Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation. Gage, N. M., Juranek, J., Filipek, P. A., Osann, K., Flodman, P., Isenberg, A. L., & Spence, M. A. Journal of Neurodevelopmental Disorders, 1(3):205–214, 2009. doi abstract bibtex PURPOSE: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. METHODS: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals. RESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age. CONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users.
@article{gage_rightward_2009,
title = {Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an {MRI} investigation},
volume = {1},
issn = {1866-1955},
shorttitle = {Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder},
doi = {10.1007/s11689-009-9010-2},
abstract = {PURPOSE: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex.
METHODS: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals.
RESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age.
CONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry.
ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users.},
language = {eng},
number = {3},
journal = {Journal of Neurodevelopmental Disorders},
author = {Gage, Nicole M. and Juranek, Jenifer and Filipek, Pauline A. and Osann, Kathryn and Flodman, Pamela and Isenberg, A. Lisette and Spence, M. Anne},
year = {2009},
pmid = {19816533},
pmcid = {PMC2758220},
keywords = {Auditory cortex, Developmental disorder, Heschl’s gyrus, Language cortex, Posterior superior temporal gyrus, auditory cortex},
pages = {205--214},
}
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A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals. RESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age. CONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users.","language":"eng","number":"3","journal":"Journal of Neurodevelopmental Disorders","author":[{"propositions":[],"lastnames":["Gage"],"firstnames":["Nicole","M."],"suffixes":[]},{"propositions":[],"lastnames":["Juranek"],"firstnames":["Jenifer"],"suffixes":[]},{"propositions":[],"lastnames":["Filipek"],"firstnames":["Pauline","A."],"suffixes":[]},{"propositions":[],"lastnames":["Osann"],"firstnames":["Kathryn"],"suffixes":[]},{"propositions":[],"lastnames":["Flodman"],"firstnames":["Pamela"],"suffixes":[]},{"propositions":[],"lastnames":["Isenberg"],"firstnames":["A.","Lisette"],"suffixes":[]},{"propositions":[],"lastnames":["Spence"],"firstnames":["M.","Anne"],"suffixes":[]}],"year":"2009","pmid":"19816533","pmcid":"PMC2758220","keywords":"Auditory cortex, Developmental disorder, Heschl’s gyrus, Language cortex, Posterior superior temporal gyrus, auditory cortex","pages":"205–214","bibtex":"@article{gage_rightward_2009,\n\ttitle = {Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an {MRI} investigation},\n\tvolume = {1},\n\tissn = {1866-1955},\n\tshorttitle = {Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder},\n\tdoi = {10.1007/s11689-009-9010-2},\n\tabstract = {PURPOSE: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex.\nMETHODS: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals.\nRESULTS: (i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age.\nCONCLUSIONS: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry.\nELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Neurodevelopmental Disorders},\n\tauthor = {Gage, Nicole M. and Juranek, Jenifer and Filipek, Pauline A. and Osann, Kathryn and Flodman, Pamela and Isenberg, A. Lisette and Spence, M. Anne},\n\tyear = {2009},\n\tpmid = {19816533},\n\tpmcid = {PMC2758220},\n\tkeywords = {Auditory cortex, Developmental disorder, Heschl’s gyrus, Language cortex, Posterior superior temporal gyrus, auditory cortex},\n\tpages = {205--214},\n}\n\n\n\n","author_short":["Gage, N. M.","Juranek, J.","Filipek, P. A.","Osann, K.","Flodman, P.","Isenberg, A. L.","Spence, M. 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