Mark A
Barkhof, Frederik
van der Flier, Wiesje M
Verbeek, Marcel M
Rikkert, Marcel Olde
Backes, Walter H
Verhey, Frans R
eng
Research Support, Non-U.S. Gov't
Netherlands
2016/09/24 06:00
J Alzheimers Dis. 2017;55(1):333-342. doi: 10.3233/JAD-160474.},
   abstract = {Cerebral small vessel disease (cSVD) and amyloid-beta (Abeta) deposition often co-exist in (prodromal) dementia, and both types of pathology have been associated with neurodegeneration. We examined whether cSVD and Abeta have independent or interactive effects on hippocampal volume (HV) in a memory clinic population. We included 87 individuals with clinical diagnoses of Alzheimer's disease (AD) (n = 24), mild cognitive impairment (MCI) (n = 26), and subjective cognitive complaints (SCC) (n = 37). cSVD magnetic resonance imaging markers included white matter hyperintensity (WMH) volume, lacunar infarct presence, and microbleed presence. Abeta pathology was assessed as cerebrospinal fluid-derived Abeta1 - 42 levels and dichotomized into normal or abnormal, and HV was determined by manual volumetric measurements. A linear hierarchical regression approach was applied for the detection of additive or interaction effects between cSVD and Abeta on HV in the total participant group (n = 87) and in the non-demented group (including SCC and MCI individuals only, n = 63). The results revealed that abnormal Abeta and lacunar infarct presence were independently associated with lower HV in the non-demented individuals. Interestingly, Abeta and WMH pathology interacted in the non-demented individuals, such that WMH had a negative effect on HV in individuals with abnormal CSF Abeta42 levels, but not in individuals with normal CSF Abeta42 levels. These associations were not present when individuals with AD were included in the analyses. Our observations suggest that relatively early on in the disease process older individuals with abnormal Abeta levels are at an increased risk of accelerated disease progression when concomitant cSVD is present.},
   keywords = {Aged
Alzheimer Disease/cerebrospinal fluid/diagnostic imaging
Amyloid beta-Peptides/*cerebrospinal fluid
Biomarkers/cerebrospinal fluid
Cerebral Hemorrhage/diagnostic imaging
Cerebral Small Vessel Diseases/cerebrospinal fluid/*diagnostic imaging
Cognition
Cognitive Dysfunction/cerebrospinal fluid/diagnostic imaging
Cross-Sectional Studies
Female
Hippocampus/*diagnostic imaging
Humans
Linear Models
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Organ Size
Perception
White Matter/*diagnostic imaging
*Amyloid-beta
*cerebral small vessel disease
*dementia
*neurodegeneration},
   ISSN = {1875-8908 (Electronic)
1387-2877 (Linking)},
   DOI = {10.3233/JAD-160474},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27662299
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160474},
   year = {2017},
   type = {Journal Article}
}

{"_id":"9u88AKuM6KAHEoCxz","bibbaseid":"freeze-jacobs-gronenschild-jansen-burgmans-aalten-clerx-vos-etal-whitematterhyperintensitiespotentiatehippocampalvolumereductioninnondementedolderindividualswithabnormalamyloidbeta-2017","downloads":0,"creationDate":"2018-08-03T14:29:50.075Z","title":"White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta","author_short":["Freeze, W. M.","Jacobs, H. I.","Gronenschild, E. H.","Jansen, J. F.","Burgmans, S.","Aalten, P.","Clerx, L.","Vos, S. J.","van Buchem, M. A.","Barkhof, F.","van der Flier, W. M.","Verbeek, M. M.","Rikkert, M. O.","Backes, W. H.","Verhey, F. R.","Le, A. R. N. p."],"year":2017,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Freeze"],"firstnames":["W.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jacobs"],"firstnames":["H.","I."],"suffixes":[]},{"propositions":[],"lastnames":["Gronenschild"],"firstnames":["E.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Burgmans"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Aalten"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Clerx"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Vos"],"firstnames":["S.","J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Buchem"],"firstnames":["M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Barkhof"],"firstnames":["F."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Flier"],"firstnames":["W.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Verbeek"],"firstnames":["M.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Rikkert"],"firstnames":["M.","O."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Verhey"],"firstnames":["F.