Synthesis, characterization and antimicrobial studies on cis-platinum(II) complexes of 5-nitrosouracil derivatives. Gaballa, A. K. Spectrochimica Acta Part A, 75:146–151, 2010.
abstract   bibtex   
Two complexes were obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil (AMNU) and 6-methylamino-1-benzyl-5-nitrosouracil (MABNU) with cis-diaquadiamineplatinum(II) nitrate complex, cis-[Pt(NH3)2(H2O)2](NO3)2 . The complexes were isolated in good yields as powdery precipitates. They were characterized through their elemental analysis, infrared, UV–vis, and 1 H NMR spectroscopies as well as thermal analyses. The obtained results indicated that, pyrimidine bases substitute easily aqua ligands and interact with Pt(II) ions as a monodentate ligand in the neutral and ionic form for the ligands AMNU and MABNU, respectively. The exocyclic oxygen atoms are the most probable binding site. Square planar structures, cis-form, were proposed in both cases. The free ligands, and their Pt(II) complexes were screened for their antimicrobial activities.
@article{gaballa_synthesis_2010,
	title = {Synthesis, characterization and antimicrobial studies on cis-platinum({II}) complexes of 5-nitrosouracil derivatives},
	volume = {75},
	abstract = {Two complexes were obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil (AMNU) and 6-methylamino-1-benzyl-5-nitrosouracil (MABNU) with cis-diaquadiamineplatinum(II) nitrate complex, cis-[Pt(NH3)2(H2O)2](NO3)2 . The complexes were isolated in good yields as powdery precipitates. They were characterized through their elemental analysis, infrared, UV–vis, and 1 H NMR spectroscopies as well as thermal analyses. The obtained results indicated that, pyrimidine bases substitute easily aqua ligands and interact with Pt(II) ions as a monodentate ligand in the neutral and ionic form for the ligands AMNU and MABNU, respectively. The exocyclic oxygen atoms are the most probable binding site. Square planar structures, cis-form, were proposed in both cases. The free ligands, and their Pt(II) complexes were screened for their antimicrobial activities.},
	journal = {Spectrochimica Acta Part A},
	author = {Gaballa, A. K.},
	year = {2010},
	pages = {146--151},
}

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