Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology. Gadad, B. S., Li, W., Yazdani, U., Grady, S., Johnson, T., Hammond, J., Gunn, H., Curtis, B., English, C., Yutuc, V., Ferrier, C., Sackett, G. P., Marti, C. N., Young, K., Hewitson, L., & German, D. C. Proceedings of the National Academy of Sciences, 112(40):12498–12503, October, 2015. ![Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Some anecdotal reports suggest that ASD is related to exposure to ethyl mercury, in the form of the vaccine preservative, thimerosal, and/or receiving the measles, mumps, rubella (MMR) vaccine. Using infant rhesus macaques receiving thimerosal-containing vaccines (TCVs) following the recommended pediatric vaccine schedules from the 1990s and 2008, we examined behavior, and neuropathology in three brain regions found to exhibit neuropathology in postmortem ASD brains. No neuronal cellular or protein changes in the cerebellum, hippocampus, or amygdala were observed in animals following the 1990s or 2008 vaccine schedules. Analysis of social behavior in juvenile animals indicated that there were no significant differences in negative behaviors between animals in the control and experimental groups. These data indicate that administration of TCVs and/or the MMR vaccine to rhesus macaques does not result in neuropathological abnormalities, or aberrant behaviors, like those observed in ASD.
@article{gadad_administration_2015,
title = {Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology},
volume = {112},
copyright = {© . Freely available online through the PNAS open access option.},
issn = {0027-8424, 1091-6490},
url = {https://www.pnas.org/content/112/40/12498},
doi = {10.1073/pnas.1500968112},
abstract = {Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Some anecdotal reports suggest that ASD is related to exposure to ethyl mercury, in the form of the vaccine preservative, thimerosal, and/or receiving the measles, mumps, rubella (MMR) vaccine. Using infant rhesus macaques receiving thimerosal-containing vaccines (TCVs) following the recommended pediatric vaccine schedules from the 1990s and 2008, we examined behavior, and neuropathology in three brain regions found to exhibit neuropathology in postmortem ASD brains. No neuronal cellular or protein changes in the cerebellum, hippocampus, or amygdala were observed in animals following the 1990s or 2008 vaccine schedules. Analysis of social behavior in juvenile animals indicated that there were no significant differences in negative behaviors between animals in the control and experimental groups. These data indicate that administration of TCVs and/or the MMR vaccine to rhesus macaques does not result in neuropathological abnormalities, or aberrant behaviors, like those observed in ASD.},
language = {en},
number = {40},
urldate = {2019-05-14},
journal = {Proceedings of the National Academy of Sciences},
author = {Gadad, Bharathi S. and Li, Wenhao and Yazdani, Umar and Grady, Stephen and Johnson, Trevor and Hammond, Jacob and Gunn, Howard and Curtis, Britni and English, Chris and Yutuc, Vernon and Ferrier, Clayton and Sackett, Gene P. and Marti, C. Nathan and Young, Keith and Hewitson, Laura and German, Dwight C.},
month = oct,
year = {2015},
pmid = {26417083},
keywords = {PRINTED (Fonds papier), Unclassified, autism, neuropathology, pediatric vaccines, rhesus macaque, thimerosal},
pages = {12498--12503},
}
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