Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro. French, K. M., Maxwell, J. T., Bhutani, S., Ghosh-Choudhary, S., Fierro, M. J., Johnson, T. D., Christman, K. L., Taylor, W. R., & Davis, M. E. Stem cells international, 2016:8364382, 2016.
doi  abstract   bibtex   
Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease. This work aims to assess the influence of two distinct signaling moieties on CPCs: cyclic biaxial strain and extracellular matrix. We evaluate four endpoints for improving CPC therapy: paracrine signaling, proliferation, connexin43 expression, and alignment. Vascular endothelial growth factor A (about 900 pg/mL) was secreted by CPCs cultured on fibronectin and collagen I. The application of mechanical strain increased vascular endothelial growth factor A secretion
@article{french_fibronectin_2016-1,
	title = {Fibronectin and {Cyclic} {Strain} {Improve} {Cardiac} {Progenitor} {Cell} {Regenerative} {Potential} {In} {Vitro}.},
	volume = {2016},
	issn = {1687-966X},
	doi = {10.1155/2016/8364382},
	abstract = {Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling  cues present in the microenvironment change with development and disease. This work aims to assess the influence of two distinct signaling moieties on CPCs: cyclic biaxial strain and extracellular matrix. We evaluate four endpoints for improving CPC therapy: paracrine signaling, proliferation, connexin43 expression, and alignment. Vascular endothelial growth factor A (about 900 pg/mL) was secreted by CPCs cultured on fibronectin and collagen I. The application of mechanical strain increased vascular endothelial growth factor A secretion},
	language = {eng},
	journal = {Stem cells international},
	author = {French, Kristin M. and Maxwell, Joshua T. and Bhutani, Srishti and Ghosh-Choudhary, Shohini and Fierro, Marcos J. and Johnson, Todd D. and Christman, Karen L. and Taylor, W. Robert and Davis, Michael E.},
	year = {2016},
	pmid = {27610140},
	pmcid = {PMC5004015},
	pages = {8364382}
}

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