MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density. Freimann, Baptist, F., M�ller, S., Streitberger, K., Guo, J., Rot, S., Ghori, A., Vajkoczy, P., Reiter, R., Sack, I., & Braun, J.R. NMR in Biomedicine, Jun, 2013. ![MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The aim of this study was to investigate the influence of neuronal density on viscoelastic parameters of living brain tissue after ischemic infarction in the mouse using MR elastography (MRE). Transient middle cerebral artery occlusion (MCAO) in the left hemisphere was induced in 20 mice. In vivo 7-T MRE at a vibration frequency of 900 Hz was performed on days 3, 7, 14 and 28 (n?=?5 per group) after MCAO, followed by the analysis of histological markers, such as neuron counts (NeuN). MCAO led to a significant reduction in the storage modulus in the left hemisphere relative to contralateral values (p?=?0.03) without changes over time. A correlation between storage modulus and NeuN in both hemispheres was observed, with correlation coefficients of R?=?0.648 (p?=?0.002, left) and R?=?0.622 (p?=?0.003, right). The loss modulus was less sensitive to MCAO, but correlated with NeuN in the left hemisphere (R?=?0.764, p?=?0.0001). In agreement with the literature, these results suggest that the shear modulus in the brain is reduced after transient ischemic insult. Furthermore, our study provides evidence that the in vivo shear modulus of brain tissue correlates with neuronal density. In diagnostic applications, MRE may thus have diagnostic potential as a tool for image-based quantification of neurodegenerative processes. Copyright � 2013 John Wiley & Sons, Ltd.
@article{ Freimann2013,
author = {Freimann, Florian Baptist and M�ller, Susanne and Streitberger, Kaspar-Josche
and Guo, Jing and Rot, Sergej and Ghori, Adnan and Vajkoczy, Peter
and Reiter, Rolf and Sack, Ingolf and Braun, J�rgen},
title = {MR elastography in a murine stroke model reveals correlation of macroscopic
viscoelastic properties of the brain with neuronal density.},
journal = {NMR in Biomedicine},
year = {2013},
month = {Jun},
abstract = {The aim of this study was to investigate the influence of neuronal
density on viscoelastic parameters of living brain tissue after ischemic
infarction in the mouse using MR elastography (MRE). Transient middle
cerebral artery occlusion (MCAO) in the left hemisphere was induced
in 20 mice. In vivo 7-T MRE at a vibration frequency of 900 Hz was
performed on days 3, 7, 14 and 28 (n?=?5 per group) after MCAO, followed
by the analysis of histological markers, such as neuron counts (NeuN).
MCAO led to a significant reduction in the storage modulus in the
left hemisphere relative to contralateral values (p?=?0.03) without
changes over time. A correlation between storage modulus and NeuN
in both hemispheres was observed, with correlation coefficients of
R?=?0.648 (p?=?0.002, left) and R?=?0.622 (p?=?0.003, right). The
loss modulus was less sensitive to MCAO, but correlated with NeuN
in the left hemisphere (R?=?0.764, p?=?0.0001). In agreement with
the literature, these results suggest that the shear modulus in the
brain is reduced after transient ischemic insult. Furthermore, our
study provides evidence that the in vivo shear modulus of brain tissue
correlates with neuronal density. In diagnostic applications, MRE
may thus have diagnostic potential as a tool for image-based quantification
of neurodegenerative processes. Copyright � 2013 John Wiley & Sons,
Ltd.},
doi = {10.1002/nbm.2987},
institution = {Department of Neurosurgery, Charit� - Universit�tsmedizin Berlin,
Berlin, Germany.},
language = {eng},
medline-pst = {aheadofprint},
