Diffusion-weighted magnetic resonance imaging of head and neck squamous cell carcinomas. Friedrich, K., Matzek, W., Gentzsch, S., Sulzbacher, I., Czerny, C., & Herneth, A. European Journal of Radiology, 2008.
abstract   bibtex   
Objective: To evaluate whether diffusion-weighted imaging (DWI) is a reliable technique to quantify microstructural differences between head and neck squamous cell carcinomas (SCC) and tumour-free soft tissue. Materials and methods: DWI was obtained from 20 patients with histologically proven, untreated head and neck SCC. DWI was acquired using a diffusion-weighted, navigated echo-planar imaging sequence with a maximum b-value of 800 s/mm2. For an objective assessment of image quality, the signal-to-noise ratio (SNR) was calculated. Microstructural differences between vital tumour tissue and tumour-free soft tissue were quantified by calculating the apparent-diffusion-coefficients (ADC) on a pixel by pixel method. Results: Echo-planar DWI provided good image quality in all patients (mean SNR 18.4). The mean ADC of SCC, (0.64 ± 0.28 × 10-3 mm2/s), was significantly (P < 0.0001) lower than that of the tumour-free soft tissue, (2.51 ± 0.82 × 10-3 mm2/s). Conclusion: DWI is a reliable diagnostic tool to quantify the microstructural differences between vital tumour tissue and tumour-free soft tissue in patients with head and neck SCC. © 2007 Elsevier Ireland Ltd. All rights reserved.
@article{
 title = {Diffusion-weighted magnetic resonance imaging of head and neck squamous cell carcinomas},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Diffusion-weighted imaging,Head and neck cancer,Magnetic resonance imaging,Squamous cell carcinoma},
 volume = {68},
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 created = {2017-04-06T18:59:17.169Z},
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 last_modified = {2017-04-06T18:59:17.169Z},
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 abstract = {Objective: To evaluate whether diffusion-weighted imaging (DWI) is a reliable technique to quantify microstructural differences between head and neck squamous cell carcinomas (SCC) and tumour-free soft tissue. Materials and methods: DWI was obtained from 20 patients with histologically proven, untreated head and neck SCC. DWI was acquired using a diffusion-weighted, navigated echo-planar imaging sequence with a maximum b-value of 800 s/mm2. For an objective assessment of image quality, the signal-to-noise ratio (SNR) was calculated. Microstructural differences between vital tumour tissue and tumour-free soft tissue were quantified by calculating the apparent-diffusion-coefficients (ADC) on a pixel by pixel method. Results: Echo-planar DWI provided good image quality in all patients (mean SNR 18.4). The mean ADC of SCC, (0.64 ± 0.28 × 10-3 mm2/s), was significantly (P < 0.0001) lower than that of the tumour-free soft tissue, (2.51 ± 0.82 × 10-3 mm2/s). Conclusion: DWI is a reliable diagnostic tool to quantify the microstructural differences between vital tumour tissue and tumour-free soft tissue in patients with head and neck SCC. © 2007 Elsevier Ireland Ltd. All rights reserved.},
 bibtype = {article},
 author = {Friedrich, K.M. and Matzek, W. and Gentzsch, S. and Sulzbacher, I. and Czerny, C. and Herneth, A.M.},
 journal = {European Journal of Radiology},
 number = {3}
}
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