@article{RN193,
   author = {Freeze, W. M. and Schnerr, R. S. and Palm, W. M. and Jansen, J. F. and Jacobs, H. I. and Hoff, E. I. and Verhey, F. R. and Backes, W. H.},
   title = {Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease},
   journal = {AJNR Am J Neuroradiol},
   volume = {38},
   number = {9},
   pages = {1742-1747},
   note = {Freeze, W M
Schnerr, R S
Palm, W M
Jansen, J F
Jacobs, H I
Hoff, E I
Verhey, F R
Backes, W H
eng
2017/07/08 06:00
AJNR Am J Neuroradiol. 2017 Sep;38(9):1742-1747. doi: 10.3174/ajnr.A5273. Epub 2017 Jul 6.},
   abstract = {BACKGROUND AND PURPOSE: Breakdown of BBB integrity occurs in dementia and may lead to neurodegeneration and cognitive decline. We assessed whether extravasation of gadolinium chelate could be visualized on delayed postcontrast FLAIR images in older individuals with and without cognitive impairment. MATERIALS AND METHODS: Seventy-four individuals participated in this study (15 with Alzheimer disease, 33 with mild cognitive impairment, and 26 with normal cognition). We assessed the appearance of pericortical enhancement after contrast administration, MR imaging markers of cerebrovascular damage, and medial temporal lobe atrophy. Three participants who were positive for pericortical enhancement (1 with normal cognition and 2 with mild cognitive impairment) were followed up for approximately 2 years. In vitro experiments with a range of gadolinium concentrations served to elucidate the mechanisms underlying the postcontrast FLAIR signals. RESULTS: Postcontrast pericortical enhancement was observed in 21 participants (28%), including 6 individuals with Alzheimer disease (40%), 10 with mild cognitive impairment (30%), and 5 with normal cognition (19%). Pericortical enhancement was positively associated with age (P < .02) and ischemic stroke (P < .05), but not with cognitive status (P = .3). Foci with enhanced signal remained stable across time in all follow-up cases. The in vitro measurements confirmed that FLAIR imaging is highly sensitive for the detection of low gadolinium concentrations in CSF, but not in cerebral tissue. CONCLUSIONS: Postcontrast pericortical enhancement on FLAIR images occurs in older individuals with normal cognition, mild cognitive impairment, and dementia. It may represent chronic focal superficial BBB leakage. Future longitudinal studies are needed to determine its clinical significance.},
   keywords = {Aged
Aged, 80 and over
Aging/*pathology
Alzheimer Disease/*diagnostic imaging/pathology
Blood-Brain Barrier/pathology
Cognitive Dysfunction/*diagnostic imaging/pathology
Contrast Media
Female
Gadolinium DTPA
Humans
Longitudinal Studies
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Neuroimaging/*methods},
   ISSN = {1936-959X (Electronic)
0195-6108 (Linking)},
   DOI = {10.3174/ajnr.A5273},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/28684457
http://www.ajnr.org/content/ajnr/38/9/1742.full.pdf},
   year = {2017},
   type = {Journal Article}
}

{"_id":"AEGvfk4XbepLjkyqr","bibbaseid":"freeze-schnerr-palm-jansen-jacobs-hoff-verhey-backes-pericorticalenhancementondelayedpostgadoliniumfluidattenuatedinversionrecoveryimagesinnormalagingmildcognitiveimpairmentandalzheimerdisease-2017","downloads":0,"creationDate":"2017-09-02T16:45:18.654Z","title":"Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease","author_short":["Freeze, W. M.","Schnerr, R. S.","Palm, W. M.","Jansen, J. F.","Jacobs, H. I.","Hoff, E. I.","Verhey, F. R.","Backes, W. H."],"year":2017,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Freeze"],"firstnames":["W.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Schnerr"],"firstnames":["R.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Palm"],"firstnames":["W.