MRI-Guided Stereotactic Biopsy of Murine GBM for Spatiotemporal Molecular Genomic Assessment. Galbán, S., Al-Holou, W. N., Wang, H., Welton, A. R., Heist, K., Hu, X. K., Verhaak, R. G., Zhu, Y., Espinoza, C., Chenevert, T. L., Hoff, B. A., Galbán, C. J., & Ross, B. D. Tomography, 3(1):9-15, 2017. 2379-139x Galbán, Stefanie Al-Holou, Wajd N Wang, Hanxiao Welton, Amanda R Heist, Kevin Hu, Xin Kathy Verhaak, Roeland Gw Zhu, Yuan Espinoza, Carlos Chenevert, Thomas L Hoff, Ben A Galbán, Craig J Ross, Brian D P01 CA085878/CA/NCI NIH HHS/United States R35 CA197701/CA/NCI NIH HHS/United States R35 CA197707/CA/NCI NIH HHS/United States Journal Article Switzerland 2017/05/30 Tomography. 2017 Mar;3(1):9-15. doi: 10.18383/j.tom.2017.00112.
doi  abstract   bibtex   
Brain tumor biopsies that are routinely performed in clinical settings significantly aid in diagnosis and staging. The aim of this study is to develop and evaluate a methodological image-guided approach that would allow for routine sampling of glioma tissue from orthotopic mouse brain tumor models. A magnetic resonance imaging-guided biopsy method is presented to allow for spatially precise stereotaxic sampling of a murine glioma coupled with genome-scale technology to provide unbiased characterization of intra- and intertumoral clonal heterogeneity. Longitudinal and multiregional sampling of intracranial tumors allows for successful collection of tumor biopsy samples, thus allowing for a pathway-enrichment analysis and a transcriptional profiling of RNA sequencing data. Spatiotemporal gene expression pattern variations revealing genomic heterogeneity were found.
@article{RN6109,
   author = {Galbán, S. and Al-Holou, W. N. and Wang, H. and Welton, A. R. and Heist, K. and Hu, X. K. and Verhaak, R. G. and Zhu, Y. and Espinoza, C. and Chenevert, T. L. and Hoff, B. A. and Galbán, C. J. and Ross, B. D.},
   title = {MRI-Guided Stereotactic Biopsy of Murine GBM for Spatiotemporal Molecular Genomic Assessment},
   journal = {Tomography},
   volume = {3},
   number = {1},
   pages = {9-15},
   note = {2379-139x
Galbán, Stefanie
Al-Holou, Wajd N
Wang, Hanxiao
Welton, Amanda R
Heist, Kevin
Hu, Xin Kathy
Verhaak, Roeland Gw
Zhu, Yuan
Espinoza, Carlos
Chenevert, Thomas L
Hoff, Ben A
Galbán, Craig J
Ross, Brian D
P01 CA085878/CA/NCI NIH HHS/United States
R35 CA197701/CA/NCI NIH HHS/United States
R35 CA197707/CA/NCI NIH HHS/United States
Journal Article
Switzerland
2017/05/30
Tomography. 2017 Mar;3(1):9-15. doi: 10.18383/j.tom.2017.00112.},
   abstract = {Brain tumor biopsies that are routinely performed in clinical settings significantly aid in diagnosis and staging. The aim of this study is to develop and evaluate a methodological image-guided approach that would allow for routine sampling of glioma tissue from orthotopic mouse brain tumor models. A magnetic resonance imaging-guided biopsy method is presented to allow for spatially precise stereotaxic sampling of a murine glioma coupled with genome-scale technology to provide unbiased characterization of intra- and intertumoral clonal heterogeneity. Longitudinal and multiregional sampling of intracranial tumors allows for successful collection of tumor biopsy samples, thus allowing for a pathway-enrichment analysis and a transcriptional profiling of RNA sequencing data. Spatiotemporal gene expression pattern variations revealing genomic heterogeneity were found.},
   keywords = {MRI-guided biopsy
genomic analysis
glioma
murine studies},
   ISSN = {2379-1381 (Print)
2379-1381},
   DOI = {10.18383/j.tom.2017.00112},
   year = {2017},
   type = {Journal Article}
}

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