A different TIPE of immune homeostasis

A different TIPE of immune homeostasis. Freundt, E. C., Bidere, N., & Lenardo, M. J. Cell, 133(3):401–2, May, 2008.

Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.

@article{freundt_different_2008,
	title = {A different {TIPE} of immune homeostasis},
	volume = {133},
	issn = {1097-4172 (ELECTRONIC) 0092-8674 (LINKING)},
	shorttitle = {A different {TIPE} of immune homeostasis},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/18455981},
	abstract = {Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.},
	number = {3},
	journal = {Cell},
	author = {Freundt, E. C. and Bidere, N. and Lenardo, M. J.},
	month = may,
	year = {2008},
	keywords = {Animals Caspases/metabolism Cell Death *Homeostasis Humans *Immunity, Innate Intracellular Signaling Peptides and Proteins/chemistry/*immunology Mice Protein Structure, Tertiary Signal Transduction Toll-Like Receptors/immunology},
	pages = {401--2},
}

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