@article{gagneur_impact_2011,
	title = {Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: {The} {IVANHOE} study},
	volume = {29},
	issn = {0264-410X},
	shorttitle = {Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea},
	url = {http://www.sciencedirect.com/science/article/B6TD4-52G7XJK-1/2/ab17f59cc151140ad4811a8ce16e743d},
	doi = {10.1016/j.vaccine.2011.03.035},
	abstract = {{\textless}p{\textgreater}{\textless}br/{\textgreater}The aim of the IVANHOE study was to determine the real-world impact of the rotavirus vaccine, controlling for epidemic-to-epidemic variation in disease burden.{\textless}br/{\textgreater}A population-based prospective cohort study was conducted in Brest City and 7 suburban districts (CUB area), North-western Brittany, France (210,000 inhabitants; 5500 births per year). The vaccination program started in May 2007 for a 2-year period for all infants born in the Brest birth zone through pediatricians, public outpatient clinics and general practitioners. To determine vaccine impact we monitored trends in hospitalizations for rotavirus-specific diarrhea using an active hospital-based surveillance system initiated 5 years before vaccine introduction. The number of hospitalizations for rotavirus-specific diarrhea during the 2008/2009 epidemic in infants less than 2 years of age whose parents lived within the CUB area was modelled as a function of (1) the number of hospitalizations in infants 2-5 years of age to control for epidemic-to-epidemic variation and (2) vaccine introduction. A total of 4684 infants received at least one dose. Of these, 2635 lived within the CUB area. Vaccine coverage for a complete schedule in the CUB area was 47.1\%. Poisson modelling revealed a reduction by a factor of 2.04 (1.56-2.66) in the number of hospitalizations during the last epidemic season (2008/2009), the number of observed cases being equal to 30, against an expected number of 61. Relative risk reduction for hospitalizations for rotavirus diarrhea was 98\% (95\% CI: 83-100\%). We observed a noticeable impact of vaccination on rotavirus diarrhea hospitalizations within 2 years of vaccine introduction integrating for the first time rotavirus epidemics variation. The trial is registered with ClinicalTrials.gov, number, NCT00740935.{\textless}/p{\textgreater}},
	number = {21},
	urldate = {2011-05-06},
	journal = {Vaccine},
	author = {Gagneur, Arnaud and Nowak, Emmanuel and Lemaitre, Thomas and Segura, Jean-Francois and Delaperrière, Nadège and Abalea, Lydie and Poulhazan, Elise and Jossens, Anne and Auzanneau, Lucie and Tran, Adissa and Payan, Christopher and Jay, Nadine and de Parscau, Loic and Oger, Emmanuel},
	month = may,
	year = {2011},
	keywords = {\#duplicates, Impact on hospitalizations, Rotavirus, Rotavirus vaccine, Universal vaccination},
	pages = {3753--3759},
}

{"_id":"SgRGwbuoXth7YdRqt","bibbaseid":"gagneur-nowak-lemaitre-segura-delaperrire-abalea-poulhazan-jossens-etal-impactofrotavirusvaccinationonhospitalizationsforrotavirusdiarrheatheivanhoestudy-2011","author_short":["Gagneur, A.","Nowak, E.","Lemaitre, T.","Segura, J.","Delaperrière, N.","Abalea, L.","Poulhazan, E.","Jossens, A.","Auzanneau, L.","Tran, A.","Payan, C.","Jay, N.","de Parscau, L.","Oger, E."],"bibdata":{"bibtype":"article","type":"article","title":"Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: The IVANHOE study","volume":"29","issn":"0264-410X","shorttitle":"Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea","url":"http://www.sciencedirect.com/science/article/B6TD4-52G7XJK-1/2/ab17f59cc151140ad4811a8ce16e743d","doi":"10.1016/j.vaccine.2011.03.035","abstract":"\\textlessp\\textgreater\\textlessbr/\\textgreaterThe aim of the IVANHOE study was to determine the real-world impact of the rotavirus vaccine, controlling for epidemic-to-epidemic variation in disease burden.