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Le"],"firstnames":["A.","R.","N.","project"],"suffixes":[]}],"title":"White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta","journal":"J Alzheimers Dis","volume":"55","number":"1","pages":"333-342","note":"Freeze, Whitney M Jacobs, Heidi I L Gronenschild, Ed H Jansen, Jacobus F A Burgmans, Saartje Aalten, Pauline Clerx, Lies Vos, Stephanie J van Buchem, Mark A Barkhof, Frederik van der Flier, Wiesje M Verbeek, Marcel M Rikkert, Marcel Olde Backes, Walter H Verhey, Frans R eng Research Support, Non-U.S. Gov't Netherlands 2016/09/24 06:00 J Alzheimers Dis. 2017;55(1):333-342. doi: 10.3233/JAD-160474.","abstract":"Cerebral small vessel disease (cSVD) and amyloid-beta (Abeta) deposition often co-exist in (prodromal) dementia, and both types of pathology have been associated with neurodegeneration. We examined whether cSVD and Abeta have independent or interactive effects on hippocampal volume (HV) in a memory clinic population. We included 87 individuals with clinical diagnoses of Alzheimer's disease (AD) (n = 24), mild cognitive impairment (MCI) (n = 26), and subjective cognitive complaints (SCC) (n = 37). cSVD magnetic resonance imaging markers included white matter hyperintensity (WMH) volume, lacunar infarct presence, and microbleed presence. Abeta pathology was assessed as cerebrospinal fluid-derived Abeta1 - 42 levels and dichotomized into normal or abnormal, and HV was determined by manual volumetric measurements. A linear hierarchical regression approach was applied for the detection of additive or interaction effects between cSVD and Abeta on HV in the total participant group (n = 87) and in the non-demented group (including SCC and MCI individuals only, n = 63). The results revealed that abnormal Abeta and lacunar infarct presence were independently associated with lower HV in the non-demented individuals. Interestingly, Abeta and WMH pathology interacted in the non-demented individuals, such that WMH had a negative effect on HV in individuals with abnormal CSF Abeta42 levels, but not in individuals with normal CSF Abeta42 levels. These associations were not present when individuals with AD were included in the analyses. Our observations suggest that relatively early on in the disease process older individuals with abnormal Abeta levels are at an increased risk of accelerated disease progression when concomitant cSVD is present.","keywords":"Aged Alzheimer Disease/cerebrospinal fluid/diagnostic imaging Amyloid beta-Peptides/*cerebrospinal fluid Biomarkers/cerebrospinal fluid Cerebral Hemorrhage/diagnostic imaging Cerebral Small Vessel Diseases/cerebrospinal fluid/*diagnostic imaging Cognition Cognitive Dysfunction/cerebrospinal fluid/diagnostic imaging Cross-Sectional Studies Female Hippocampus/*diagnostic imaging Humans Linear Models Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Organ Size Perception White Matter/*diagnostic imaging *Amyloid-beta *cerebral small vessel disease *dementia *neurodegeneration","issn":"1875-8908 (Electronic) 1387-2877 (Linking)","doi":"10.3233/JAD-160474","url":"http://www.ncbi.nlm.nih.gov/pubmed/27662299 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160474","year":"2017","bibtex":"@article{RN192,\n author = {Freeze, W. M. and Jacobs, H. I. and Gronenschild, E. H. and Jansen, J. F. and Burgmans, S. and Aalten, P. and Clerx, L. and Vos, S. J. and van Buchem, M. A. and Barkhof, F. and van der Flier, W. M. and Verbeek, M. M. and Rikkert, M. O. and Backes, W. H. and Verhey, F. R. and Le, A. R. N. project},\n title = {White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta},\n journal = {J Alzheimers Dis},\n volume = {55},\n number = {1},\n pages = {333-342},\n note = {Freeze, Whitney M\nJacobs, Heidi I L\nGronenschild, Ed H\nJansen, Jacobus F A\nBurgmans, Saartje\nAalten, Pauline\nClerx, Lies\nVos, Stephanie J\nvan Buchem, Mark A\nBarkhof, Frederik\nvan der Flier, Wiesje M\nVerbeek, Marcel M\nRikkert, Marcel Olde\nBackes, Walter H\nVerhey, Frans R\neng\nResearch Support, Non-U.S. Gov't\nNetherlands\n2016/09/24 06:00\nJ Alzheimers Dis. 2017;55(1):333-342. doi: 10.3233/JAD-160474.