owner = {Heiko},
pmid = {23784982},
timestamp = {2013.07.26},
url = {http://dx.doi.org/10.1002/nbm.2987}
}
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[.2987]\" \n\t class=\"bibbase_icon\"\n\t style=\"width: 24px; height: 24px; border: 0px; vertical-align: text-top\" ><span class=\"bibbase_icon_text\">Paper</span></a> \n \n \n <a href=\"javascript:showBib('Freimann2013')\">\n <img src=\"http://www.bibbase.org/img/filetypes/bib.png\" \n\t alt=\"MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density. [bib]\" \n\t class=\"bibbase_icon\"\n\t style=\"width: 24px; height: 24px; border: 0px; vertical-align: text-top\"><span class=\"bibbase_icon_text\">Bibtex</span></a>\n \n \n\n \n \n \n \n \n\n \n <a class=\"bibbase_abstract_link\" href=\"javascript:showAbstract('Freimann2013')\">Abstract</a>\n \n \n</span>\n\n<!-- -->\n<!-- <div id=\"abstract_Freimann2013\"> -->\n<!-- The aim of this study was to investigate the influence of neuronal density on viscoelastic parameters of living brain tissue after ischemic infarction in the mouse using MR elastography (MRE). Transient middle cerebral artery occlusion (MCAO) in the left hemisphere was induced in 20 mice. In vivo 7-T MRE at a vibration frequency of 900 Hz was performed on days 3, 7, 14 and 28 (n?=?5 per group) after MCAO, followed by the analysis of histological markers, such as neuron counts (NeuN). MCAO led to a significant reduction in the storage modulus in the left hemisphere relative to contralateral values (p?=?0.03) without changes over time. A correlation between storage modulus and NeuN in both hemispheres was observed, with correlation coefficients of R?=?0.648 (p?=?0.002, left) and R?=?0.622 (p?=?0.003, right). The loss modulus was less sensitive to MCAO, but correlated with NeuN in the left hemisphere (R?=?0.764, p?=?0.0001). In agreement with the literature, these results suggest that the shear modulus in the brain is reduced after transient ischemic insult. Furthermore, our study provides evidence that the in vivo shear modulus of brain tissue correlates with neuronal density. In diagnostic applications, MRE may thus have diagnostic potential as a tool for image-based quantification of neurodegenerative processes. Copyright � 2013 John Wiley & Sons, Ltd. -->\n<!-- </div> -->\n<!-- -->\n\n</div>\n","downloads":0,"abstract":"The aim of this study was to investigate the influence of neuronal density on viscoelastic parameters of living brain tissue after ischemic infarction in the mouse using MR elastography (MRE). Transient middle cerebral artery occlusion (MCAO) in the left hemisphere was induced in 20 mice. In vivo 7-T MRE at a vibration frequency of 900 Hz was performed on days 3, 7, 14 and 28 (n?=?5 per group) after MCAO, followed by the analysis of histological markers, such as neuron counts (NeuN). MCAO led to a significant reduction in the storage modulus in the left hemisphere relative to contralateral values (p?=?0.03) without changes over time. A correlation between storage modulus and NeuN in both hemispheres was observed, with correlation coefficients of R?=?0.648 (p?=?0.002, left) and R?=?0.622 (p?=?0.003, right). The loss modulus was less sensitive to MCAO, but correlated with NeuN in the left hemisphere (R?=?0.764, p?