\\textlessbr/\\textgreaterA population-based prospective cohort study was conducted in Brest City and 7 suburban districts (CUB area), North-western Brittany, France (210,000 inhabitants; 5500 births per year). The vaccination program started in May 2007 for a 2-year period for all infants born in the Brest birth zone through pediatricians, public outpatient clinics and general practitioners. To determine vaccine impact we monitored trends in hospitalizations for rotavirus-specific diarrhea using an active hospital-based surveillance system initiated 5 years before vaccine introduction. The number of hospitalizations for rotavirus-specific diarrhea during the 2008/2009 epidemic in infants less than 2 years of age whose parents lived within the CUB area was modelled as a function of (1) the number of hospitalizations in infants 2-5 years of age to control for epidemic-to-epidemic variation and (2) vaccine introduction. A total of 4684 infants received at least one dose. Of these, 2635 lived within the CUB area. Vaccine coverage for a complete schedule in the CUB area was 47.1%. Poisson modelling revealed a reduction by a factor of 2.04 (1.56-2.66) in the number of hospitalizations during the last epidemic season (2008/2009), the number of observed cases being equal to 30, against an expected number of 61. Relative risk reduction for hospitalizations for rotavirus diarrhea was 98% (95% CI: 83-100%). We observed a noticeable impact of vaccination on rotavirus diarrhea hospitalizations within 2 years of vaccine introduction integrating for the first time rotavirus epidemics variation. The trial is registered with ClinicalTrials.gov, number, NCT00740935.\\textless/p\\textgreater","number":"21","urldate":"2011-05-06","journal":"Vaccine","author":[{"propositions":[],"lastnames":["Gagneur"],"firstnames":["Arnaud"],"suffixes":[]},{"propositions":[],"lastnames":["Nowak"],"firstnames":["Emmanuel"],"suffixes":[]},{"propositions":[],"lastnames":["Lemaitre"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Segura"],"firstnames":["Jean-Francois"],"suffixes":[]},{"propositions":[],"lastnames":["Delaperrière"],"firstnames":["Nadège"],"suffixes":[]},{"propositions":[],"lastnames":["Abalea"],"firstnames":["Lydie"],"suffixes":[]},{"propositions":[],"lastnames":["Poulhazan"],"firstnames":["Elise"],"suffixes":[]},{"propositions":[],"lastnames":["Jossens"],"firstnames":["Anne"],"suffixes":[]},{"propositions":[],"lastnames":["Auzanneau"],"firstnames":["Lucie"],"suffixes":[]},{"propositions":[],"lastnames":["Tran"],"firstnames":["Adissa"],"suffixes":[]},{"propositions":[],"lastnames":["Payan"],"firstnames":["Christopher"],"suffixes":[]},{"propositions":[],"lastnames":["Jay"],"firstnames":["Nadine"],"suffixes":[]},{"propositions":["de"],"lastnames":["Parscau"],"firstnames":["Loic"],"suffixes":[]},{"propositions":[],"lastnames":["Oger"],"firstnames":["Emmanuel"],"suffixes":[]}],"month":"May","year":"2011","keywords":"#duplicates, Impact on hospitalizations, Rotavirus, Rotavirus vaccine, Universal vaccination","pages":"3753–3759","bibtex":"@article{gagneur_impact_2011,\n\ttitle = {Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: {The} {IVANHOE} study},\n\tvolume = {29},\n\tissn = {0264-410X},\n\tshorttitle = {Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea},\n\turl = {http://www.sciencedirect.com/science/article/B6TD4-52G7XJK-1/2/ab17f59cc151140ad4811a8ce16e743d},\n\tdoi = {10.1016/j.vaccine.2011.03.035},\n\tabstract = {{\\textless}p{\\textgreater}{\\textless}br/{\\textgreater}The aim of the IVANHOE study was to determine the real-world impact of the rotavirus vaccine, controlling for epidemic-to-epidemic variation in disease burden.