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Jacobs"],"firstnames":["H.","I."],"suffixes":[]},{"propositions":[],"lastnames":["Hoff"],"firstnames":["E.","I."],"suffixes":[]},{"propositions":[],"lastnames":["Verhey"],"firstnames":["F.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease","journal":"AJNR Am J Neuroradiol","volume":"38","number":"9","pages":"1742-1747","note":"Freeze, W M Schnerr, R S Palm, W M Jansen, J F Jacobs, H I Hoff, E I Verhey, F R Backes, W H eng 2017/07/08 06:00 AJNR Am J Neuroradiol. 2017 Sep;38(9):1742-1747. doi: 10.3174/ajnr.A5273. Epub 2017 Jul 6.","abstract":"BACKGROUND AND PURPOSE: Breakdown of BBB integrity occurs in dementia and may lead to neurodegeneration and cognitive decline. We assessed whether extravasation of gadolinium chelate could be visualized on delayed postcontrast FLAIR images in older individuals with and without cognitive impairment. MATERIALS AND METHODS: Seventy-four individuals participated in this study (15 with Alzheimer disease, 33 with mild cognitive impairment, and 26 with normal cognition). We assessed the appearance of pericortical enhancement after contrast administration, MR imaging markers of cerebrovascular damage, and medial temporal lobe atrophy. Three participants who were positive for pericortical enhancement (1 with normal cognition and 2 with mild cognitive impairment) were followed up for approximately 2 years. In vitro experiments with a range of gadolinium concentrations served to elucidate the mechanisms underlying the postcontrast FLAIR signals. RESULTS: Postcontrast pericortical enhancement was observed in 21 participants (28%), including 6 individuals with Alzheimer disease (40%), 10 with mild cognitive impairment (30%), and 5 with normal cognition (19%). Pericortical enhancement was positively associated with age (P < .02) and ischemic stroke (P < .05), but not with cognitive status (P = .3). Foci with enhanced signal remained stable across time in all follow-up cases. The in vitro measurements confirmed that FLAIR imaging is highly sensitive for the detection of low gadolinium concentrations in CSF, but not in cerebral tissue. CONCLUSIONS: Postcontrast pericortical enhancement on FLAIR images occurs in older individuals with normal cognition, mild cognitive impairment, and dementia. It may represent chronic focal superficial BBB leakage. Future longitudinal studies are needed to determine its clinical significance.","keywords":"Aged Aged, 80 and over Aging/*pathology Alzheimer Disease/*diagnostic imaging/pathology Blood-Brain Barrier/pathology Cognitive Dysfunction/*diagnostic imaging/pathology Contrast Media Female Gadolinium DTPA Humans Longitudinal Studies Magnetic Resonance Imaging/*methods Male Middle Aged Neuroimaging/*methods","issn":"1936-959X (Electronic) 0195-6108 (Linking)","doi":"10.3174/ajnr.A5273","url":"http://www.ncbi.nlm.nih.gov/pubmed/28684457 http://www.ajnr.org/content/ajnr/38/9/1742.full.pdf","year":"2017","bibtex":"@article{RN193,\n author = {Freeze, W. M. and Schnerr, R. S. and Palm, W. M. and Jansen, J. F. and Jacobs, H. I. and Hoff, E. I. and Verhey, F. R. and Backes, W. H.},\n title = {Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease},\n journal = {AJNR Am J Neuroradiol},\n volume = {38},\n number = {9},\n pages = {1742-1747},\n note = {Freeze, W M\nSchnerr, R S\nPalm, W M\nJansen, J F\nJacobs, H I\nHoff, E I\nVerhey, F R\nBackes, W H\neng\n2017/07/08 06:00\nAJNR Am J Neuroradiol. 2017 Sep;38(9):1742-1747. doi: 10.3174/ajnr.A5273. Epub 2017 Jul 6.