=?0.0001). In agreement with the literature, these results suggest that the shear modulus in the brain is reduced after transient ischemic insult. Furthermore, our study provides evidence that the in vivo shear modulus of brain tissue correlates with neuronal density. In diagnostic applications, MRE may thus have diagnostic potential as a tool for image-based quantification of neurodegenerative processes. Copyright � 2013 John Wiley & Sons, Ltd.","author":["Freimann","Baptist, Florian","M�ller, Susanne","Streitberger, Kaspar-Josche","Guo, Jing","Rot, Sergej","Ghori, Adnan","Vajkoczy, Peter","Reiter, Rolf","Sack, Ingolf","Braun, J�rgen"],"author_short":["Freimann","Baptist, F.","M�ller, S.","Streitberger, K.","Guo, J.","Rot, S.","Ghori, A.","Vajkoczy, P.","Reiter, R.","Sack, I.","Braun, J.R."],"bibtex":"@article{ Freimann2013,\n author = {Freimann, Florian Baptist and M�ller, Susanne and Streitberger, Kaspar-Josche\r\n\tand Guo, Jing and Rot, Sergej and Ghori, Adnan and Vajkoczy, Peter\r\n\tand Reiter, Rolf and Sack, Ingolf and Braun, J�rgen},\n title = {MR elastography in a murine stroke model reveals correlation of macroscopic\r\n\tviscoelastic properties of the brain with neuronal density.},\n journal = {NMR in Biomedicine},\n year = {2013},\n month = {Jun},\n abstract = {The aim of this study was to investigate the influence of neuronal\r\n\tdensity on viscoelastic parameters of living brain tissue after ischemic\r\n\tinfarction in the mouse using MR elastography (MRE). Transient middle\r\n\tcerebral artery occlusion (MCAO) in the left hemisphere was induced\r\n\tin 20 mice. In vivo 7-T MRE at a vibration frequency of 900 Hz was\r\n\tperformed on days 3, 7, 14 and 28 (n?=?5 per group) after MCAO, followed\r\n\tby the analysis of histological markers, such as neuron counts (NeuN).\r\n\tMCAO led to a significant reduction in the storage modulus in the\r\n\tleft hemisphere relative to contralateral values (p?=?0.03) without\r\n\tchanges over time. A correlation between storage modulus and NeuN\r\n\tin both hemispheres was observed, with correlation coefficients of\r\n\tR?=?0.648 (p?=?0.002, left) and R?=?0.622 (p?=?0.003, right). The\r\n\tloss modulus was less sensitive to MCAO, but correlated with NeuN\r\n\tin the left hemisphere (R?=?0.764, p?=?0.0001). In agreement with\r\n\tthe literature, these results suggest that the shear modulus in the\r\n\tbrain is reduced after transient ischemic insult. Furthermore, our\r\n\tstudy provides evidence that the in vivo shear modulus of brain tissue\r\n\tcorrelates with neuronal density. In diagnostic applications, MRE\r\n\tmay thus have diagnostic potential as a tool for image-based quantification\r\n\tof neurodegenerative processes. Copyright � 2013 John Wiley & Sons,\r\n\tLtd.},\n doi = {10.1002/nbm.2987},\n institution = {Department of Neurosurgery, Charit� - Universit�tsmedizin Berlin,\r\n\tBerlin, Germany.},\n language = {eng},\n medline-pst = {aheadofprint},\n owner = {Heiko},\n pmid = {23784982},\n timestamp = {2013.07.26},\n url = {http://dx.doi.org/10.1002/nbm.2987}\n}","bibtype":"article","doi":"10.1002/nbm.2987","id":"Freimann2013","institution":"Department of Neurosurgery, Charit� - Universit�tsmedizin Berlin, Berlin, Germany.","journal":"NMR in Biomedicine","key":"Freimann2013","language":"eng","medline-pst":"aheadofprint","month":"Jun","owner":"Heiko","pmid":"23784982","timestamp":"2013.07.26","title":"MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density.","type":"article","url":"http://dx.doi.org/10.1002/nbm.2987","year":"2013","role":"author","urls":{"Paper":"http://dx.doi.org/10.1002/nbm.2987"},"bibbaseid":"freimann-baptist-mller-streitberger-guo-rot-ghori-vajkoczy-reiter-sack-braun-mrelastographyinamurinestrokemodelrevealscorrelationofmacroscopicviscoelasticpropertiesofthebrainwithneuronaldensity-2013"},"bibtype":"article","biburl":"http://home.arcor.de/teambushido/Literatur.bib","downloads":0,"title":"MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density.","year":2013,"dataSources":["z828pEjP7GR5ew7B7"]}