Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B. Frost, S. D. W., Liu, Y., Pond, S. L. K., Chappey, C., Wrin, T., Petropoulos, C. J., Little, S. J., & Richman, D. D. Journal of Virology, 79(10):6523–6527, May, 2005.
doi  abstract   bibtex   
We analyzed neutralization sensitivity and genetic variation of transmitted subtype B human immunodeficiency virus type 1 (HIV-1) in eight recently infected men who have sex with men and the virus from the six subjects who infected them. In contrast to reports of heterosexual transmission of subtype C HIV-1, in which the transmitted virus appears to be more neutralization sensitive, we demonstrate that in our study population, relatively few phenotypic changes in neutralization sensitivity or genotypic changes in envelope occurred during transmission of subtype B HIV-1. We suggest that limited genetic variation within the infecting host reduces the likelihood of selective transmission of neutralization-sensitive HIV.
@article{frost_characterization_2005,
	title = {Characterization of human immunodeficiency virus type 1 ({HIV}-1) envelope variation and neutralizing antibody responses during transmission of {HIV}-1 subtype {B}},
	volume = {79},
	issn = {0022-538X},
	doi = {10.1128/JVI.79.10.6523-6527.2005},
	abstract = {We analyzed neutralization sensitivity and genetic variation of transmitted subtype B human immunodeficiency virus type 1 (HIV-1) in eight recently infected men who have sex with men and the virus from the six subjects who infected them. In contrast to reports of heterosexual transmission of subtype C HIV-1, in which the transmitted virus appears to be more neutralization sensitive, we demonstrate that in our study population, relatively few phenotypic changes in neutralization sensitivity or genotypic changes in envelope occurred during transmission of subtype B HIV-1. We suggest that limited genetic variation within the infecting host reduces the likelihood of selective transmission of neutralization-sensitive HIV.},
	language = {eng},
	number = {10},
	journal = {Journal of Virology},
	author = {Frost, Simon D. W. and Liu, Yang and Pond, Sergei L. Kosakovsky and Chappey, Colombe and Wrin, Terri and Petropoulos, Christos J. and Little, Susan J. and Richman, Douglas D.},
	month = may,
	year = {2005},
	pmid = {15858036},
	pmcid = {PMC1091710},
	keywords = {Acute Disease, Disease Transmission, Infectious, Genetic Variation, HIV Antibodies, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, Neutralization Tests, Viral Envelope Proteins},
	pages = {6523--6527}
}

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