},\n abstract = {Cerebral small vessel disease (cSVD) and amyloid-beta (Abeta) deposition often co-exist in (prodromal) dementia, and both types of pathology have been associated with neurodegeneration. We examined whether cSVD and Abeta have independent or interactive effects on hippocampal volume (HV) in a memory clinic population. We included 87 individuals with clinical diagnoses of Alzheimer's disease (AD) (n = 24), mild cognitive impairment (MCI) (n = 26), and subjective cognitive complaints (SCC) (n = 37). cSVD magnetic resonance imaging markers included white matter hyperintensity (WMH) volume, lacunar infarct presence, and microbleed presence. Abeta pathology was assessed as cerebrospinal fluid-derived Abeta1 - 42 levels and dichotomized into normal or abnormal, and HV was determined by manual volumetric measurements. A linear hierarchical regression approach was applied for the detection of additive or interaction effects between cSVD and Abeta on HV in the total participant group (n = 87) and in the non-demented group (including SCC and MCI individuals only, n = 63). The results revealed that abnormal Abeta and lacunar infarct presence were independently associated with lower HV in the non-demented individuals. Interestingly, Abeta and WMH pathology interacted in the non-demented individuals, such that WMH had a negative effect on HV in individuals with abnormal CSF Abeta42 levels, but not in individuals with normal CSF Abeta42 levels. These associations were not present when individuals with AD were included in the analyses. Our observations suggest that relatively early on in the disease process older individuals with abnormal Abeta levels are at an increased risk of accelerated disease progression when concomitant cSVD is present.},\n keywords = {Aged\nAlzheimer Disease/cerebrospinal fluid/diagnostic imaging\nAmyloid beta-Peptides/*cerebrospinal fluid\nBiomarkers/cerebrospinal fluid\nCerebral Hemorrhage/diagnostic imaging\nCerebral Small Vessel Diseases/cerebrospinal fluid/*diagnostic imaging\nCognition\nCognitive Dysfunction/cerebrospinal fluid/diagnostic imaging\nCross-Sectional Studies\nFemale\nHippocampus/*diagnostic imaging\nHumans\nLinear Models\nMagnetic Resonance Imaging\nMale\nMiddle Aged\nNeuropsychological Tests\nOrgan Size\nPerception\nWhite Matter/*diagnostic imaging\n*Amyloid-beta\n*cerebral small vessel disease\n*dementia\n*neurodegeneration},\n ISSN = {1875-8908 (Electronic)\n1387-2877 (Linking)},\n DOI = {10.3233/JAD-160474},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/27662299\nhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad160474},\n year = {2017},\n type = {Journal Article}\n}\n\n","author_short":["Freeze, W. M.","Jacobs, H. I.","Gronenschild, E. H.","Jansen, J. F.","Burgmans, S.","Aalten, P.","Clerx, L.","Vos, S. J.","van Buchem, M. A.","Barkhof, F.","van der Flier, W. M.","Verbeek, M. M.","Rikkert, M. O.","Backes, W. H.","Verhey, F. R.","Le, A. R. N. p."],"key":"RN192","id":"RN192","bibbaseid":"freeze-jacobs-gronenschild-jansen-burgmans-aalten-clerx-vos-etal-whitematterhyperintensitiespotentiatehippocampalvolumereductioninnondementedolderindividualswithabnormalamyloidbeta-2017","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/27662299 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160474"},"keyword":["Aged Alzheimer Disease/cerebrospinal fluid/diagnostic imaging Amyloid beta-Peptides/*cerebrospinal fluid Biomarkers/cerebrospinal fluid Cerebral Hemorrhage/diagnostic imaging Cerebral Small Vessel Diseases/cerebrospinal fluid/*diagnostic imaging Cognition Cognitive Dysfunction/cerebrospinal fluid/diagnostic imaging Cross-Sectional Studies Female Hippocampus/*diagnostic imaging Humans Linear Models Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Organ Size Perception White Matter/*diagnostic imaging *Amyloid-beta *cerebral small vessel disease *dementia *neurodegeneration"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["white","matter","hyperintensities","potentiate","hippocampal","volume","reduction","non","demented","older","individuals","abnormal","amyloid","beta","freeze","jacobs","gronenschild","jansen","burgmans","aalten","clerx","vos","van buchem","barkhof","van der flier","verbeek","rikkert","backes","verhey","le"],"keywords":["aged alzheimer disease/cerebrospinal fluid/diagnostic imaging amyloid beta-peptides/*cerebrospinal fluid biomarkers/cerebrospinal fluid cerebral hemorrhage/diagnostic imaging cerebral small vessel diseases/cerebrospinal fluid/*diagnostic imaging cognition cognitive dysfunction/cerebrospinal fluid/diagnostic imaging cross-sectional studies female hippocampus/*diagnostic imaging humans linear models magnetic resonance imaging male middle aged neuropsychological tests organ size perception white matter/*diagnostic imaging *amyloid-beta *cerebral small vessel disease *dementia *neurodegeneration"],"authorIDs":["TEAWLnKpXtQE8hs6C"],"dataSources":["TCkfRWJAZvbLAZi29"]}