Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation. Frydman, N., Prisant, N., Hesters, L., Frydman, R., Tachdjian, G., Cohen-Bacrie, P., & Fanchin, R. Fertil Steril, 89(1):92–7, 2008.
Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation [link]Paper  abstract   bibtex   
OBJECTIVE: Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy ovarian function. DESIGN: Prospective study. SETTING: Teaching hospital, France. PATIENT(S): All 117 women were \textless38 years old, who combined normal serum day-3 FSH and inhibin B levels with an adequate response to controlled ovarian hyperstimulation. INTERVENTION(S): The DNA fragmentation rate was determined in the raw sperm used for conventional IVF by flow cytometric terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay. Cycles were sorted into two groups according to whether DNA fragmentation exceeded (high fragmentation [HF], n = 52) or did not exceed (low fragmentation [LF], n = 65) the 50th percentile of values (35%). MAIN OUTCOME MEASURE(S): D2 embryo quality and implantation and ongoing pregnancy rates. RESULT(S): Patients' characteristics, raw semen parameters, fertilization rates, and embryology data were similar in HF and LF groups. Clinical (37.5% vs. 62.5%) and ongoing (23.5% vs. 57.8%) pregnancy rates per ET and implantation rates (24.5% vs. 42.4%) were lower in the HF group than in the LF group. CONCLUSION(S): High sperm DNA fragmentation spares fertilization and top embryo morphology rates but is associated with decreased IVF-ET outcome.
@article{frydman_adequate_2008,
	title = {Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm {DNA} fragmentation},
	volume = {89},
	issn = {1556-5653},
	shorttitle = {Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm {DNA} fragmentation},
	url = {http://dx.doi.org/10.1016/j.fertnstert.2007.02.022},
	abstract = {OBJECTIVE: Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy ovarian function. DESIGN: Prospective study. SETTING: Teaching hospital, France. PATIENT(S): All 117 women were {\textless}38 years old, who combined normal serum day-3 FSH and inhibin B levels with an adequate response to controlled ovarian hyperstimulation. INTERVENTION(S): The DNA fragmentation rate was determined in the raw sperm used for conventional IVF by flow cytometric terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay. Cycles were sorted into two groups according to whether DNA fragmentation exceeded (high fragmentation [HF], n = 52) or did not exceed (low fragmentation [LF], n = 65) the 50th percentile of values (35\%). MAIN OUTCOME MEASURE(S): D2 embryo quality and implantation and ongoing pregnancy rates. RESULT(S): Patients' characteristics, raw semen parameters, fertilization rates, and embryology data were similar in HF and LF groups. Clinical (37.5\% vs. 62.5\%) and ongoing (23.5\% vs. 57.8\%) pregnancy rates per ET and implantation rates (24.5\% vs. 42.4\%) were lower in the HF group than in the LF group. CONCLUSION(S): High sperm DNA fragmentation spares fertilization and top embryo morphology rates but is associated with decreased IVF-ET outcome.},
	number = {1},
	journal = {Fertil Steril},
	author = {Frydman, Nelly and Prisant, Nadia and Hesters, Laetitia and Frydman, René and Tachdjian, Gérard and Cohen-Bacrie, Paul and Fanchin, Rénato},
	year = {2008},
	pages = {92--7}
}
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