},\n abstract = {BACKGROUND AND PURPOSE: Breakdown of BBB integrity occurs in dementia and may lead to neurodegeneration and cognitive decline. We assessed whether extravasation of gadolinium chelate could be visualized on delayed postcontrast FLAIR images in older individuals with and without cognitive impairment. MATERIALS AND METHODS: Seventy-four individuals participated in this study (15 with Alzheimer disease, 33 with mild cognitive impairment, and 26 with normal cognition). We assessed the appearance of pericortical enhancement after contrast administration, MR imaging markers of cerebrovascular damage, and medial temporal lobe atrophy. Three participants who were positive for pericortical enhancement (1 with normal cognition and 2 with mild cognitive impairment) were followed up for approximately 2 years. In vitro experiments with a range of gadolinium concentrations served to elucidate the mechanisms underlying the postcontrast FLAIR signals. RESULTS: Postcontrast pericortical enhancement was observed in 21 participants (28%), including 6 individuals with Alzheimer disease (40%), 10 with mild cognitive impairment (30%), and 5 with normal cognition (19%). Pericortical enhancement was positively associated with age (P < .02) and ischemic stroke (P < .05), but not with cognitive status (P = .3). Foci with enhanced signal remained stable across time in all follow-up cases. The in vitro measurements confirmed that FLAIR imaging is highly sensitive for the detection of low gadolinium concentrations in CSF, but not in cerebral tissue. CONCLUSIONS: Postcontrast pericortical enhancement on FLAIR images occurs in older individuals with normal cognition, mild cognitive impairment, and dementia. It may represent chronic focal superficial BBB leakage. Future longitudinal studies are needed to determine its clinical significance.},\n keywords = {Aged\nAged, 80 and over\nAging/*pathology\nAlzheimer Disease/*diagnostic imaging/pathology\nBlood-Brain Barrier/pathology\nCognitive Dysfunction/*diagnostic imaging/pathology\nContrast Media\nFemale\nGadolinium DTPA\nHumans\nLongitudinal Studies\nMagnetic Resonance Imaging/*methods\nMale\nMiddle Aged\nNeuroimaging/*methods},\n ISSN = {1936-959X (Electronic)\n0195-6108 (Linking)},\n DOI = {10.3174/ajnr.A5273},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/28684457\nhttp://www.ajnr.org/content/ajnr/38/9/1742.full.pdf},\n year = {2017},\n type = {Journal Article}\n}\n\n","author_short":["Freeze, W. M.","Schnerr, R. S.","Palm, W. M.","Jansen, J. F.","Jacobs, H. I.","Hoff, E. I.","Verhey, F. R.","Backes, W. H."],"key":"RN193","id":"RN193","bibbaseid":"freeze-schnerr-palm-jansen-jacobs-hoff-verhey-backes-pericorticalenhancementondelayedpostgadoliniumfluidattenuatedinversionrecoveryimagesinnormalagingmildcognitiveimpairmentandalzheimerdisease-2017","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/28684457 http://www.ajnr.org/content/ajnr/38/9/1742.full.pdf"},"keyword":["Aged Aged","80 and over Aging/*pathology Alzheimer Disease/*diagnostic imaging/pathology Blood-Brain Barrier/pathology Cognitive Dysfunction/*diagnostic imaging/pathology Contrast Media Female Gadolinium DTPA Humans Longitudinal Studies Magnetic Resonance Imaging/*methods Male Middle Aged Neuroimaging/*methods"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["pericortical","enhancement","delayed","postgadolinium","fluid","attenuated","inversion","recovery","images","normal","aging","mild","cognitive","impairment","alzheimer","disease","freeze","schnerr","palm","jansen","jacobs","hoff","verhey","backes"],"keywords":["aged aged","80 and over aging/*pathology alzheimer disease/*diagnostic imaging/pathology blood-brain barrier/pathology cognitive dysfunction/*diagnostic imaging/pathology contrast media female gadolinium dtpa humans longitudinal studies magnetic resonance imaging/*methods male middle aged neuroimaging/*methods"],"authorIDs":["TEAWLnKpXtQE8hs6C"],"dataSources":["TCkfRWJAZvbLAZi29"]}