@article{garcia_rodriguez_inverse_2004,
	title = {Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer},
	volume = {13},
	issn = {1055-9965},
	abstract = {BACKGROUND: Prostate cancer is considered a major health problem in western countries. Promising results from observational studies on cancer at other sites fuelled the publication of several studies assessing the association between nonsteroidal anti-inflammatory drug (NSAID) use and prostate cancer. However, these studies show conflicting results.
METHODS: We conducted a cohort study with a nested case-control analysis to further study the association between NSAIDs and prostate cancer. We used data from the General Practice Research Database in United Kingdom.
RESULTS: Aspirin use was associated with a reduced risk of prostate cancer [odds ratio (OR) = 0.70, 95\% confidence interval (95\% CI) = 0.61-0.79]. We also found that paracetamol use with a treatment duration longer than 1 year was associated with a decreased risk (OR = 0.65, 95\% CI = 0.54-0.78). Non-aspirin-NSAID (NA-NSAID) and paracetamol short-term use was associated with a small increased risk whereas long-term users of NA-NSAIDs presented an OR of 0.89 (95\% CI = 0.73-1.08).
DISCUSSION: Our findings support a protective effect of aspirin and paracetamol against prostate cancer. The transient elevated risk observed among newly started users of NA-NSAIDs and paracetamol is most likely explained by prothopathic bias. We found some suggestion of a reduced risk with long-term use of NA-NSAID.},
	language = {eng},
	number = {4},
	journal = {Cancer Epidemiology, Biomarkers \& Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology},
	author = {García Rodríguez, Luis A. and González-Pérez, Antonio},
	month = apr,
	year = {2004},
	pmid = {15066932},
	keywords = {Acetaminophen, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Case-Control Studies, Cohort Studies, Databases, Factual, Great Britain, Humans, Male, Middle Aged, Prostatic Neoplasms, Risk Factors},
	pages = {649--653}
}

{"_id":"qPhZfSNTitoEdnAzu","bibbaseid":"garcarodrguez-gonzlezprez-inverseassociationbetweennonsteroidalantiinflammatorydrugsandprostatecancer-2004","downloads":0,"creationDate":"2017-08-15T09:38:10.828Z","title":"Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer","author_short":["García Rodríguez, L. A.","González-Pérez, A."],"year":2004,"bibtype":"article","biburl":"http://bibbase.org/zotero/veegee78","bibdata":{"bibtype":"article","type":"article","title":"Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer","volume":"13","issn":"1055-9965","abstract":"BACKGROUND: Prostate cancer is considered a major health problem in western countries. Promising results from observational studies on cancer at other sites fuelled the publication of several studies assessing the association between nonsteroidal anti-inflammatory drug (NSAID) use and prostate cancer. However, these studies show conflicting results. METHODS: We conducted a cohort study with a nested case-control analysis to further study the association between NSAIDs and prostate cancer. We used data from the General Practice Research Database in United Kingdom. RESULTS: Aspirin use was associated with a reduced risk of prostate cancer [odds ratio (OR) = 0.70, 95% confidence interval (95% CI) = 0.61-0.79]. We also found that paracetamol use with a treatment duration longer than 1 year was associated with a decreased risk (OR = 0.65, 95% CI = 0.54-0.78). Non-aspirin-NSAID (NA-NSAID) and paracetamol short-term use was associated with a small increased risk whereas long-term users of NA-NSAIDs presented an OR of 0.89 (95% CI = 0.73-1.08). DISCUSSION: Our findings support a protective effect of aspirin and paracetamol against prostate cancer. The transient elevated risk observed among newly started users of NA-NSAIDs and paracetamol is most likely explained by prothopathic bias. We found some suggestion of a reduced risk with long-term use of NA-NSAID.","language":"eng","number":"4","journal":"Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology","author":[{"propositions":[],"lastnames":["García","Rodríguez"],"firstnames":["Luis","A."],"suffixes":[]},{"propositions":[],"lastnames":["González-Pérez"],"firstnames":["Antonio"],"suffixes":[]}],"month":"April","year":"2004","pmid":"15066932","keywords":"Acetaminophen, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Case-Control Studies, Cohort Studies, Databases, Factual, Great Britain, Humans, Male, Middle Aged, Prostatic Neoplasms, Risk Factors","pages":"649--653","bibtex":"@article{garcia_rodriguez_inverse_2004,\n\ttitle = {Inverse association between nonsteroidal anti-inflammatory drugs and prostate cancer},\n\tvolume = {13},\n\tissn = {1055-9965},\n\tabstract = {BACKGROUND: Prostate cancer is considered a major health problem in western countries. Promising results from observational studies on cancer at other sites fuelled the publication of several studies assessing the association between nonsteroidal anti-inflammatory drug (NSAID) use and prostate cancer. However, these studies show conflicting results.\nMETHODS: We conducted a cohort study with a nested case-control analysis to further study the association between NSAIDs and prostate cancer. We used data from the General Practice Research Database in United Kingdom.\nRESULTS: Aspirin use was associated with a reduced risk of prostate cancer [odds ratio (OR) = 0.70, 95\\% confidence interval (95\\% CI) = 0.61-0.79]. We also found that paracetamol use with a treatment duration longer than 1 year was associated with a decreased risk (OR = 0.65, 95\\% CI = 0.54-0.78). Non-aspirin-NSAID (NA-NSAID) and paracetamol short-term use was associated with a small increased risk whereas long-term users of NA-NSAIDs presented an OR of 0.89 (95\\% CI = 0.73-1.08).\nDISCUSSION: Our findings support a protective effect of aspirin and paracetamol against prostate cancer. The transient elevated risk observed among newly started users of NA-NSAIDs and paracetamol is most likely explained by prothopathic bias. We found some suggestion of a reduced risk with long-term use of NA-NSAID.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Cancer Epidemiology, Biomarkers \\& Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology},\n\tauthor = {García Rodríguez, Luis A. and González-Pérez, Antonio},\n\tmonth = apr,\n\tyear = {2004},\n\tpmid = {15066932},\n\tkeywords = {Acetaminophen, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Case-Control Studies, Cohort Studies, Databases, Factual, Great Britain, Humans, Male, Middle Aged, Prostatic Neoplasms, Risk Factors},\n\tpages = {649--653}\n}\n\n","author_short":["García Rodríguez, L. A.","González-Pérez, A."],"key":"garcia_rodriguez_inverse_2004","id":"garcia_rodriguez_inverse_2004","bibbaseid":"garcarodrguez-gonzlezprez-inverseassociationbetweennonsteroidalantiinflammatorydrugsandprostatecancer-2004","role":"author","urls":{},"keyword":["Acetaminophen","Aged","Anti-Inflammatory Agents","Non-Steroidal","Aspirin","Case-Control Studies","Cohort Studies","Databases","Factual","Great Britain","Humans","Male","Middle Aged","Prostatic Neoplasms","Risk Factors"],"downloads":0},"search_terms":["inverse","association","between","nonsteroidal","anti","inflammatory","drugs","prostate","cancer","garcía rodríguez","gonzález-pérez"],"keywords":["acetaminophen","aged","anti-inflammatory agents","non-steroidal","aspirin","case-control studies","cohort studies","databases","factual","great britain","humans","male","middle aged","prostatic neoplasms","risk factors"],"authorIDs":[],"dataSources":["FmCWXwJibZiWNzpdc"]}