Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation. Gage, N. M., Juranek, J., Filipek, P. A., Osann, K., Flodman, P., Isenberg, A. L., & Spence, M. A. Journal of Neurodevelopmental Disorders, 1(3):205–214, 2009.
doi  abstract   bibtex   
PURPOSE: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. METHODS: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals. RESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age. CONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users.
@article{gage_rightward_2009,
	title = {Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an {MRI} investigation},
	volume = {1},
	issn = {1866-1955},
	shorttitle = {Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder},
	doi = {10.1007/s11689-009-9010-2},
	abstract = {PURPOSE: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex.
METHODS: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals.
RESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age.
CONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry.
ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users.},
	language = {eng},
	number = {3},
	journal = {Journal of Neurodevelopmental Disorders},
	author = {Gage, Nicole M. and Juranek, Jenifer and Filipek, Pauline A. and Osann, Kathryn and Flodman, Pamela and Isenberg, A. Lisette and Spence, M. Anne},
	year = {2009},
	pmid = {19816533},
	pmcid = {PMC2758220},
	keywords = {Auditory cortex, Developmental disorder, Heschl’s gyrus, Language cortex, Posterior superior temporal gyrus, auditory cortex},
	pages = {205--214},
}

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