Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?. Garabedian, C., Sfeir, R., Langlois, C., Bonnard, A., Khen-Dunlop, N., Gelas, T., Michaud, L., Auber, F., Gottrand, F., Houfflin-Debarge, V., & French Network on Esophageal Atresia American Journal of Obstetrics and Gynecology, 212(3):340.e1–7, March, 2015. ![Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia? [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OBJECTIVE: Our study aimed at (1) evaluating neonatal treatment and outcome of neonates with either a prenatal or a postnatal diagnosis of esophageal atresia (EA) and (2) analyzing the impact of prenatal diagnosis on outcome based on the type of EA. STUDY DESIGN: We conducted a population-based study using data from the French National Register for infants with EA born from 2008-2010. We compared prenatal, maternal, and neonatal characteristics among children with prenatal vs postnatal diagnosis and EA types I and III. We defined a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and death at 1 year. RESULTS: Four hundred sixty-nine live births with EA were recorded with a prenatal diagnosis rate of 24.3%; 82.2% of EA type I were diagnosed prenatally compared with 17.9% of EA type III (P \textless .001). Transfer after birth was lower in case of prenatal diagnosis (25.6% vs 82.5%; P \textless .001). The delay between birth and first intervention did not differ significantly among groups. The defect size was longer among the prenatal diagnosis group (2.61 vs 1.48 cm; P \textless .001). The composite variables were higher in prenatal diagnosis subset (44% vs 27.6%; P = .003) and in EA type I than in type III (58.1% vs 28.3%; P \textless .001). CONCLUSION: Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity rate related to the EA type (type I and/or long gap). Even though it does not modify neonatal treatment and the 1-year outcome, prenatal diagnosis allows antenatal parental counselling and avoids postnatal transfers.
@article{garabedian_does_2015,
title = {Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?},
volume = {212},
issn = {1097-6868},
url = {https://pubmed.ncbi.nlm.nih.gov/25265404/},
doi = {10.1016/j.ajog.2014.09.030},
abstract = {OBJECTIVE: Our study aimed at (1) evaluating neonatal treatment and outcome of neonates with either a prenatal or a postnatal diagnosis of esophageal atresia (EA) and (2) analyzing the impact of prenatal diagnosis on outcome based on the type of EA.
STUDY DESIGN: We conducted a population-based study using data from the French National Register for infants with EA born from 2008-2010. We compared prenatal, maternal, and neonatal characteristics among children with prenatal vs postnatal diagnosis and EA types I and III. We defined a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and death at 1 year.
RESULTS: Four hundred sixty-nine live births with EA were recorded with a prenatal diagnosis rate of 24.3\%; 82.2\% of EA type I were diagnosed prenatally compared with 17.9\% of EA type III (P {\textless} .001). Transfer after birth was lower in case of prenatal diagnosis (25.6\% vs 82.5\%; P {\textless} .001). The delay between birth and first intervention did not differ significantly among groups. The defect size was longer among the prenatal diagnosis group (2.61 vs 1.48 cm; P {\textless} .001). The composite variables were higher in prenatal diagnosis subset (44\% vs 27.6\%; P = .003) and in EA type I than in type III (58.1\% vs 28.3\%; P {\textless} .001).
CONCLUSION: Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity rate related to the EA type (type I and/or long gap). Even though it does not modify neonatal treatment and the 1-year outcome, prenatal diagnosis allows antenatal parental counselling and avoids postnatal transfers.},
language = {eng},
number = {3},
journal = {American Journal of Obstetrics and Gynecology},
author = {Garabedian, Charles and Sfeir, Rony and Langlois, Carole and Bonnard, Arnaud and Khen-Dunlop, Naziha and Gelas, Thomas and Michaud, Laurent and Auber, Fréderic and Gottrand, Fréderic and Houfflin-Debarge, Véronique and {French Network on Esophageal Atresia}},
month = mar,
year = {2015},
keywords = {Combined Modality Therapy, Esophageal Atresia, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Pregnancy, Prenatal Diagnosis, Registries, Survival Analysis, Treatment Outcome, associated anomaly, esophageal atresia, outcome, postnatal diagnosis, prenatal diagnosis},
pages = {340.e1--7},
}
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STUDY DESIGN: We conducted a population-based study using data from the French National Register for infants with EA born from 2008-2010. We compared prenatal, maternal, and neonatal characteristics among children with prenatal vs postnatal diagnosis and EA types I and III. We defined a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and death at 1 year. RESULTS: Four hundred sixty-nine live births with EA were recorded with a prenatal diagnosis rate of 24.3%; 82.2% of EA type I were diagnosed prenatally compared with 17.9% of EA type III (P \\textless .001). Transfer after birth was lower in case of prenatal diagnosis (25.6% vs 82.5%; P \\textless .001). The delay between birth and first intervention did not differ significantly among groups. The defect size was longer among the prenatal diagnosis group (2.61 vs 1.48 cm; P \\textless .001). The composite variables were higher in prenatal diagnosis subset (44% vs 27.6%; P = .003) and in EA type I than in type III (58.1% vs 28.3%; P \\textless .001). CONCLUSION: Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity rate related to the EA type (type I and/or long gap). Even though it does not modify neonatal