{\\textless}br/{\\textgreater}A population-based prospective cohort study was conducted in Brest City and 7 suburban districts (CUB area), North-western Brittany, France (210,000 inhabitants; 5500 births per year). The vaccination program started in May 2007 for a 2-year period for all infants born in the Brest birth zone through pediatricians, public outpatient clinics and general practitioners. To determine vaccine impact we monitored trends in hospitalizations for rotavirus-specific diarrhea using an active hospital-based surveillance system initiated 5 years before vaccine introduction. The number of hospitalizations for rotavirus-specific diarrhea during the 2008/2009 epidemic in infants less than 2 years of age whose parents lived within the CUB area was modelled as a function of (1) the number of hospitalizations in infants 2-5 years of age to control for epidemic-to-epidemic variation and (2) vaccine introduction. A total of 4684 infants received at least one dose. Of these, 2635 lived within the CUB area. Vaccine coverage for a complete schedule in the CUB area was 47.1\\%. Poisson modelling revealed a reduction by a factor of 2.04 (1.56-2.66) in the number of hospitalizations during the last epidemic season (2008/2009), the number of observed cases being equal to 30, against an expected number of 61. Relative risk reduction for hospitalizations for rotavirus diarrhea was 98\\% (95\\% CI: 83-100\\%). We observed a noticeable impact of vaccination on rotavirus diarrhea hospitalizations within 2 years of vaccine introduction integrating for the first time rotavirus epidemics variation. The trial is registered with ClinicalTrials.gov, number, NCT00740935.{\\textless}/p{\\textgreater}},\n\tnumber = {21},\n\turldate = {2011-05-06},\n\tjournal = {Vaccine},\n\tauthor = {Gagneur, Arnaud and Nowak, Emmanuel and Lemaitre, Thomas and Segura, Jean-Francois and Delaperrière, Nadège and Abalea, Lydie and Poulhazan, Elise and Jossens, Anne and Auzanneau, Lucie and Tran, Adissa and Payan, Christopher and Jay, Nadine and de Parscau, Loic and Oger, Emmanuel},\n\tmonth = may,\n\tyear = {2011},\n\tkeywords = {\\#duplicates, Impact on hospitalizations, Rotavirus, Rotavirus vaccine, Universal vaccination},\n\tpages = {3753--3759},\n}\n\n","author_short":["Gagneur, A.","Nowak, E.","Lemaitre, T.","Segura, J.","Delaperrière, N.","Abalea, L.","Poulhazan, E.","Jossens, A.","Auzanneau, L.","Tran, A.","Payan, C.","Jay, N.","de Parscau, L.","Oger, E."],"key":"gagneur_impact_2011","id":"gagneur_impact_2011","bibbaseid":"gagneur-nowak-lemaitre-segura-delaperrire-abalea-poulhazan-jossens-etal-impactofrotavirusvaccinationonhospitalizationsforrotavirusdiarrheatheivanhoestudy-2011","role":"author","urls":{"Paper":"http://www.sciencedirect.com/science/article/B6TD4-52G7XJK-1/2/ab17f59cc151140ad4811a8ce16e743d"},"keyword":["#duplicates","Impact on hospitalizations","Rotavirus","Rotavirus vaccine","Universal vaccination"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":["#duplicates","impact on hospitalizations","rotavirus","rotavirus vaccine","universal vaccination"],"search_terms":["impact","rotavirus","vaccination","hospitalizations","rotavirus","diarrhea","ivanhoe","study","gagneur","nowak","lemaitre","segura","delaperrière","abalea","poulhazan","jossens","auzanneau","tran","payan","jay","de parscau","oger"],"title":"Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: The IVANHOE study","year":2011}