@article{ganten_role_2013,
	title = {The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging},
	volume = {13},
	issn = {1470-7330},
	doi = {10.1102/1470-7330.2013.0045},
	abstract = {PURPOSE: The aim of this study was to characterize and understand the therapy-induced changes in diffusion parameters in rectal carcinoma under chemoradiotherapy (CRT). The current literature shows conflicting results in this regard. We applied the intravoxel incoherent motion model, which allows for the differentiation between diffusion (D) and perfusion (f) effects, to further elucidate potential underlying causes for these divergent reports.
MATERIALS AND METHODS: Eighteen patients with primary rectal carcinoma undergoing preoperative CRT were examined before, during, and after neoadjuvant CRT using diffusion-weighted imaging. Using the intravoxel incoherent motion approach, f and D were extracted and compared with postoperative tumor downstaging and volume.
RESULTS: Initial diffusion-derived parameters were within a narrow range (D1 = 0.94 ± 0.12 × 10(-3) mm(2)/s). At follow-up, D rose significantly (D2 = 1.18 ± 0.13 × 10(-3) mm(2)/s; P {\textless} 0.0001) and continued to increase significantly after CRT (D3 = 1.24 ± 0.14 × 10(-3) mm(2)/s; P {\textless} 0.0001). The perfusion fraction f did not change significantly (f1 = 9.4 ± 2.0\%, f2 = 9.4 ± 1.7\%, f3 = 9.5 ± 2.7\%). Mean volume (V) decreased significantly (V1 = 16,992 ± 13,083 mm(3); V2 = 12,793 ± 8317 mm(3), V3 = 9718 ± 6154 mm(3)). T-downstaging (10:18 patients) showed no significant correlation with diffusion-derived parameters.
CONCLUSIONS: Conflicting results in the literature considering apparent diffusion coefficient (ADC) changes in rectal carcinoma under CRT for patients showing T-downstaging are unlikely to be due to perfusion effects. Our data support the view that under effective therapy, an increase in D/ADC can be observed.},
	language = {eng},
	number = {4},
	journal = {Cancer Imaging: The Official Publication of the International Cancer Imaging Society},
	author = {Ganten, Maria-Katharina and Schuessler, Maximilian and Bäuerle, Tobias and Muenter, Marc and Schlemmer, Heinz-Peter and Jensen, Alexandra and Brand, Karsten and Dueck, Margret and Dinkel, Julien and Kopp-Schneider, Annette and Maier-Hein*, Klaus and Stieltjes, Bram},
	year = {2013},
	keywords = {Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Rectal Neoplasms, Tumor Burden},
	pages = {548--556}
}

{"_id":"3EEnc4knmBnTBCxQD","bibbaseid":"ganten-schuessler-buerle-muenter-schlemmer-jensen-brand-dueck-etal-theroleofperfusioneffectsinmonitoringofchemoradiotherapyofrectalcarcinomausingdiffusionweightedimaging-2013","downloads":0,"creationDate":"2016-10-10T12:56:32.418Z","title":"The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging","author_short":["Ganten, M.","Schuessler, M.","Bäuerle, T.","Muenter, M.","Schlemmer, H.","Jensen, A.","Brand, K.","Dueck, M.","Dinkel, J.","Kopp-Schneider, A.","Maier-Hein*, K.","Stieltjes, B."],"year":2013,"bibtype":"article","biburl":"https://api.zotero.org/groups/362666/items?key=FY3nzUc8WtPuMJZ79bIeuOyf&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging","volume":"13","issn":"1470-7330","doi":"10.1102/1470-7330.2013.0045","abstract":"PURPOSE: The aim of this study was to characterize and understand the therapy-induced changes in diffusion parameters in rectal carcinoma under chemoradiotherapy (CRT). The current literature shows conflicting results in this regard. We applied the intravoxel incoherent motion model, which allows for the differentiation between diffusion (D) and perfusion (f) effects, to further elucidate potential underlying causes for these divergent reports. MATERIALS AND METHODS: Eighteen patients with primary rectal carcinoma undergoing preoperative CRT were examined before, during, and after neoadjuvant CRT using diffusion-weighted imaging. Using the intravoxel incoherent motion approach, f and D were extracted and compared with postoperative tumor downstaging and volume. RESULTS: Initial diffusion-derived parameters were within a narrow range (D1 = 0.94 ± 0.12 × 10(-3) mm(2)/s). At follow-up, D rose significantly (D2 = 1.18 ± 0.13 × 10(-3) mm(2)/s; P \\textless 0.0001) and continued to increase significantly after CRT (D3 = 1.24 ± 0.14 × 10(-3) mm(2)/s; P \\textless 0.0001). The perfusion fraction f did not change significantly (f1 = 9.4 ± 2.0%, f2 = 9.4 ± 1.7%, f3 = 9.5 ± 2.7%). Mean volume (V) decreased significantly (V1 = 16,992 ± 13,083 mm(3); V2 = 12,793 ± 8317 mm(3), V3 = 9718 ± 6154 mm(3)). T-downstaging (10:18 patients) showed no significant correlation with diffusion-derived parameters. CONCLUSIONS: Conflicting results in the literature considering apparent diffusion coefficient (ADC) changes in rectal carcinoma under CRT for patients showing T-downstaging are unlikely to be due to perfusion effects. Our data support the view that under effective therapy, an increase