treatment and the 1-year outcome, prenatal diagnosis allows antenatal parental counselling and avoids postnatal transfers.","language":"eng","number":"3","journal":"American Journal of Obstetrics and Gynecology","author":[{"propositions":[],"lastnames":["Garabedian"],"firstnames":["Charles"],"suffixes":[]},{"propositions":[],"lastnames":["Sfeir"],"firstnames":["Rony"],"suffixes":[]},{"propositions":[],"lastnames":["Langlois"],"firstnames":["Carole"],"suffixes":[]},{"propositions":[],"lastnames":["Bonnard"],"firstnames":["Arnaud"],"suffixes":[]},{"propositions":[],"lastnames":["Khen-Dunlop"],"firstnames":["Naziha"],"suffixes":[]},{"propositions":[],"lastnames":["Gelas"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Michaud"],"firstnames":["Laurent"],"suffixes":[]},{"propositions":[],"lastnames":["Auber"],"firstnames":["Fréderic"],"suffixes":[]},{"propositions":[],"lastnames":["Gottrand"],"firstnames":["Fréderic"],"suffixes":[]},{"propositions":[],"lastnames":["Houfflin-Debarge"],"firstnames":["Véronique"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["French Network on Esophageal Atresia"],"suffixes":[]}],"month":"March","year":"2015","keywords":"Combined Modality Therapy, Esophageal Atresia, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Pregnancy, Prenatal Diagnosis, Registries, Survival Analysis, Treatment Outcome, associated anomaly, esophageal atresia, outcome, postnatal diagnosis, prenatal diagnosis","pages":"340.e1–7","bibtex":"@article{garabedian_does_2015,\n\ttitle = {Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?},\n\tvolume = {212},\n\tissn = {1097-6868},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/25265404/},\n\tdoi = {10.1016/j.ajog.2014.09.030},\n\tabstract = {OBJECTIVE: Our study aimed at (1) evaluating neonatal treatment and outcome of neonates with either a prenatal or a postnatal diagnosis of esophageal atresia (EA) and (2) analyzing the impact of prenatal diagnosis on outcome based on the type of EA.\nSTUDY DESIGN: We conducted a population-based study using data from the French National Register for infants with EA born from 2008-2010. We compared prenatal, maternal, and neonatal characteristics among children with prenatal vs postnatal diagnosis and EA types I and III. We defined a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and death at 1 year.\nRESULTS: Four hundred sixty-nine live births with EA were recorded with a prenatal diagnosis rate of 24.3\\%; 82.2\\% of EA type I were diagnosed prenatally compared with 17.9\\% of EA type III (P {\\textless} .001). Transfer after birth was lower in case of prenatal diagnosis (25.6\\% vs 82.5\\%; P {\\textless} .001). The delay between birth and first intervention did not differ significantly among groups. The defect size was longer among the prenatal diagnosis group (2.61 vs 1.48 cm; P {\\textless} .001). The composite variables were higher in prenatal diagnosis subset (44\\% vs 27.6\\%; P = .003) and in EA type I than in type III (58.1\\% vs 28.3\\%; P {\\textless} .001).\nCONCLUSION: Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity rate related to the EA type (type I and/or long gap). Even though it does not modify neonatal treatment and the 1-year outcome, prenatal diagnosis allows antenatal parental counselling and avoids postnatal transfers.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {American Journal of Obstetrics and Gynecology},\n\tauthor = {Garabedian, Charles and Sfeir, Rony and Langlois, Carole and Bonnard, Arnaud and Khen-Dunlop, Naziha and Gelas, Thomas and Michaud, Laurent and Auber, Fréderic and Gottrand, Fréderic and Houfflin-Debarge, Véronique and {French Network on Esophageal Atresia}},\n\tmonth = mar,\n\tyear = {2015},\n\tkeywords = {Combined Modality Therapy, Esophageal Atresia, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Pregnancy, Prenatal Diagnosis, Registries, Survival Analysis, Treatment Outcome, associated anomaly, esophageal atresia, outcome, postnatal diagnosis, prenatal diagnosis},\n\tpages = {340.e1--7},\n}\n\n\n\n","author_short":["Garabedian, C.","Sfeir, R.","Langlois, C.","Bonnard, A.","Khen-Dunlop, N.","Gelas, T.","Michaud, L.","Auber, F.","Gottrand, F.","Houfflin-Debarge, V.","French Network on Esophageal Atresia"],"key":"garabedian_does_2015","id":"garabedian_does_2015","bibbaseid":"garabedian-sfeir-langlois-bonnard-khendunlop-gelas-michaud-auber-etal-doesprenataldiagnosismodifyneonataltreatmentandearlyoutcomeofchildrenwithesophagealatresia-2015","role":"author","urls":{"Paper":"https://pubmed.ncbi.nlm.nih.gov/25265404/"},"keyword":["Combined Modality Therapy","Esophageal Atresia","Female","Follow-Up Studies","Humans","Infant","Infant","Newborn","Pregnancy","Prenatal Diagnosis","Registries","Survival Analysis","Treatment Outcome","associated anomaly","esophageal atresia","outcome","postnatal diagnosis","prenatal diagnosis"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero-group/Leromela/5826776","dataSources":["xEepG2Bu5H8yCXNLe","9KDMJQgGj9aC6ujCM","tJu2LQsng3WaoKpcL","epXRk2zQpWZQCqqGz"],"keywords":["combined modality therapy","esophageal atresia","female","follow-up studies","humans","infant","infant","newborn","pregnancy","prenatal diagnosis","registries","survival analysis","treatment outcome","associated anomaly","esophageal atresia","outcome","postnatal diagnosis","prenatal diagnosis"],"search_terms":["prenatal","diagnosis","modify","neonatal","treatment","early","outcome","children","esophageal","atresia","garabedian","sfeir","langlois","bonnard","khen-dunlop","gelas","michaud","auber","gottrand","houfflin-debarge","french network on esophageal atresia"],"title":"Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?","year":2015}