High Prevalence of Gallstone Disease in Rheumatoid Arthritis: A New Comorbidity Related to Dyslipidemia?. García-Gómez, M. C., de Lama, E., Ordoñez-Palau, S., Nolla, J. M., Corbella, E., & Pintó, X. Reumatologia Clinica, 2017.
doi  abstract   bibtex   
OBJECTIVE: To assess the prevalence of gallstone disease and identify associated risk factors in rheumatoid arthritis (RA) patients compared to the general population. METHODS: Eighty-four women with rheumatoid arthritis were included in the study. Each patient was assessed via a structured interview, physical examination, abdominal ultrasound and blood test including lipid profile. The prevalence of gallstone disease in rheumatoid arthritis was compared with data from a study of the Spanish population matched by age groups. RESULTS: Twenty-eight of the 84 women had gallstone disease (33.3%). RA women with and without gallstone disease were similar in most of the variables assessed, except for older age and menopausal status in the former. A greater prevalence of gallstone disease was seen in rheumatoid arthritis patients compared to the general population of the same age; however, the differences were significant only in women aged 60 or older (45.5% versus 23.1% respectively, P-value .008). The age-adjusted OR of developing gallstone disease in RA women compared with general population women was 2,3 (95% CI: 1.3-4.1). A significantly higher HDL3-c subfraction and higher apoA-I/HDL and HDL3-c/TC ratios were observed in patients with gallstone disease. CONCLUSION: Women with rheumatoid arthritis may have a predisposition to gallstones that can manifest in middle or older age compared with women in the general population. This situation could be related to chronic inflammation and HDL metabolism.
@article{garcia-gomez_high_2017,
	title = {High {Prevalence} of {Gallstone} {Disease} in {Rheumatoid} {Arthritis}: {A} {New} {Comorbidity} {Related} to {Dyslipidemia}?},
	issn = {1885-1398},
	shorttitle = {High {Prevalence} of {Gallstone} {Disease} in {Rheumatoid} {Arthritis}},
	doi = {10.1016/j.reuma.2017.06.013},
	abstract = {OBJECTIVE: To assess the prevalence of gallstone disease and identify associated risk factors in rheumatoid arthritis (RA) patients compared to the general population.
METHODS: Eighty-four women with rheumatoid arthritis were included in the study. Each patient was assessed via a structured interview, physical examination, abdominal ultrasound and blood test including lipid profile. The prevalence of gallstone disease in rheumatoid arthritis was compared with data from a study of the Spanish population matched by age groups.
RESULTS: Twenty-eight of the 84 women had gallstone disease (33.3\%). RA women with and without gallstone disease were similar in most of the variables assessed, except for older age and menopausal status in the former. A greater prevalence of gallstone disease was seen in rheumatoid arthritis patients compared to the general population of the same age; however, the differences were significant only in women aged 60 or older (45.5\% versus 23.1\% respectively, P-value .008). The age-adjusted OR of developing gallstone disease in RA women compared with general population women was 2,3 (95\% CI: 1.3-4.1). A significantly higher HDL3-c subfraction and higher apoA-I/HDL and HDL3-c/TC ratios were observed in patients with gallstone disease.
CONCLUSION: Women with rheumatoid arthritis may have a predisposition to gallstones that can manifest in middle or older age compared with women in the general population. This situation could be related to chronic inflammation and HDL metabolism.},
	language = {eng, spa},
	journal = {Reumatologia Clinica},
	author = {García-Gómez, María Carmen and de Lama, Eugenia and Ordoñez-Palau, Sergi and Nolla, Joan Miquel and Corbella, Emili and Pintó, Xavier},
	year = {2017},
	pmid = {28778575},
	keywords = {Article, Artritis reumatoide, Cholecystectomy, Colecistectomía, Comorbidity, Comorbilidad, Gallstones, Lipids, Lipoproteins, Lipoproteínas, Litiasis biliar, Lípidos, Reumatologia, Rheumatoid arthritis},
}

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