in D/ADC can be observed.","language":"eng","number":"4","journal":"Cancer Imaging: The Official Publication of the International Cancer Imaging Society","author":[{"propositions":[],"lastnames":["Ganten"],"firstnames":["Maria-Katharina"],"suffixes":[]},{"propositions":[],"lastnames":["Schuessler"],"firstnames":["Maximilian"],"suffixes":[]},{"propositions":[],"lastnames":["Bäuerle"],"firstnames":["Tobias"],"suffixes":[]},{"propositions":[],"lastnames":["Muenter"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Schlemmer"],"firstnames":["Heinz-Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Jensen"],"firstnames":["Alexandra"],"suffixes":[]},{"propositions":[],"lastnames":["Brand"],"firstnames":["Karsten"],"suffixes":[]},{"propositions":[],"lastnames":["Dueck"],"firstnames":["Margret"],"suffixes":[]},{"propositions":[],"lastnames":["Dinkel"],"firstnames":["Julien"],"suffixes":[]},{"propositions":[],"lastnames":["Kopp-Schneider"],"firstnames":["Annette"],"suffixes":[]},{"propositions":[],"lastnames":["Maier-Hein*"],"firstnames":["Klaus"],"suffixes":[]},{"propositions":[],"lastnames":["Stieltjes"],"firstnames":["Bram"],"suffixes":[]}],"year":"2013","keywords":"Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Rectal Neoplasms, Tumor Burden","pages":"548--556","bibtex":"@article{ganten_role_2013,\n\ttitle = {The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging},\n\tvolume = {13},\n\tissn = {1470-7330},\n\tdoi = {10.1102/1470-7330.2013.0045},\n\tabstract = {PURPOSE: The aim of this study was to characterize and understand the therapy-induced changes in diffusion parameters in rectal carcinoma under chemoradiotherapy (CRT). The current literature shows conflicting results in this regard. We applied the intravoxel incoherent motion model, which allows for the differentiation between diffusion (D) and perfusion (f) effects, to further elucidate potential underlying causes for these divergent reports.\nMATERIALS AND METHODS: Eighteen patients with primary rectal carcinoma undergoing preoperative CRT were examined before, during, and after neoadjuvant CRT using diffusion-weighted imaging. Using the intravoxel incoherent motion approach, f and D were extracted and compared with postoperative tumor downstaging and volume.\nRESULTS: Initial diffusion-derived parameters were within a narrow range (D1 = 0.94 ± 0.12 × 10(-3) mm(2)/s). At follow-up, D rose significantly (D2 = 1.18 ± 0.13 × 10(-3) mm(2)/s; P {\\textless} 0.0001) and continued to increase significantly after CRT (D3 = 1.24 ± 0.14 × 10(-3) mm(2)/s; P {\\textless} 0.0001). The perfusion fraction f did not change significantly (f1 = 9.4 ± 2.0\\%, f2 = 9.4 ± 1.7\\%, f3 = 9.5 ± 2.7\\%). Mean volume (V) decreased significantly (V1 = 16,992 ± 13,083 mm(3); V2 = 12,793 ± 8317 mm(3), V3 = 9718 ± 6154 mm(3)). T-downstaging (10:18 patients) showed no significant correlation with diffusion-derived parameters.\nCONCLUSIONS: Conflicting results in the literature considering apparent diffusion coefficient (ADC) changes in rectal carcinoma under CRT for patients showing T-downstaging are unlikely to be due to perfusion effects. Our data support the view that under effective therapy, an increase in D/ADC can be observed.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Cancer Imaging: The Official Publication of the International Cancer Imaging Society},\n\tauthor = {Ganten, Maria-Katharina and Schuessler, Maximilian and Bäuerle, Tobias and Muenter, Marc and Schlemmer, Heinz-Peter and Jensen, Alexandra and Brand, Karsten and Dueck, Margret and Dinkel, Julien and Kopp-Schneider, Annette and Maier-Hein*, Klaus and Stieltjes, Bram},\n\tyear = {2013},\n\tkeywords = {Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Rectal Neoplasms, Tumor Burden},\n\tpages = {548--556}\n}\n\n","author_short":["Ganten, M.","Schuessler, M.","Bäuerle, T.","Muenter, M.","Schlemmer, H.","Jensen, A.","Brand, K.","Dueck, M.","Dinkel, J.","Kopp-Schneider, A.","Maier-Hein*, K.","Stieltjes, B."],"key":"ganten_role_2013","id":"ganten_role_2013","bibbaseid":"ganten-schuessler-buerle-muenter-schlemmer-jensen-brand-dueck-etal-theroleofperfusioneffectsinmonitoringofchemoradiotherapyofrectalcarcinomausingdiffusionweightedimaging-2013","role":"author","urls":{},"keyword":["Adult","Aged","Aged","80 and over","Chemoradiotherapy","Diffusion Magnetic Resonance Imaging","Female","Humans","Male","Middle Aged","Rectal Neoplasms","Tumor Burden"],"downloads":0},"search_terms":["role","perfusion","effects","monitoring","chemoradiotherapy","rectal","carcinoma","using","diffusion","weighted","imaging","ganten","schuessler","bäuerle","muenter","schlemmer","jensen","brand","dueck","dinkel","kopp-schneider","maier-hein*","stieltjes"],"keywords":["adult","aged","aged","80 and over","chemoradiotherapy","diffusion magnetic resonance imaging","female","humans","male","middle aged","rectal neoplasms","tumor burden"],"authorIDs":[],"dataSources":["8WwpcKoYgmySpYkXy"]}