Attenuation of the neural response to sad faces in major depressionby antidepressant treatment: A prospective, event-related functional magnetic resonance imagingstudy. Fu CY, Williams SR, Cleare AJ, & et al Archives of General Psychiatry, 61(9):877--889, 2004. ![Attenuation of the neural response to sad faces in major depressionby antidepressant treatment: A prospective, event-related functional magnetic resonance imagingstudy [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Depression is associated with interpersonal difficulties related to abnormalities in affective facial processing.Objectives To map brain systems activated by sad facial affect processing in patients with depression and to identify brain functional correlates of antidepressant treatment and symptomatic response.Design Two groups underwent scanning twice using functional magnetic resonance imaging (fMRI) during an 8-week period. The event-related fMRI paradigm entailed incidental affect recognition of facial stimuli morphed to express discriminable intensities of sadness.Setting Participants were recruited by advertisement from the local population; depressed subjects were treated as outpatients.Patients and Other Participants We matched 19 medication-free, acutely symptomatic patients satisfying DSM-IVcriteria for unipolar major depressive disorder by age, sex, and IQ with 19 healthy volunteers.Intervention After the baseline assessment, patients received fluoxetine hydrochloride, 20 mg/d, for 8 weeks.Main Outcome Measures Average activation (capacity) and differential response to variable affective intensity (dynamic range) were estimated in each fMRI time series. We used analysis of variance to identify brain regions that demonstrated a main effect of group (depressed vs healthy subjects) and a group × time interaction (attributable to antidepressant treatment). Change in brain activation associated with reduction of depressive symptoms in the patient group was identified by means of regression analysis. Permutation tests were used for inference.Results Over time, depressed subjects showed reduced capacity for activation in the left amygdala, ventral striatum, and frontoparietal cortex and a negatively correlated increase of dynamic range in the prefrontal cortex. Symptomatic improvement was associated with reduction of dynamic range in the pregenual cingulate cortex, ventral striatum, and cerebellum.Conclusions Antidepressant treatment reduces left limbic, subcortical, and neocortical capacity for activation in depressed subjects and increases the dynamic range of the left prefrontal cortex. Changes in anterior cingulate function associated with symptomatic improvement indicate that fMRI may be a useful surrogate marker of antidepressant treatment response.
@article{fu_cy_attenuation_2004,
title = {Attenuation of the neural response to sad faces in major depressionby antidepressant treatment: {A} prospective, event-related functional magnetic resonance imagingstudy},
volume = {61},
issn = {0003-990X},
shorttitle = {Attenuation of the neural response to sad faces in major depressionby antidepressant treatment},
url = {http://dx.doi.org/10.1001/archpsyc.61.9.877},
doi = {10.1001/archpsyc.61.9.877},
abstract = {Background
Depression is associated with interpersonal difficulties related to
abnormalities in affective facial processing.Objectives
To map brain systems activated by sad facial affect processing in patients
with depression and to identify brain functional correlates of antidepressant
treatment and symptomatic response.Design
Two groups underwent scanning twice using functional magnetic resonance
imaging (fMRI) during an 8-week period. The event-related fMRI paradigm entailed
incidental affect recognition of facial stimuli morphed to express discriminable
intensities of sadness.Setting
Participants were recruited by advertisement from the local population;
depressed subjects were treated as outpatients.Patients and Other Participants
We matched 19 medication-free, acutely symptomatic patients satisfying DSM-IVcriteria for unipolar major depressive disorder
by age, sex, and IQ with 19 healthy volunteers.Intervention
After the baseline assessment, patients received fluoxetine hydrochloride,
20 mg/d, for 8 weeks.Main Outcome Measures
Average activation (capacity) and differential response to variable
affective intensity (dynamic range) were estimated in each fMRI time series.
