Computational investigation of drug action on human-induced stem cell-derived cardiomyocytes. Frotscher, R., Koch, J., & Staat, M. Journal of Biomechanical Engineering, 137(7):071002, July, 2015. ZSCC: 0000014
Computational investigation of drug action on human-induced stem cell-derived cardiomyocytes [link]Paper  doi  abstract   bibtex   
We compare experimental and computational results for the actions of the cardioactive drugs Lidocaine, Verapamil, Veratridine and Bay K 8644 on a tissue monolayer consisting of mainly fibroblasts and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSc-CM). The choice of the computational models is justified and literature data is collected to model drug action as accurately as possible. The focus of this work is to evaluate the validity and capability of existing models for native human cells with respect to the simulation of pharmaceutical treatment of monolayers and hiPSc-CM. From the comparison of experimental and computational results we derive suggestions for model improvements which are intended to computationally support the interpretation of experimental results obtained for hiPSc-CM.
@article{frotscher_computational_2015,
	title = {Computational investigation of drug action on human-induced stem cell-derived cardiomyocytes},
	volume = {137},
	copyright = {All rights reserved},
	issn = {0148-0731},
	url = {http://biomechanical.asmedigitalcollection.asme.org/article.aspx?doi=10.1115/1.4030173 http://www.ncbi.nlm.nih.gov/pubmed/25807216},
	doi = {10.1115/1.4030173},
	abstract = {We compare experimental and computational results for the actions of the cardioactive drugs Lidocaine, Verapamil, Veratridine and Bay K 8644 on a tissue monolayer consisting of mainly fibroblasts and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSc-CM). The choice of the computational models is justified and literature data is collected to model drug action as accurately as possible. The focus of this work is to evaluate the validity and capability of existing models for native human cells with respect to the simulation of pharmaceutical treatment of monolayers and hiPSc-CM. From the comparison of experimental and computational results we derive suggestions for model improvements which are intended to computationally support the interpretation of experimental results obtained for hiPSc-CM.},
	number = {7},
	journal = {Journal of Biomechanical Engineering},
	author = {Frotscher, Ralf and Koch, Jan-Peter and Staat, Manfred},
	month = jul,
	year = {2015},
	pmid = {25807216},
	note = {ZSCC: 0000014 },
	pages = {071002},
}

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