We used analysis of variance to identify brain regions that demonstrated a
main effect of group (depressed vs healthy subjects) and a group × time
interaction (attributable to antidepressant treatment). Change in brain activation
associated with reduction of depressive symptoms in the patient group was
identified by means of regression analysis. Permutation tests were used for
inference.Results
Over time, depressed subjects showed reduced capacity for activation
in the left amygdala, ventral striatum, and frontoparietal cortex and a negatively
correlated increase of dynamic range in the prefrontal cortex. Symptomatic
improvement was associated with reduction of dynamic range in the pregenual
cingulate cortex, ventral striatum, and cerebellum.Conclusions
Antidepressant treatment reduces left limbic, subcortical, and neocortical
capacity for activation in depressed subjects and increases the dynamic range
of the left prefrontal cortex. Changes in anterior cingulate function associated
with symptomatic improvement indicate that fMRI may be a useful surrogate
marker of antidepressant treatment response.},
number = {9},
urldate = {2015-08-06TZ},
journal = {Archives of General Psychiatry},
author = {{Fu CY} and {Williams SR} and {Cleare AJ} and {et al}},
year = {2004},
pages = {877--889}
}
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The event-related fMRI paradigm entailed incidental affect recognition of facial stimuli morphed to express discriminable intensities of sadness.Setting Participants were recruited by advertisement from the local population; depressed subjects were treated as outpatients.Patients and Other Participants We matched 19 medication-free, acutely symptomatic patients satisfying DSM-IVcriteria for unipolar major depressive disorder by age, sex, and IQ with 19 healthy volunteers.Intervention After the baseline assessment, patients received fluoxetine hydrochloride, 20 mg/d, for 8 weeks.Main Outcome Measures Average activation (capacity) and differential response to variable affective intensity (dynamic range) were estimated in each fMRI time series. We used analysis of variance to identify brain regions that demonstrated a main effect of group (depressed vs healthy subjects) and a group × time interaction (attributable to antidepressant treatment). Change in brain activation associated with reduction of depressive symptoms in the patient group was identified by means of regression analysis. Permutation tests were used for inference.Results Over time, depressed subjects showed reduced capacity for activation in the left amygdala, ventral striatum, and frontoparietal cortex and a negatively correlated increase of dynamic range in the prefrontal cortex. Symptomatic improvement was associated with reduction of dynamic range in the pregenual cingulate cortex, ventral striatum, and cerebellum.Conclusions Antidepressant treatment reduces left limbic, subcortical, and neocortical capacity for activation in depressed subjects and increases the dynamic range of the left prefrontal cortex. Changes in anterior cingulate function associated with symptomatic improvement indicate that fMRI may be a useful surrogate marker of antidepressant treatment response.","number":"9","urldate":"2015-08-06TZ","journal":"Archives of General Psychiatry","author":[{"firstnames":[],"propositions":[],"lastnames":["Fu CY"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Williams SR"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Cleare AJ"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["et al"],"suffixes":[]}],"year":"2004","pages":"877--889","bibtex":"@article{fu_cy_attenuation_2004,\n\ttitle = {Attenuation of the neural response to sad faces in major depressionby antidepressant treatment: {A} prospective, event-related functional magnetic resonance imagingstudy},\n\tvolume = {61},\n\tissn = {0003-990X},\n\tshorttitle = {Attenuation of the neural response to sad faces in major depressionby antidepressant treatment},\n\turl = {http://dx.doi.org/10.1001/archpsyc.61.9.877},\n\tdoi = {10.1001/archpsyc.61.9.877},\n\tabstract = {Background \nDepression is associated with interpersonal difficulties related to\nabnormalities in affective facial processing.Objectives\nTo map brain systems activated by sad facial affect processing in patients\nwith depression and to identify brain functional correlates of antidepressant\ntreatment and symptomatic response.Design\nTwo groups underwent scanning twice using functional magnetic resonance\nimaging (fMRI) during an 8-week period. The event-related fMRI paradigm entailed\nincidental affect recognition of facial stimuli morphed to express discriminable\nintensities of sadness.Setting\nParticipants were recruited by advertisement from the local population;\ndepressed subjects were treated as outpatients.Patients and Other Participants\nWe matched 19 medication-free, acutely symptomatic patients satisfying DSM-IVcriteria for unipolar major depressive disorder\nby age, sex, and IQ with 19 healthy volunteers.Intervention\nAfter the baseline assessment, patients received fluoxetine hydrochloride,\n20 mg/d, for 8 weeks.Main Outcome Measures\nAverage activation (capacity) and differential response to variable\naffective intensity (dynamic range) were estimated in each fMRI time series.\nWe used analysis of variance to identify brain regions that demonstrated a\nmain effect of group (depressed vs healthy subjects) and a group × time\ninteraction (attributable to antidepressant treatment). Change in brain activation\nassociated with reduction of depressive symptoms in the patient group was\nidentified by means of regression analysis. Permutation tests were used for\ninference.Results\nOver time, depressed subjects showed reduced capacity for activation\nin the left amygdala, ventral striatum, and frontoparietal cortex and a negatively\ncorrelated increase of dynamic range in the prefrontal cortex. Symptomatic\nimprovement was associated with reduction of dynamic range in the pregenual\ncingulate cortex, ventral striatum, and cerebellum.Conclusions\nAntidepressant treatment reduces left limbic, subcortical, and neocortical\ncapacity for activation in depressed subjects and increases the dynamic range\nof the left prefrontal cortex. Changes in anterior cingulate function associated\nwith symptomatic improvement indicate that fMRI may be a useful surrogate\nmarker of antidepressant treatment response.},\n\tnumber = {9},\n\turldate = {2015-08-06TZ},\n\tjournal = {Archives of General Psychiatry},\n\tauthor = {{Fu CY} and {Williams SR} and {Cleare AJ} and {et al}},\n\tyear = {2004},\n\tpages = {877--889}\n}\n\n","author_short":["Fu CY","Williams SR","Cleare AJ","et al"],"key":"fu_cy_attenuation_2004","id":"fu_cy_attenuation_2004","bibbaseid":"fucy-williamssr-cleareaj-etal-attenuationoftheneuralresponsetosadfacesinmajordepressionbyantidepressanttreatmentaprospectiveeventrelatedfunctionalmagneticresonanceimagingstudy-2004","role":"author","urls":{"Paper":"http://dx.doi.org/10.1001/archpsyc.61.9.877"},"downloads":0},"search_terms":["attenuation","neural","response","sad","faces","major","depressionby","antidepressant","treatment","prospective","event","related","functional","magnetic","resonance","imagingstudy","fu cy","williams sr","cleare aj","et al"],"keywords":[],"authorIDs":[],"dataSources":["v98BPm7u4WMoReKPh"]}